Gender related differential effects of Omega-3E treatment on diabetes-induced left ventricular dysfunction
The present study was designed to determine whether there are beneficial effects of intake of Ω-3E (containing 70% pure omega-3 and 2% natural vitamin E) in cardiac dysfunction of diabetic rats. We also examined whether there are gender-related differences in the responses to the intake of Ω-3E on t...
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| Veröffentlicht in: | Molecular and cellular biochemistry 2007-10, Vol.304 (1-2), p.255-263 |
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| creator | Tuncay, Erkan Seymen, A. Aytac Tanriverdi, Evrim Yaras, Nazmi Tandogan, Berivan Ulusu, N. Nuray Turan, Belma |
| description | The present study was designed to determine whether there are beneficial effects of intake of Ω-3E (containing 70% pure omega-3 and 2% natural vitamin E) in cardiac dysfunction of diabetic rats. We also examined whether there are gender-related differences in the responses to the intake of Ω-3E on the heart dysfunction. Experiments were performed by using Langendorff-perfused hearts from normal, diabetic (with 50 mg/kg streptozotocin), and Ω-3E (50 mg/kg body weight/day) treated diabetic 3-month-old Wistar rats. Ω-3E treatment of the diabetics caused small, but significant decrease (13% and 14% female versus male) in the blood glucose level. Ω-3E treatment of the diabetic female rats did not prevent diabetes-induced decrease in left ventricular developed pressure (LVDP) and increase in left ventricular end-diastolic pressure (LVEDP) with respect to the control female rats. On the other hand, the treatment of diabetic male rats caused significant recovery in depressed LVDP. Furthermore, such treatment of diabetic female and male rats caused significant recovery in depressed rates of changes of developed pressure. This effect was more significant in males. Besides, Ω-3E caused significant further lengthening in the diabetes-induced increased time to the peak of the developed pressure in females, while it normalized the lengthening in the relaxation of the developed pressure in diabetic males. In addition, Ω-3E treatment caused significant restorations in the diabetes-induced altered activities of antioxidant enzymes without any significant gender discrepancy. Present data show that there are gender related differences in diabetic heart dysfunction and the response to antioxidant treatment. |
| doi_str_mv | 10.1007/s11010-007-9508-4 |
| format | Article |
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Aytac ; Tanriverdi, Evrim ; Yaras, Nazmi ; Tandogan, Berivan ; Ulusu, N. Nuray ; Turan, Belma</creator><creatorcontrib>Tuncay, Erkan ; Seymen, A. Aytac ; Tanriverdi, Evrim ; Yaras, Nazmi ; Tandogan, Berivan ; Ulusu, N. Nuray ; Turan, Belma</creatorcontrib><description>The present study was designed to determine whether there are beneficial effects of intake of Ω-3E (containing 70% pure omega-3 and 2% natural vitamin E) in cardiac dysfunction of diabetic rats. We also examined whether there are gender-related differences in the responses to the intake of Ω-3E on the heart dysfunction. Experiments were performed by using Langendorff-perfused hearts from normal, diabetic (with 50 mg/kg streptozotocin), and Ω-3E (50 mg/kg body weight/day) treated diabetic 3-month-old Wistar rats. Ω-3E treatment of the diabetics caused small, but significant decrease (13% and 14% female versus male) in the blood glucose level. Ω-3E treatment of the diabetic female rats did not prevent diabetes-induced decrease in left ventricular developed pressure (LVDP) and increase in left ventricular end-diastolic pressure (LVEDP) with respect to the control female rats. On the other hand, the treatment of diabetic male rats caused significant recovery in depressed LVDP. Furthermore, such treatment of diabetic female and male rats caused significant recovery in depressed rates of changes of developed pressure. This effect was more significant in males. Besides, Ω-3E caused significant further lengthening in the diabetes-induced increased time to the peak of the developed pressure in females, while it normalized the lengthening in the relaxation of the developed pressure in diabetic males. In addition, Ω-3E treatment caused significant restorations in the diabetes-induced altered activities of antioxidant enzymes without any significant gender discrepancy. Present data show that there are gender related differences in diabetic heart dysfunction and the response to antioxidant treatment.