Quality of life after islet transplant : Impact of the number of islet infusions and metabolic outcome
The health-related quality of life (HRQL; Health Utilities Index Mark 2) and the fear of hypoglycemia (Hypoglycemia Fear Survey) were assessed after islet transplant; the impact of a single islet infusion and of the metabolic outcome were determined. A control group included 166 patients with type 1...
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Veröffentlicht in: | Transplantation 2007-09, Vol.84 (5), p.664-666 |
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container_title | Transplantation |
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creator | TOSO, Christian JAMES SHAPIRO, A. M BOWKER, Samantha DINYARI, Parastoo PATY, Breay RYAN, Edmond A SENIOR, Peter JOHNSON, Jeffrey A |
description | The health-related quality of life (HRQL; Health Utilities Index Mark 2) and the fear of hypoglycemia (Hypoglycemia Fear Survey) were assessed after islet transplant; the impact of a single islet infusion and of the metabolic outcome were determined. A control group included 166 patients with type 1 diabetes. Islet transplant had no impact on overall HRQL. Prior to transplant, islet recipients had more fear of hypoglycemia than controls (P |
doi_str_mv | 10.1097/01.tp.0000280550.01028.89 |
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M ; BOWKER, Samantha ; DINYARI, Parastoo ; PATY, Breay ; RYAN, Edmond A ; SENIOR, Peter ; JOHNSON, Jeffrey A</creator><creatorcontrib>TOSO, Christian ; JAMES SHAPIRO, A. M ; BOWKER, Samantha ; DINYARI, Parastoo ; PATY, Breay ; RYAN, Edmond A ; SENIOR, Peter ; JOHNSON, Jeffrey A</creatorcontrib><description>The health-related quality of life (HRQL; Health Utilities Index Mark 2) and the fear of hypoglycemia (Hypoglycemia Fear Survey) were assessed after islet transplant; the impact of a single islet infusion and of the metabolic outcome were determined. A control group included 166 patients with type 1 diabetes. Islet transplant had no impact on overall HRQL. Prior to transplant, islet recipients had more fear of hypoglycemia than controls (P<0.000001), but this improved up to 36 months after transplant (P<0.00001, pretransplant vs. each time point). With a single islet infusion, this fear improved substantially (P<0.00001), but improved further with subsequent islet infusions (P</=0.01). Fear of hypoglycemia correlated with the occurrence of hypoglycemia (r=0.47, P=0.01), and even more so with blood glucose stability (r=0.56, P=0.0007) and insulin requirement (r=0.69, P=0.000002).</description><identifier>ISSN: 0041-1337</identifier><identifier>EISSN: 1534-6080</identifier><identifier>DOI: 10.1097/01.tp.0000280550.01028.89</identifier><identifier>PMID: 17876283</identifier><identifier>CODEN: TRPLAU</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott</publisher><subject>Adult ; Biological and medical sciences ; Female ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Humans ; Hyperglycemia - blood ; Islets of Langerhans - metabolism ; Islets of Langerhans Transplantation ; Male ; Medical sciences ; Quality of Life ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surveys and Questionnaires ; Tissue, organ and graft immunology ; Treatment Outcome</subject><ispartof>Transplantation, 2007-09, Vol.84 (5), p.664-666</ispartof><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c493t-7fab98d2bcdbe90e7bc8649c05e742b4683620aa182e27adaaab94741233ea523</citedby><cites>FETCH-LOGICAL-c493t-7fab98d2bcdbe90e7bc8649c05e742b4683620aa182e27adaaab94741233ea523</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27925,27926</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19085432$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17876283$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>TOSO, Christian</creatorcontrib><creatorcontrib>JAMES SHAPIRO, A. M</creatorcontrib><creatorcontrib>BOWKER, Samantha</creatorcontrib><creatorcontrib>DINYARI, Parastoo</creatorcontrib><creatorcontrib>PATY, Breay</creatorcontrib><creatorcontrib>RYAN, Edmond A</creatorcontrib><creatorcontrib>SENIOR, Peter</creatorcontrib><creatorcontrib>JOHNSON, Jeffrey A</creatorcontrib><title>Quality of life after islet