The effects of 10% hypertonic saline, 0.9% saline and hydroxy ethyl starch infusions on hydro-electrolyte status and adrenal function in healthy conscious dogs
The purpose of this study was to investigate the influence of different saline and colloid solutions on adrenal steroid secretion in dogs. Six healthy male Beagles underwent three infusion cycles: 10 min infusion of 30 ml/kg of NaCl 0.9%, 5 ml/kg of hydroxy ethyl starch, or 5 ml/kg of NaCl 10%. Plas...
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| Veröffentlicht in: | Research in veterinary science 2007-12, Vol.83 (3), p.322-330 |
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| creator | Goy-Thollot, Isabelle Garnier, François Bonnet, Jeanne-Marie |
| description | The purpose of this study was to investigate the influence of different saline and colloid solutions on adrenal steroid secretion in dogs. Six healthy male Beagles underwent three infusion cycles: 10
min infusion of 30
ml/kg of NaCl 0.9%, 5
ml/kg of hydroxy ethyl starch, or 5
ml/kg of NaCl 10%. Plasma osmolality, hematocrit, total solids, cortisol and aldosterone levels were measured at 0, 5, 15, 30, 60, 120, 180 and 240
min after beginning infusion. Plasma ACTH levels were measured at 0, 15 and 240
min. An identical timing of sampling was applied during a control session omitting the fluid infusion. Osmolality, sodium, chloride and cortisol levels were found to be significantly higher with hypertonic saline solute compared to control. All fluid infusions lead to lowered plasma potassium, hematocrit, total solids and aldosterone values. ACTH concentrations did not show significant changes with any of the infusion cycles. The increase in cortisol levels suggests that hypertonic saline infusion could be interesting in critical care resuscitation, particularly in patients who are suffering from relative adrenal insufficiency. |
| doi_str_mv | 10.1016/j.rvsc.2007.01.004 |
| format | Article |
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min infusion of 30
ml/kg of NaCl 0.9%, 5
ml/kg of hydroxy ethyl starch, or 5
ml/kg of NaCl 10%. Plasma osmolality, hematocrit, total solids, cortisol and aldosterone levels were measured at 0, 5, 15, 30, 60, 120, 180 and 240
min after beginning infusion. Plasma ACTH levels were measured at 0, 15 and 240
min. An identical timing of sampling was applied during a control session omitting the fluid infusion. Osmolality, sodium, chloride and cortisol levels were found to be significantly higher with hypertonic saline solute compared to control. All fluid infusions lead to lowered plasma potassium, hematocrit, total solids and aldosterone values. ACTH concentrations did not show significant changes with any of the infusion cycles. The increase in cortisol levels suggests that hypertonic saline infusion could be interesting in critical care resuscitation, particularly in patients who are suffering from relative adrenal insufficiency.</description><identifier>ISSN: 0034-5288</identifier><identifier>EISSN: 1532-2661</identifier><identifier>DOI: 10.1016/j.rvsc.2007.01.004</identifier><identifier>PMID: 17343887</identifier><language>eng</language><publisher>England: Elsevier India Pvt Ltd</publisher><subject>adrenal cortex hormones ; Adrenal glands ; Adrenal Glands - drug effects ; Adrenal Glands - metabolism ; Adrenal Glands - physiology ; Adrenal steroids ; Adrenocorticotropic Hormone - secretion ; aldosterone ; Aldosterone - secretion ; animal models ; Animals ; aqueous solutions ; blood chemistry ; Cattle ; Consciousness ; corticotropin ; cortisol ; Dog ; dogs ; Dogs - physiology ; Dose-Response Relationship, Drug ; Electrolytes ; Fluid infusion ; Health ; Hematocrit ; hormone secretion ; Hormones ; hydrocolloids ; Hydrocortisone - secretion ; hydroxy ethyl starch ; Hydroxyethyl Starch Derivatives - administration & dosage ; Hydroxyethyl Starch Derivatives - pharmacology ; intravenous injection ; Male ; normal values ; Osmolality ; Osmolar Concentration ; osmolarity ; physiological response ; Pituitary gland ; sodium chloride ; Sodium Chloride - administration & dosage ; Sodium Chloride - pharmacology ; Stress ; therapeutics ; Time Factors ; total solids ; Veterinary medicine ; Water-Electrolyte Balance - drug effects</subject><ispartof>Research in veterinary science, 2007-12, Vol.83 (3), p.322-330</ispartof><rights>2007 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c406t-d3236ef94bffcee47db7eb38ece15d8e561a0bd0da27f174df5dd68f958a07013</citedby><cites>FETCH-LOGICAL-c406t-d3236ef94bffcee47db7eb38ece15d8e561a0bd0da27f174df5dd68f958a07013</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.rvsc.2007.01.004$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17343887$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Goy-Thollot, Isabelle</creatorcontrib><creatorcontrib>Garnier, François</creatorcontrib><creatorcontrib>Bonnet, Jeanne-Marie</creatorcontrib><title>The effects of 10% hypertonic saline, 0.9% saline and hydroxy ethyl starch infusions on hydro-electrolyte status and adrenal function in healthy conscious dogs</title><title>Research in veterinary science</title><addtitle>Res Vet Sci</addtitle><description>The purpose of this study was to investigate the influence of different saline and colloid solutions on adrenal steroid secretion in dogs. Six healthy male Beagles underwent three infusion cycles: 10
