Urinary biomarkers of IgA nephropathy and other IgA-associated renal diseases
IgA nephropathy is the most common primary glomerulonephritis and is a frequent cause for chronic kidney disease in children and young adults. Glomerular deposition of IgA also characterizes other renal disorders, including Henoch-Schoenlein purpura nephritis and immune-complex glomerulonephritis af...
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Veröffentlicht in: | World journal of urology 2007-10, Vol.25 (5), p.467-476 |
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description | IgA nephropathy is the most common primary glomerulonephritis and is a frequent cause for chronic kidney disease in children and young adults. Glomerular deposition of IgA also characterizes other renal disorders, including Henoch-Schoenlein purpura nephritis and immune-complex glomerulonephritis afflicting patients with liver disease due to chronic infection with the hepatitis C virus. Several treatment options are often considered, with the goal to prevent end-stage renal failure. Unfortunately, the diagnosis currently requires an invasive procedure, a renal biopsy. Because of the inherent risks, repetitive renal biopsy is frequently foregone as a means to monitor the clinical course or response to treatment. Recent advances in the analysis of the urinary proteome suggest that the excreted polypeptides include disease-specific patterns. We review recent studies of the various techniques for the identification and validation of such urinary biomarkers of IgA-associated glomerulonephritides. Currently, capillary electrophoresis coupled with mass spectrometry (MS) offers the greatest promise. To date, it seems more likely that disease-specific urinary polypeptide biomarkers are comprised of a panel of several distinct and well-defined peptides rather than a single molecule. Even most patients in clinical remission with normal clinical testing (dipstick urinalysis and quantitative proteinuria) were correctly classified by the pattern of polypeptides identified by capillary electrophoresis coupled with MS. With confirmation and refinement, such urinary testing may provide a tool for the diagnosis and monitoring of patients with IgA-associated renal diseases that is more sensitive than current standard clinical testing and far less risky than renal biopsy. |
doi_str_mv | 10.1007/s00345-007-0192-5 |
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Glomerular deposition of IgA also characterizes other renal disorders, including Henoch-Schoenlein purpura nephritis and immune-complex glomerulonephritis afflicting patients with liver disease due to chronic infection with the hepatitis C virus. Several treatment options are often considered, with the goal to prevent end-stage renal failure. Unfortunately, the diagnosis currently requires an invasive procedure, a renal biopsy. Because of the inherent risks, repetitive renal biopsy is frequently foregone as a means to monitor the clinical course or response to treatment. Recent advances in the analysis of the urinary proteome suggest that the excreted polypeptides include disease-specific patterns. We review recent studies of the various techniques for the identification and validation of such urinary biomarkers of IgA-associated glomerulonephritides. Currently, capillary electrophoresis coupled with mass spectrometry (MS) offers the greatest promise. To date, it seems more likely that disease-specific urinary polypeptide biomarkers are comprised of a panel of several distinct and well-defined peptides rather than a single molecule. Even most patients in clinical remission with normal clinical testing (dipstick urinalysis and quantitative proteinuria) were correctly classified by the pattern of polypeptides identified by capillary electrophoresis coupled with MS. With confirmation and refinement, such urinary testing may provide a tool for the diagnosis and monitoring of patients with IgA-associated renal diseases that is more sensitive than current standard clinical testing and far less risky than renal biopsy.