ATP-binding-cassette transporters in hematopoietic stem cells and their utility as therapeutical targets in acute and chronic myeloid leukemia
ATP-binding-cassette (ABC) transporters are evolutionary extremely well-conserved transmembrane proteins that are highly expressed in hematopoietic stem cells (HSCs). The physiological function in human stem cells is believed to be protection against genetic damage caused by both environmental and n...
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| Veröffentlicht in: | Leukemia 2007-10, Vol.21 (10), p.2094-2102 |
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| description | ATP-binding-cassette (ABC) transporters are evolutionary extremely well-conserved transmembrane proteins that are highly expressed in hematopoietic stem cells (HSCs). The physiological function in human stem cells is believed to be protection against genetic damage caused by both environmental and naturally occurring xenobiotics. Additionally, ABC transporters have been implicated in the maintenance of quiescence and cell fate decisions of stem cells. These physiological roles suggest a potential role in the pathogenesis and biology of stem cell-derived hematological malignancies such as acute and chronic myeloid leukemia. This paper reviews the (patho)physiological role of ABC transporters in human normal and malignant HSCs and discusses its implications for their utility as therapeutical targets to eradicate leukemic stem cells in these diseases. |
| doi_str_mv | 10.1038/sj.leu.2404859 |
| format | Article |
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The physiological function in human stem cells is believed to be protection against genetic damage caused by both environmental and naturally occurring xenobiotics. Additionally, ABC transporters have been implicated in the maintenance of quiescence and cell fate decisions of stem cells. These physiological roles suggest a potential role in the pathogenesis and biology of stem cell-derived hematological malignancies such as acute and chronic myeloid leukemia. 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Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Medical sciences ; Medicine ; Medicine & Public Health ; Membrane proteins ; Mice ; Models, Biological ; Myeloid leukemia ; Oncology ; Pathogenesis ; Phenotype ; Physiology ; Piperazines - pharmacology ; Protein Binding ; Proteins ; Pyrimidines - pharmacology ; review ; Stem cells ; Xenobiotics</subject><ispartof>Leukemia, 2007-10, Vol.21 (10), p.2094-2102</ispartof><rights>Springer Nature Limited 2007</rights><rights>2007 INIST-CNRS</rights><rights>COPYRIGHT 2007 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Oct 2007</rights><rights>Nature Publishing Group 2007.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c508t-cba6159dd745002d036be1abbfde794723209f1dfcbb0f18b9a527c89119d2a73</citedby><cites>FETCH-LOGICAL-c508t-cba6159dd745002d036be1abbfde794723209f1dfcbb0f18b9a527c89119d2a73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/sj.leu.2404859$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/sj.leu.2404859$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19133240$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17657220$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Raaijmakers, M H G P</creatorcontrib><title>ATP-binding-cassette transporters in hematopoietic stem cells and their utility as therapeutical targets in acute and chronic myeloid leukemia</title><title>Leukemia</title><addtitle>Leukemia</addtitle><addtitle>Leukemia</addtitle><description>ATP-binding-cassette (ABC) transporters are evolutionary extremely well-conserved transmembrane proteins that are highly expressed in hematopoietic stem cells (HSCs). The physiological function in human stem cells is believed to be protection against genetic damage caused by both environmental and naturally occurring xenobiotics. Additionally, ABC transporters have been implicated in the maintenance of quiescence and cell fate decisions of stem cells. These physiological roles suggest a potential role in the pathogenesis and biology of stem cell-derived hematological malignancies such as acute and chronic myeloid leukemia. This paper reviews the (patho)physiological role of ABC transporters in human normal and malignant HSCs and discusses its implications for their utility as therapeutical targets to eradicate leukemic stem cells in these diseases.