The NF-kappaB/IL-6 pathway in metastatic androgen-independent prostate cancer: new therapeutic approaches?

The nuclear factor of kappa beta (NF-kappaB) transcription factor regulates the transcription of numerous genes including that of interleukin 6 (IL-6). The IL-6 acts as an autocrine and paracrine growth factor of androgen-independent prostate cancer. An aberrant expression of the IL-6 gene and an in...

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Veröffentlicht in:	World journal of urology 2007-10, Vol.25 (5), p.477-489
Hauptverfasser:	Paule, Bernard, Terry, Stéphane, Kheuang, Laurence, Soyeux, Pascale, Vacherot, Francis, de la Taille, Alexandre
Format:	Artikel
Sprache:	eng
Schlagworte:	Bone Neoplasms - drug therapy Bone Neoplasms - physiopathology Bone Neoplasms - secondary Cell Communication - drug effects Cell Communication - physiology Gene Expression Regulation, Neoplastic - drug effects Humans Interleukin-6 - metabolism Male Neoplasm Metastasis - drug therapy Neoplasm Metastasis - physiopathology NF-kappa B - drug effects NF-kappa B - metabolism Osteoblasts - drug effects Osteoblasts - pathology Prostatic Neoplasms - drug therapy Prostatic Neoplasms - metabolism Prostatic Neoplasms - physiopathology
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