transplant : Impact of the number of islet infusions and metabolic outcome</title><title>Transplantation</title><addtitle>Transplantation</addtitle><description>The health-related quality of life (HRQL; Health Utilities Index Mark 2) and the fear of hypoglycemia (Hypoglycemia Fear Survey) were assessed after islet transplant; the impact of a single islet infusion and of the metabolic outcome were determined. A control group included 166 patients with type 1 diabetes. Islet transplant had no impact on overall HRQL. Prior to transplant, islet recipients had more fear of hypoglycemia than controls (P<0.000001), but this improved up to 36 months after transplant (P<0.00001, pretransplant vs. each time point). With a single islet infusion, this fear improved substantially (P<0.00001), but improved further with subsequent islet infusions (P</=0.01). Fear of hypoglycemia correlated with the occurrence of hypoglycemia (r=0.47, P=0.01), and even more so with blood glucose stability (r=0.56, P=0.0007) and insulin requirement (r=0.69, P=0.000002).</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Humans</subject><subject>Hyperglycemia - blood</subject><subject>Islets of Langerhans - metabolism</subject><subject>Islets of Langerhans Transplantation</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Quality of Life</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. 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M ; BOWKER, Samantha ; DINYARI, Parastoo ; PATY, Breay ; RYAN, Edmond A ; SENIOR, Peter ; JOHNSON, Jeffrey A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c493t-7fab98d2bcdbe90e7bc8649c05e742b4683620aa182e27adaaab94741233ea523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Humans</topic><topic>Hyperglycemia - blood</topic><topic>Islets of Langerhans - metabolism</topic><topic>Islets of Langerhans Transplantation</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Quality of Life</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. 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M</au><au>BOWKER, Samantha</au><au>DINYARI, Parastoo</au><au>PATY, Breay</au><au>RYAN, Edmond A</au><au>SENIOR, Peter</au><au>JOHNSON, Jeffrey A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Quality of life after islet transplant : Impact of the number of islet infusions and metabolic outcome</atitle><jtitle>Transplantation</jtitle><addtitle>Transplantation</addtitle><date>2007-09-15</date><risdate>2007</risdate><volume>84</volume><issue>5</issue><spage>664</spage><epage>666</epage><pages>664-666</pages><issn>0041-1337</issn><eissn>1534-6080</eissn><coden>TRPLAU</coden><abstract>The health-related quality of life (HRQL; Health Utilities Index Mark 2) and the fear of hypoglycemia (Hypoglycemia Fear Survey) were assessed after islet transplant; the impact of a single islet infusion and of the metabolic outcome were determined. A control group included 166 patients with type 1 diabetes. Islet transplant had no impact on overall HRQL. Prior to transplant, islet recipients had more fear of hypoglycemia than controls (P<0.000001), but this improved up to 36 months after transplant (P<0.00001, pretransplant vs. each time point). With a single islet infusion, this fear improved substantially (P<0.00001), but improved further with subsequent islet infusions (P</=0.01). Fear of hypoglycemia correlated with the occurrence of hypoglycemia (r=0.47, P=0.01), and even more so with blood glucose stability (r=0.56, P=0.0007) and insulin requirement (r=0.69, P=0.000002).</abstract><cop>Hagerstown, MD</cop><pub>Lippincott</pub><pmid>17876283</pmid><doi>10.1097/01.tp.0000280550.01028.89</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Adult Biological and medical sciences Female Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Hyperglycemia - blood Islets of Langerhans - metabolism Islets of Langerhans Transplantation Male Medical sciences Quality of Life Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surveys and Questionnaires Tissue, organ and graft immunology Treatment Outcome |
title | Quality of life after islet transplant : Impact of the number of islet infusions and metabolic outcome |
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