</description><subject>ABC transporters</subject><subject>Adenosine Triphosphate - metabolism</subject><subject>Animals</subject><subject>ATP-Binding Cassette Transporters - metabolism</subject><subject>ATP-Binding Cassette Transporters - physiology</subject><subject>ATP-Binding Cassette Transporters - therapeutic use</subject><subject>Benzamides</subject><subject>Binding</subject><subject>Biological and medical sciences</subject><subject>Biology</subject><subject>Bone marrow</subject><subject>Cancer</subject><subject>Cancer Research</subject><subject>Cell Differentiation</subject><subject>Cell fate</subject><subject>Chromosome aberrations</subject><subject>Chronic myeloid leukemia</subject><subject>Control</subject><subject>Critical Care Medicine</subject><subject>Cytotoxicity</subject><subject>Drug Resistance, Neoplasm</subject><subject>Dyes</subject><subject>Gene expression</subject><subject>Gene Expression Regulation, Leukemic</subject><subject>Genetic aspects</subject><subject>Genotype & phenotype</subject><subject>Health aspects</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Hematology</subject><subject>Hematopoietic stem cells</subject><subject>Hematopoietic Stem Cells - cytology</subject><subject>Hematopoietic Stem Cells - metabolism</subject><subject>Humans</subject><subject>Imatinib Mesylate</subject><subject>Intensive</subject><subject>Internal Medicine</subject><subject>Leukemia</subject><subject>Leukemia, Myelogenous, Chronic, BCR-ABL Positive - metabolism</subject><subject>Leukemia, Myeloid, Acute - metabolism</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Membrane proteins</subject><subject>Mice</subject><subject>Models, Biological</subject><subject>Myeloid leukemia</subject><subject>Oncology</subject><subject>Pathogenesis</subject><subject>Phenotype</subject><subject>Physiology</subject><subject>Piperazines - pharmacology</subject><subject>Protein Binding</subject><subject>Proteins</subject><subject>Pyrimidines - pharmacology</subject><subject>review</subject><subject>Stem cells</subject><subject>Xenobiotics</subject><issn>0887-6924</issn><issn>1476-5551</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkk2P0zAQhiMEYsvClSOyQHBL13bi2DlWK76kleCwnC3HmbQuiV08zqF_gt-Ms61UgbTiYFnyPPPOvJ4piteMrhmt1A3u1yPMa17TWon2SbFitWxKIQR7WqyoUrJsWl5fFS8Q95QuweZ5ccVkIyTndFX83tx_Lzvne-e3pTWIkBKQFI3HQ4gJIhLnyQ4mk8IhOEjOEkwwEQvjiMT4nqQduEjm5EaXjsTg8hDNAfKLNSNJJm4hPcgYO2fxJcfuYvBZajrCGFxPsoefMDnzsng2mBHh1fm-Ln58-nh_-6W8-_b56-3mrrSCqlTazjRMtH0va0Ep72nVdMBM1w09yLaWvOK0HVg_2K6jA1NdawSXVrWMtT03srouPpx0DzH8mgGTnhwuloyHMKNuFG8Xjf-CnNKqYpJm8N0_4D7M0WcTmje1kKziqs7U20cpTkU-jbpIbc0I2vkh5HnYpa7eMKUUrSinl84eqB2YMe0wjPnXg8e_wfUJtDEgRhj0IbrJxKNmVC9LpHGv8wD0eYlywptzk3M3QX_Bz1uTgfdnwGAe8ZC3xTq8cC2rqiyWuZsThznktxAvbh8p_QcKot-1</recordid><startdate>20071001</startdate><enddate>20071001</enddate><creator>Raaijmakers, M H G P</creator><general>Nature Publishing Group UK</general><general>Nature Publishing</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7RV</scope><scope>7T5</scope><scope>7T7</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7QO</scope><scope>7X8</scope></search><sort><creationdate>20071001</creationdate><title>ATP-binding-cassette transporters in hematopoietic stem cells and their utility as therapeutical targets in acute and chronic myeloid leukemia</title><author>Raaijmakers, M H G P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c508t-cba6159dd745002d036be1abbfde794723209f1dfcbb0f18b9a527c89119d2a73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>ABC transporters</topic><topic>Adenosine Triphosphate - metabolism</topic><topic>Animals</topic><topic>ATP-Binding Cassette Transporters - metabolism</topic><topic>ATP-Binding Cassette Transporters - physiology</topic><topic>ATP-Binding Cassette Transporters - therapeutic use</topic><topic>Benzamides</topic><topic>Binding</topic><topic>Biological and medical sciences</topic><topic>Biology</topic><topic>Bone marrow</topic><topic>Cancer</topic><topic>Cancer Research</topic><topic>Cell Differentiation</topic><topic>Cell fate</topic><topic>Chromosome aberrations</topic><topic>Chronic myeloid leukemia</topic><topic>Control</topic><topic>Critical Care Medicine</topic><topic>Cytotoxicity</topic><topic>Drug