</description><identifier>ISSN: 0724-4983</identifier><identifier>EISSN: 1433-8726</identifier><identifier>DOI: 10.1007/s00345-007-0192-5</identifier><identifier>PMID: 17619884</identifier><identifier>CODEN: WJURDJ</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Biological and medical sciences ; Biomarkers ; Biomarkers - urine ; Biopsy ; Capillary electrophoresis ; Chronic infection ; Diagnosis ; Down-Regulation ; Electrophoresis, Capillary - methods ; End-stage renal disease ; Glomerulonephritis ; Glomerulonephritis, IGA - diagnosis ; Glomerulonephritis, IGA - physiopathology ; Glomerulonephritis, IGA - urine ; Hepatitis C ; Humans ; IgA nephropathy ; Immunoglobulin A ; Kidney diseases ; Liver diseases ; Mass Spectrometry - methods ; Mass spectroscopy ; Medical sciences ; Nephritis ; Nephrology. Urinary tract diseases ; Nephropathies. Renovascular diseases. Renal failure ; Patients ; Polypeptides ; Proteinuria ; Proteomes ; Proteomics - methods ; Purpura ; Purpura, Schoenlein-Henoch - complications ; Purpura, Schoenlein-Henoch - physiopathology ; Remission ; Renal failure ; Up-Regulation ; Urinalysis ; Young adults</subject><ispartof>World journal of urology, 2007-10, Vol.25 (5), p.467-476</ispartof><rights>2007 INIST-CNRS</rights><rights>Springer-Verlag 2007</rights><rights>Springer-Verlag 2007.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c450t-c4bb153f642760b13f7f72d08ace7978fda5aee2f0315606749f8e4d45773a4f3</citedby><cites>FETCH-LOGICAL-c450t-c4bb153f642760b13f7f72d08ace7978fda5aee2f0315606749f8e4d45773a4f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19142548$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17619884$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>JULIAN, Bruce A</creatorcontrib><creatorcontrib>WITTKE, Stefan</creatorcontrib><creatorcontrib>HAUBITZ, Marion</creatorcontrib><creatorcontrib>ZURBIG, Petra</creatorcontrib><creatorcontrib>SCHIFFER, Eric</creatorcontrib><creatorcontrib>MCGUIRE, Brendan M</creatorcontrib><creatorcontrib>WYATT, Robert J</creatorcontrib><creatorcontrib>NOVAK, Jan</creatorcontrib><title>Urinary biomarkers of IgA nephropathy and other IgA-associated renal diseases</title><title>World journal of urology</title><addtitle>World J Urol</addtitle><description>IgA nephropathy is the most common primary glomerulonephritis and is a frequent cause for chronic kidney disease in children and young adults. Glomerular deposition of IgA also characterizes other renal disorders, including Henoch-Schoenlein purpura nephritis and immune-complex glomerulonephritis afflicting patients with liver disease due to chronic infection with the hepatitis C virus. Several treatment options are often considered, with the goal to prevent end-stage renal failure. Unfortunately, the diagnosis currently requires an invasive procedure, a renal biopsy. Because of the inherent risks, repetitive renal biopsy is frequently foregone as a means to monitor the clinical course or response to treatment. Recent advances in the analysis of the urinary proteome suggest that the excreted polypeptides include disease-specific patterns. We review recent studies of the various techniques for the identification and validation of such urinary biomarkers of IgA-associated glomerulonephritides. Currently, capillary electrophoresis coupled with mass spectrometry (MS) offers the greatest promise. To date, it seems more likely that disease-specific urinary polypeptide biomarkers are comprised of a panel of several distinct and well-defined peptides rather than a single molecule. Even most patients in clinical remission with normal clinical testing (dipstick urinalysis and quantitative proteinuria) were correctly classified by the pattern of polypeptides identified by capillary electrophoresis coupled with MS. With confirmation and refinement, such urinary testing may provide a tool for the diagnosis and monitoring of patients with IgA-associated renal diseases that is more sensitive than current standard clinical testing and far less risky than renal biopsy.