Pathway for Differentiation of Human Embryonic Stem Cells to Vascular Cell Components and Their Potential for Vascular Regeneration

OBJECTIVE—We demonstrated previously that mouse embryonic stem (ES) cell–derived vascular endothelial growth factor receptor-2 (VEGF-R2)–positive cells can differentiate into both vascular endothelial cells and mural cells. This time, we investigated kinetics of differentiation of human ES cells to...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2007-10, Vol.27 (10), p.2127-2134
Hauptverfasser:	Sone, Masakatsu, Itoh, Hiroshi, Yamahara, Kenichi, Yamashita, Jun K, Yurugi-Kobayashi, Takami, Nonoguchi, Akane, Suzuki, Yutaka, Chao, Ting-Hsing, Sawada, Naoki, Fukunaga, Yasutomo, Miyashita, Kazutoshi, Park, Kwijun, Oyamada, Naofumi, Sawada, Naoya, Taura, Daisuke, Tamura, Naohisa, Kondo, Yasushi, Nito, Shinji, Suemori, Hirofumi, Nakatsuji, Norio, Nishikawa, Shin-Ichi, Nakao, Kazuwa
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - metabolism Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Angiogenic Proteins - metabolism Animals Antigens, CD - metabolism Antigens, Neoplasm - metabolism Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Blood vessels and receptors Cadherins - metabolism Cardiology. Vascular system Cell Differentiation Cell Line Cell Proliferation Cell Transformation, Neoplastic - metabolism Disease Models, Animal Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Embryonic Stem Cells - immunology Embryonic Stem Cells - metabolism Emergency and intensive care: renal failure. Dialysis management Endothelial Cells - immunology Endothelial Cells - metabolism Endothelial Cells - transplantation Fundamental and applied biological sciences. Psychology Hindlimb - blood supply Humans Intensive care medicine Ischemia - metabolism Ischemia - physiopathology Ischemia - surgery Kinetics Medical sciences Mice Mice, Inbred C57BL Mice, Nude Myocytes, Smooth Muscle - immunology Myocytes, Smooth Muscle - metabolism Myocytes, Smooth Muscle - transplantation Neovascularization, Physiologic Receptor, Platelet-Derived Growth Factor alpha - metabolism Receptor, Platelet-Derived Growth Factor beta - metabolism Regeneration Regional Blood Flow Stem Cell Transplantation Vascular Endothelial Growth Factor Receptor-2 - metabolism Vertebrates: cardiovascular system
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