Resistance, Neoplasm</topic><topic>Dyes</topic><topic>Gene expression</topic><topic>Gene Expression Regulation, Leukemic</topic><topic>Genetic aspects</topic><topic>Genotype & phenotype</topic><topic>Health aspects</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Hematology</topic><topic>Hematopoietic stem cells</topic><topic>Hematopoietic Stem Cells - cytology</topic><topic>Hematopoietic Stem Cells - metabolism</topic><topic>Humans</topic><topic>Imatinib Mesylate</topic><topic>Intensive</topic><topic>Internal Medicine</topic><topic>Leukemia</topic><topic>Leukemia, Myelogenous, Chronic, BCR-ABL Positive - metabolism</topic><topic>Leukemia, Myeloid, Acute - metabolism</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Membrane proteins</topic><topic>Mice</topic><topic>Models, Biological</topic><topic>Myeloid leukemia</topic><topic>Oncology</topic><topic>Pathogenesis</topic><topic>Phenotype</topic><topic>Physiology</topic><topic>Piperazines - pharmacology</topic><topic>Protein Binding</topic><topic>Proteins</topic><topic>Pyrimidines - pharmacology</topic><topic>review</topic><topic>Stem cells</topic><topic>Xenobiotics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Raaijmakers, M H G P</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Biotechnology Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Leukemia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Raaijmakers, M H G P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>ATP-binding-cassette transporters in hematopoietic stem cells and their utility as therapeutical targets in acute and chronic myeloid leukemia</atitle><jtitle>Leukemia</jtitle><stitle>Leukemia</stitle><addtitle>Leukemia</addtitle><date>2007-10-01</date><risdate>2007</risdate><volume>21</volume><issue>10</issue><spage>2094</spage><epage>2102</epage><pages>2094-2102</pages><issn>0887-6924</issn><eissn>1476-5551</eissn><coden>LEUKED</coden><abstract>ATP-binding-cassette (ABC) transporters are evolutionary extremely well-conserved transmembrane proteins that are highly expressed in hematopoietic stem cells (HSCs). The physiological function in human stem cells is believed to be protection against genetic damage caused by both environmental and naturally occurring xenobiotics. Additionally, ABC transporters have been implicated in the maintenance of quiescence and cell fate decisions of stem cells. These physiological roles suggest a potential role in the pathogenesis and biology of stem cell-derived hematological malignancies such as acute and chronic myeloid leukemia. This paper reviews the (patho)physiological role of ABC transporters in human normal and malignant HSCs and discusses its implications for their utility as therapeutical targets to eradicate leukemic stem cells in these diseases.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>17657220</pmid><doi>10.1038/sj.leu.2404859</doi><tpages>9</tpages></addata></record> |
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| subjects | ABC transporters Adenosine Triphosphate - metabolism Animals ATP-Binding Cassette Transporters - metabolism ATP-Binding Cassette Transporters - physiology ATP-Binding Cassette Transporters - therapeutic use Benzamides Binding Biological and medical sciences Biology Bone marrow Cancer Cancer Research Cell Differentiation Cell fate Chromosome aberrations Chronic myeloid leukemia Control Critical Care Medicine Cytotoxicity Drug Resistance, Neoplasm Dyes Gene expression Gene Expression Regulation, Leukemic Genetic aspects Genotype & phenotype Health aspects Hematologic and hematopoietic diseases Hematology Hematopoietic stem cells Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - metabolism Humans Imatinib Mesylate Intensive Internal Medicine Leukemia Leukemia, Myelogenous, Chronic, BCR-ABL Positive - metabolism Leukemia, Myeloid, Acute - metabolism Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical sciences Medicine Medicine & Public Health Membrane proteins Mice Models, Biological Myeloid leukemia Oncology Pathogenesis Phenotype Physiology Piperazines - pharmacology Protein Binding Proteins Pyrimidines - pharmacology review Stem cells Xenobiotics |
| title | ATP-binding-cassette transporters in hematopoietic stem cells and their utility as therapeutical targets in acute and chronic myeloid leukemia |
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