</description><identifier>ISSN: 0300-8177</identifier><identifier>EISSN: 1573-4919</identifier><identifier>DOI: 10.1007/s11010-007-9508-4</identifier><identifier>PMID: 17530185</identifier><language>eng</language><publisher>Netherlands: Boston : Springer US</publisher><subject>Animals ; Antioxidants ; Body weight ; Diabetes ; Diabetes Mellitus, Experimental - complications ; Diabetic Angiopathies - drug therapy ; Drug Combinations ; Fatty Acids, Omega-3 - administration & dosage ; Fatty Acids, Omega-3 - pharmacology ; Female ; Females ; Gender ; Heart function ; Heart Ventricles - drug effects ; Male ; Models, Biological ; n-3 Polyunsaturated fatty acids ; Oxidant stress ; Rats ; Rats, Wistar ; Rodents ; Sex Characteristics ; Streptozocin ; Thioredoxin reductase ; Ventricular Dysfunction, Left - drug therapy ; Ventricular Dysfunction, Left - etiology ; Vitamin E - administration & dosage ; Vitamin E - pharmacology</subject><ispartof>Molecular and cellular biochemistry, 2007-10, Vol.304 (1-2), p.255-263</ispartof><rights>Springer Science+Business Media, LLC. 2007</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c350t-a33b97469f3d88d1e868be39cbfd1e0dea2b7db7785192a4a51e2ef14a5f63673</citedby><cites>FETCH-LOGICAL-c350t-a33b97469f3d88d1e868be39cbfd1e0dea2b7db7785192a4a51e2ef14a5f63673</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17530185$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tuncay, Erkan</creatorcontrib><creatorcontrib>Seymen, A. Aytac</creatorcontrib><creatorcontrib>Tanriverdi, Evrim</creatorcontrib><creatorcontrib>Yaras, Nazmi</creatorcontrib><creatorcontrib>Tandogan, Berivan</creatorcontrib><creatorcontrib>Ulusu, N. Nuray</creatorcontrib><creatorcontrib>Turan, Belma</creatorcontrib><title>Gender related differential effects of Omega-3E treatment on diabetes-induced left ventricular dysfunction</title><title>Molecular and cellular biochemistry</title><addtitle>Mol Cell Biochem</addtitle><description>The present study was designed to determine whether there are beneficial effects of intake of Ω-3E (containing 70% pure omega-3 and 2% natural vitamin E) in cardiac dysfunction of diabetic rats. We also examined whether there are gender-related differences in the responses to the intake of Ω-3E on the heart dysfunction. Experiments were performed by using Langendorff-perfused hearts from normal, diabetic (with 50 mg/kg streptozotocin), and Ω-3E (50 mg/kg body weight/day) treated diabetic 3-month-old Wistar rats. Ω-3E treatment of the diabetics caused small, but significant decrease (13% and 14% female versus male) in the blood glucose level. Ω-3E treatment of the diabetic female rats did not prevent diabetes-induced decrease in left ventricular developed pressure (LVDP) and increase in left ventricular end-diastolic pressure (LVEDP) with respect to the control female rats. On the other hand, the treatment of diabetic male rats caused significant recovery in depressed LVDP. Furthermore, such treatment of diabetic female and male rats caused significant recovery in depressed rates of changes of developed pressure. This effect was more significant in males. Besides, Ω-3E caused significant further lengthening in the diabetes-induced increased time to the peak of the developed pressure in females, while it normalized the lengthening in the relaxation of the developed pressure in diabetic males. In addition, Ω-3E treatment caused significant restorations in the diabetes-induced altered activities of antioxidant enzymes without any significant gender discrepancy. Present data show that there are gender related differences in diabetic heart dysfunction and the response to antioxidant treatment.