Evaluation of Human CYP1A2 and CYP3A4 mRNA Expression in Hepatocytes from Chimeric Mice with Humanized Liver

We investigated and compared the expression of human CYPs mRNA in primary cultures of cryopreserved human hepatocytes and in chimeric mice constructed by transplanting hepatocytes from the same human donors. Analysis was performed by real-time reverse-transcription polymerase chain reaction. Initial...

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Veröffentlicht in:	Drug metabolism and pharmacokinetics 2006, Vol.21 (6), p.465-474
Hauptverfasser:	Yoshitsugu, Hiroki, Nishimura, Masuhiro, Tateno, Chise, Kataoka, Miho, Takahashi, Eiji, Soeno, Yoshinori, Yoshizato, Katsutoshi, Yokoi, Tsuyoshi, Naito, Shinsaku
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals beta-Naphthoflavone - pharmacology Cell Transplantation Cells, Cultured chimeric mouse liver CYP1A2 CYP3A4 Cytochrome P-450 CYP1A2 - genetics Cytochrome P-450 CYP3A Cytochrome P-450 Enzyme System - genetics Female Gene Expression - drug effects Hepatocytes - drug effects Hepatocytes - enzymology Hepatocytes - transplantation human hepatocytes Humans induction Male Mice Mice, SCID real-time RT-PCR Reverse Transcriptase Polymerase Chain Reaction Rifampin - pharmacology RNA, Messenger - genetics RNA, Messenger - metabolism Time Factors Transplantation Chimera - genetics Transplantation, Heterologous
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