min infusion of 30
ml/kg of NaCl 0.9%, 5
ml/kg of hydroxy ethyl starch, or 5
ml/kg of NaCl 10%. Plasma osmolality, hematocrit, total solids, cortisol and aldosterone levels were measured at 0, 5, 15, 30, 60, 120, 180 and 240
min after beginning infusion. Plasma ACTH levels were measured at 0, 15 and 240
min. An identical timing of sampling was applied during a control session omitting the fluid infusion. Osmolality, sodium, chloride and cortisol levels were found to be significantly higher with hypertonic saline solute compared to control. All fluid infusions lead to lowered plasma potassium, hematocrit, total solids and aldosterone values. ACTH concentrations did not show significant changes with any of the infusion cycles. The increase in cortisol levels suggests that hypertonic saline infusion could be interesting in critical care resuscitation, particularly in patients who are suffering from relative adrenal insufficiency.</description><subject>adrenal cortex hormones</subject><subject>Adrenal glands</subject><subject>Adrenal Glands - drug effects</subject><subject>Adrenal Glands - metabolism</subject><subject>Adrenal Glands - physiology</subject><subject>Adrenal steroids</subject><subject>Adrenocorticotropic Hormone - secretion</subject><subject>aldosterone</subject><subject>Aldosterone - secretion</subject><subject>animal models</subject><subject>Animals</subject><subject>aqueous solutions</subject><subject>blood chemistry</subject><subject>Cattle</subject><subject>Consciousness</subject><subject>corticotropin</subject><subject>cortisol</subject><subject>Dog</subject><subject>dogs</subject><subject>Dogs - physiology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Electrolytes</subject><subject>Fluid infusion</subject><subject>Health</subject><subject>Hematocrit</subject><subject>hormone secretion</subject><subject>Hormones</subject><subject>hydrocolloids</subject><subject>Hydrocortisone - secretion</subject><subject>hydroxy ethyl starch</subject><subject>Hydroxyethyl Starch Derivatives - administration & dosage</subject><subject>Hydroxyethyl Starch Derivatives - pharmacology</subject><subject>intravenous injection</subject><subject>Male</subject><subject>normal values</subject><subject>Osmolality</subject><subject>Osmolar Concentration</subject><subject>osmolarity</subject><subject>physiological response</subject><subject>Pituitary gland</subject><subject>sodium chloride</subject><subject>Sodium Chloride - administration & dosage</subject><subject>Sodium Chloride - pharmacology</subject><subject>Stress</subject><subject>therapeutics</subject><subject>Time Factors</subject><subject>total solids</subject><subject>Veterinary medicine</subject><subject>Water-Electrolyte Balance - drug effects</subject><issn>0034-5288</issn><issn>1532-2661</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kV2L1DAUhoso7uzqH_BCA7Je2XqSfqSFvZFl_YAFL9y9DmlyspOh04xJu9hf41_1jB0QvBACIfC8DyfnzbJXHAoOvPmwK-JjMoUAkAXwAqB6km14XYpcNA1_mm0AyiqvRdueZecp7YAIzuXz7IzLsirbVm6yX3dbZOgcmimx4BiHS7ZdDhinMHrDkh78iO8ZFN3l6cH0aAmxMfxcGE7bZWBp0tFsmR_dnHwYSTSuRI4DiWMYlgmP1DSnP3FtI456YG4ezUQJirIt6oFszJDA-ECkDQ_pRfbM6SHhy9N9kd1_urm7_pLffvv89frjbW4qaKbclqJs0HVV75xBrKTtJfZliwZ5bVusG66ht2C1kI7Lyrra2qZ1Xd1qkMDLi-zd6j3E8GPGNKm9TwaHQY9Is6imFR2IriHw7T_gLsyRPpMUh7KmUwlJlFgpE0NKEZ06RL_XcSFIHctTO3UsTx3LU8AVVUOh1yf13O_R_o2c2iLgzQo4HZR-iD6p---CpgdoeQ2yI-JqJZB29egxKtoljgatj9SEssH_b4LffCy28g</recordid><startdate>20071201</startdate><enddate>20071201</enddate><creator>Goy-Thollot, Isabelle</creator><creator>Garnier, François</creator><creator>Bonnet, Jeanne-Marie</creator><general>Elsevier India Pvt Ltd</general><general>Elsevier Limited</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20071201</creationdate><title>The effects of 10% hypertonic saline, 0.9% saline and hydroxy ethyl starch infusions on hydro-electrolyte status and adrenal function in healthy conscious dogs</title><author>Goy-Thollot, Isabelle ; Garnier, François ; Bonnet, Jeanne-Marie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c406t-d3236ef94bffcee47db7eb38ece15d8e561a0bd0da27f174df5dd68f958a07013</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>adrenal cortex hormones</topic><topic>Adrenal glands</topic><topic>Adrenal Glands - drug effects</topic><topic>Adrenal Glands - metabolism</topic><topic>Adrenal Glands - physiology</topic><topic>Adrenal steroids</topic><topic>Adrenocorticotropic