</description><subject>Animals</subject><subject>Antioxidants</subject><subject>Body weight</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Experimental - complications</subject><subject>Diabetic Angiopathies - drug therapy</subject><subject>Drug Combinations</subject><subject>Fatty Acids, Omega-3 - administration & dosage</subject><subject>Fatty Acids, Omega-3 - pharmacology</subject><subject>Female</subject><subject>Females</subject><subject>Gender</subject><subject>Heart function</subject><subject>Heart Ventricles - drug effects</subject><subject>Male</subject><subject>Models, Biological</subject><subject>n-3 Polyunsaturated fatty acids</subject><subject>Oxidant stress</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Rodents</subject><subject>Sex Characteristics</subject><subject>Streptozocin</subject><subject>Thioredoxin reductase</subject><subject>Ventricular Dysfunction, Left - drug therapy</subject><subject>Ventricular Dysfunction, Left - etiology</subject><subject>Vitamin E - administration & dosage</subject><subject>Vitamin E - pharmacology</subject><issn>0300-8177</issn><issn>1573-4919</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpdkUtLJTEQhYOM6NWZH-BGwyzcZSbV6byWgzg6ILhwXId0pyJ96Ycm6QH_vbncCwOu6hT1naKoQ8gF8B_Auf6ZAThwViWzkhvWHpENSC1Ya8F-IRsuOGcGtD4lZzlveYU5wAk5BS0FByM3ZHuHc8BEE46-YKBhiBETzmXwI8Wq-5LpEunjhC-eiVtaEvoyVYAuc6V9hwUzG-aw9tU-Yiz0X52moV9Hn2h4z3Gd-zIs81dyHP2Y8duhnpPn37d_b-7Zw-Pdn5tfD6wXkhfmheisbpWNIhgTAI0yHQrbd7E2PKBvOh06rY0E2_jWS8AGI1QRlVBanJPr_d7XtLytmIubhtzjOPoZlzU7ZRorGmkr-P0TuF3WNNfbnJaqaZWRqkKwh_q05Jwwutc0TD69O-Bul4Lbp-B2cpeCa6vn8rB47SYM_x2Ht1fgag9Evzj_kobsnp8aDjUvw7WSID4A4bCMmg</recordid><startdate>20071001</startdate><enddate>20071001</enddate><creator>Tuncay, Erkan</creator><creator>Seymen, A. 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Aytac</au><au>Tanriverdi, Evrim</au><au>Yaras, Nazmi</au><au>Tandogan, Berivan</au><au>Ulusu, N. Nuray</au><au>Turan, Belma</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gender related differential effects of Omega-3E treatment on diabetes-induced left ventricular dysfunction</atitle><jtitle>Molecular and cellular biochemistry</jtitle><addtitle>Mol Cell Biochem</addtitle><date>2007-10-01</date><risdate>2007</risdate><volume>304</volume><issue>1-2</issue><spage>255</spage><epage>263</epage><pages>255-263</pages><issn>0300-8177</issn><eissn>1573-4919</eissn><abstract>The present study was designed to determine whether there are beneficial effects of intake of Ω-3E (containing 70% pure omega-3 and 2% natural vitamin E) in cardiac dysfunction of diabetic rats. We also examined whether there are gender-related differences in the responses to the intake of Ω-3E on the heart dysfunction. Experiments were performed by using Langendorff-perfused hearts from normal, diabetic (with 50 mg/kg streptozotocin), and Ω-3E (50 mg/kg body weight/day) treated diabetic 3-month-old Wistar rats. Ω-3E treatment of the diabetics caused small, but significant decrease (13% and 14% female versus male) in the blood glucose level. Ω-3E treatment of the diabetic female rats did not prevent diabetes-induced decrease in left ventricular developed pressure (LVDP) and increase in left ventricular end-diastolic pressure (LVEDP) with respect to the control female rats. On the other hand, the treatment of diabetic male rats caused significant recovery in depressed LVDP. Furthermore, such treatment of diabetic female and male rats caused significant recovery in depressed rates of changes of developed pressure. This effect was more significant in males. Besides, Ω-3E caused significant further lengthening in the diabetes-induced increased time to the peak of the developed pressure in females, while it normalized the lengthening in the relaxation of the developed pressure in diabetic males. In addition, Ω-3E treatment caused significant restorations in the diabetes-induced altered activities of antioxidant enzymes without any significant gender discrepancy. Present data show that there are gender related differences in diabetic heart dysfunction and the response to antioxidant treatment.</abstract><cop>Netherlands</cop><pub>Boston : Springer US</pub><pmid>17530185</pmid><doi>10.1007/s11010-007-9508-4</doi><tpages>9</tpages></addata></record> |
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| subjects | Animals Antioxidants Body weight Diabetes Diabetes Mellitus, Experimental - complications Diabetic Angiopathies - drug therapy Drug Combinations Fatty Acids, Omega-3 - administration & dosage Fatty Acids, Omega-3 - pharmacology Female Females Gender Heart function Heart Ventricles - drug effects Male Models, Biological n-3 Polyunsaturated fatty acids Oxidant stress Rats Rats, Wistar Rodents Sex Characteristics Streptozocin Thioredoxin reductase Ventricular Dysfunction, Left - drug therapy Ventricular Dysfunction, Left - etiology Vitamin E - administration & dosage Vitamin E - pharmacology |
| title | Gender related differential effects of Omega-3E treatment on diabetes-induced left ventricular dysfunction |
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