Ixocarpalactone A isolated from the Mexican tomatillo shows potent antiproliferative and apoptotic activity in colon cancer cells

Physalis philadelphica Lam, commonly known as a tomatillo, is a staple of the Mesoamerican cuisine. In our laboratory, an ethyl acetate‐soluble extract and four withanolides [ixocarpalactone A (IxoA), ixocarpalactone B, philadelphicalactone B, and withaphysacarpin] were isolated. Studies conducted o...

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Veröffentlicht in:	The FEBS journal 2006-12, Vol.273 (24), p.5714-5723
Hauptverfasser:	Choi, Juliana K., Murillo, Genoveva, Su, Bao‐Ning, Pezzuto, John M., Kinghorn, A. D., Mehta, Rajendra G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Apoptosis Apoptosis - drug effects Biochemistry Cell Cycle - drug effects Cell Line, Tumor Chemotherapy colon cancer Colonic Neoplasms - drug therapy Colonic Neoplasms - metabolism Colorectal cancer Down-Regulation - drug effects Drug Screening Assays, Antitumor E2F1 Transcription Factor - metabolism Ergosterol - analogs & derivatives Ergosterol - chemistry Ergosterol - therapeutic use Humans ixocarpalactone A Mexico Pharmacology Physalis - chemistry Physalis philadelphica Phytotherapy Proteins Retinoblastoma Protein - metabolism tomatillo Transcription Factor DP1 - metabolism Up-Regulation - drug effects Vegetables
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