Hormone - secretion</topic><topic>aldosterone</topic><topic>Aldosterone - secretion</topic><topic>animal models</topic><topic>Animals</topic><topic>aqueous solutions</topic><topic>blood chemistry</topic><topic>Cattle</topic><topic>Consciousness</topic><topic>corticotropin</topic><topic>cortisol</topic><topic>Dog</topic><topic>dogs</topic><topic>Dogs - physiology</topic><topic>Dose-Response Relationship, Drug</topic><topic>Electrolytes</topic><topic>Fluid infusion</topic><topic>Health</topic><topic>Hematocrit</topic><topic>hormone secretion</topic><topic>Hormones</topic><topic>hydrocolloids</topic><topic>Hydrocortisone - secretion</topic><topic>hydroxy ethyl starch</topic><topic>Hydroxyethyl Starch Derivatives - administration & dosage</topic><topic>Hydroxyethyl Starch Derivatives - pharmacology</topic><topic>intravenous injection</topic><topic>Male</topic><topic>normal values</topic><topic>Osmolality</topic><topic>Osmolar Concentration</topic><topic>osmolarity</topic><topic>physiological response</topic><topic>Pituitary gland</topic><topic>sodium chloride</topic><topic>Sodium Chloride - administration & dosage</topic><topic>Sodium Chloride - pharmacology</topic><topic>Stress</topic><topic>therapeutics</topic><topic>Time Factors</topic><topic>total solids</topic><topic>Veterinary medicine</topic><topic>Water-Electrolyte Balance - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Goy-Thollot, Isabelle</creatorcontrib><creatorcontrib>Garnier, François</creatorcontrib><creatorcontrib>Bonnet, Jeanne-Marie</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Research in veterinary science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Goy-Thollot, Isabelle</au><au>Garnier, François</au><au>Bonnet, Jeanne-Marie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effects of 10% hypertonic saline, 0.9% saline and hydroxy ethyl starch infusions on hydro-electrolyte status and adrenal function in healthy conscious dogs</atitle><jtitle>Research in veterinary science</jtitle><addtitle>Res Vet Sci</addtitle><date>2007-12-01</date><risdate>2007</risdate><volume>83</volume><issue>3</issue><spage>322</spage><epage>330</epage><pages>322-330</pages><issn>0034-5288</issn><eissn>1532-2661</eissn><abstract>The purpose of this study was to investigate the influence of different saline and colloid solutions on adrenal steroid secretion in dogs. Six healthy male Beagles underwent three infusion cycles: 10
min infusion of 30
ml/kg of NaCl 0.9%, 5
ml/kg of hydroxy ethyl starch, or 5
ml/kg of NaCl 10%. Plasma osmolality, hematocrit, total solids, cortisol and aldosterone levels were measured at 0, 5, 15, 30, 60, 120, 180 and 240
min after beginning infusion. Plasma ACTH levels were measured at 0, 15 and 240
min. An identical timing of sampling was applied during a control session omitting the fluid infusion. Osmolality, sodium, chloride and cortisol levels were found to be significantly higher with hypertonic saline solute compared to control. All fluid infusions lead to lowered plasma potassium, hematocrit, total solids and aldosterone values. ACTH concentrations did not show significant changes with any of the infusion cycles. The increase in cortisol levels suggests that hypertonic saline infusion could be interesting in critical care resuscitation, particularly in patients who are suffering from relative adrenal insufficiency.</abstract><cop>England</cop><pub>Elsevier India Pvt Ltd</pub><pmid>17343887</pmid><doi>10.1016/j.rvsc.2007.01.004</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0034-5288 |
| ispartof | Research in veterinary science, 2007-12, Vol.83 (3), p.322-330 |
| issn | 0034-5288 1532-2661 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | adrenal cortex hormones Adrenal glands Adrenal Glands - drug effects Adrenal Glands - metabolism Adrenal Glands - physiology Adrenal steroids Adrenocorticotropic Hormone - secretion aldosterone Aldosterone - secretion animal models Animals aqueous solutions blood chemistry Cattle Consciousness corticotropin cortisol Dog dogs Dogs - physiology Dose-Response Relationship, Drug Electrolytes Fluid infusion Health Hematocrit hormone secretion Hormones hydrocolloids Hydrocortisone - secretion hydroxy ethyl starch Hydroxyethyl Starch Derivatives - administration & dosage Hydroxyethyl Starch Derivatives - pharmacology intravenous injection Male normal values Osmolality Osmolar Concentration osmolarity physiological response Pituitary gland sodium chloride Sodium Chloride - administration & dosage Sodium Chloride - pharmacology Stress therapeutics Time Factors total solids Veterinary medicine Water-Electrolyte Balance - drug effects |
| title | The effects of 10% hypertonic saline, 0.9% saline and hydroxy ethyl starch infusions on hydro-electrolyte status and adrenal function in healthy conscious dogs |
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