</description><subject>Biological and medical sciences</subject><subject>Biomarkers</subject><subject>Biomarkers - urine</subject><subject>Biopsy</subject><subject>Capillary electrophoresis</subject><subject>Chronic infection</subject><subject>Diagnosis</subject><subject>Down-Regulation</subject><subject>Electrophoresis, Capillary - methods</subject><subject>End-stage renal disease</subject><subject>Glomerulonephritis</subject><subject>Glomerulonephritis, IGA - diagnosis</subject><subject>Glomerulonephritis, IGA - physiopathology</subject><subject>Glomerulonephritis, IGA - urine</subject><subject>Hepatitis C</subject><subject>Humans</subject><subject>IgA nephropathy</subject><subject>Immunoglobulin A</subject><subject>Kidney diseases</subject><subject>Liver diseases</subject><subject>Mass Spectrometry - methods</subject><subject>Mass spectroscopy</subject><subject>Medical sciences</subject><subject>Nephritis</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Nephropathies. Renovascular diseases. Renal failure</subject><subject>Patients</subject><subject>Polypeptides</subject><subject>Proteinuria</subject><subject>Proteomes</subject><subject>Proteomics - methods</subject><subject>Purpura</subject><subject>Purpura, Schoenlein-Henoch - complications</subject><subject>Purpura, Schoenlein-Henoch - physiopathology</subject><subject>Remission</subject><subject>Renal failure</subject><subject>Up-Regulation</subject><subject>Urinalysis</subject><subject>Young adults</subject><issn>0724-4983</issn><issn>1433-8726</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kU1r3DAQhkVpaTYfPyCXYlqSm9vRlyUdQ8gXpPTSnMXYlrJOvdZG4z3sv6-WXQgEcpkZmGeGl_dl7JzDTw5gfhGAVLouYw3ciVp_YguupKytEc1ntgAjVK2clUfsmOgFgJsG9Fd2VDp31qoF-_2UhwnztmqHtML8L2SqUqwenq-qKayXOa1xXm4rnPoqzcuQd5saiVI34Bz6KocJx6ofKCAFOmVfIo4Uzg79hD3d3vy9vq8f_9w9XF891p3SMJfatlzL2ChRBLVcRhON6MFiF4wzNvaoMQQRQXLdQGOUizaoXmljJKooT9jl_u86p9dNoNmvBurCOOIU0oZ8Y4U1jjcF_PEOfEmbXCSTF41TRoM2rlDfP6QECCeKhALxPdTlRJRD9Os8FMu2noPfxeH3cfjduIvD63Lz7fB4065C_3Zx8L8AFwcAqcMxZpy6gd44x5XQysr_xw6QUQ</recordid><startdate>20071001</startdate><enddate>20071001</enddate><creator>JULIAN, Bruce A</creator><creator>WITTKE, Stefan</creator><creator>HAUBITZ, Marion</creator><creator>ZURBIG, Petra</creator><creator>SCHIFFER, Eric</creator><creator>MCGUIRE, Brendan M</creator><creator>WYATT, Robert J</creator><creator>NOVAK, Jan</creator><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20071001</creationdate><title>Urinary biomarkers of IgA nephropathy and other IgA-associated renal diseases</title><author>JULIAN, Bruce A ; WITTKE, Stefan ; HAUBITZ, Marion ; ZURBIG, Petra ; SCHIFFER, Eric ; MCGUIRE, Brendan M ; WYATT, Robert J ; NOVAK, Jan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c450t-c4bb153f642760b13f7f72d08ace7978fda5aee2f0315606749f8e4d45773a4f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Biological and medical sciences</topic><topic>Biomarkers</topic><topic>Biomarkers - urine</topic><topic>Biopsy</topic><topic>Capillary electrophoresis</topic><topic>Chronic infection</topic><topic>Diagnosis</topic><topic>Down-Regulation</topic><topic>Electrophoresis, Capillary - methods</topic><topic>End-stage renal disease</topic><topic>Glomerulonephritis</topic><topic>Glomerulonephritis, IGA - diagnosis</topic><topic>Glomerulonephritis, IGA - physiopathology</topic><topic>Glomerulonephritis, IGA - urine</topic><topic>Hepatitis C</topic><topic>Humans</topic><topic>IgA nephropathy</topic><topic>Immunoglobulin A</topic><topic>Kidney diseases</topic><topic>Liver diseases</topic><topic>Mass Spectrometry - methods</topic><topic>Mass spectroscopy</topic><topic>Medical sciences</topic><topic>Nephritis</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Nephropathies. Renovascular diseases. Renal failure</topic><topic>Patients</topic><topic>Polypeptides</topic><topic>Proteinuria</topic><topic>Proteomes</topic><topic>Proteomics - methods</topic><topic>Purpura</topic><topic>Purpura, Schoenlein-Henoch - complications</topic><topic>Purpura, Schoenlein-Henoch - physiopathology</topic><topic>Remission</topic><topic>Renal failure</topic><topic>Up-Regulation</topic><topic>Urinalysis</topic><topic>Young adults</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>JULIAN, Bruce A</creatorcontrib><creatorcontrib>WITTKE, Stefan</creatorcontrib><creatorcontrib>HAUBITZ, Marion</creatorcontrib><creatorcontrib>ZURBIG, Petra</creatorcontrib><creatorcontrib>SCHIFFER, Eric</creatorcontrib><creatorcontrib>MCGUIRE, Brendan M</creatorcontrib><creatorcontrib>WYATT, Robert J</creatorcontrib><creatorcontrib>NOVAK, Jan</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>World journal of urology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>JULIAN, Bruce A</au><au>WITTKE, Stefan</au><au>HAUBITZ, Marion</au><au>ZURBIG, Petra</au><au>SCHIFFER, Eric</au><au>MCGUIRE, Brendan M</au><au>WYATT, Robert J</au><au>NOVAK, Jan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Urinary biomarkers of IgA nephropathy and other IgA-associated renal diseases</atitle><jtitle>World journal of urology</jtitle><addtitle>World J Urol</addtitle><date>2007-10-01</date><risdate>2007</risdate><volume>25</volume><issue>5</issue><spage>467</spage><epage>476</epage><pages>467-476</pages><issn>0724-4983</issn><eissn>1433-8726</eissn><coden>WJURDJ</coden><abstract>IgA nephropathy is the most common primary glomerulonephritis and is a frequent cause for chronic kidney disease in children and young adults. Glomerular deposition of IgA also characterizes other renal disorders, including Henoch-Schoenlein purpura nephritis and immune-complex glomerulonephritis afflicting patients with liver disease due to chronic infection with the hepatitis C virus. Several treatment options are often considered, with the goal to prevent end-stage renal failure. Unfortunately, the diagnosis currently requires an invasive procedure, a renal biopsy. Because of the inherent risks, repetitive renal biopsy is frequently foregone as a means to monitor the clinical course or response to treatment. Recent advances in the analysis of the urinary proteome suggest that the excreted polypeptides include disease-specific patterns. We review recent studies of the various techniques for the identification and validation of such urinary biomarkers of IgA-associated glomerulonephritides. Currently, capillary electrophoresis coupled with mass spectrometry (MS) offers the greatest promise. To date, it seems more likely that disease-specific urinary polypeptide biomarkers are comprised of a panel of several distinct and well-defined peptides rather than a single molecule. Even most patients in clinical remission with normal clinical testing (dipstick urinalysis and quantitative proteinuria) were correctly classified by the pattern of polypeptides identified by capillary electrophoresis coupled with MS. With confirmation and refinement, such urinary testing may provide a tool for the diagnosis and monitoring of patients with IgA-associated renal diseases that is more sensitive than current standard clinical testing and far less risky than renal biopsy.</abstract><cop>Heidelberg</cop><cop>Berlin</cop><cop>New York, NY</cop><pub>Springer</pub><pmid>17619884</pmid><doi>10.1007/s00345-007-0192-5</doi><tpages>10</tpages></addata></record> |
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subjects | Biological and medical sciences Biomarkers Biomarkers - urine Biopsy Capillary electrophoresis Chronic infection Diagnosis Down-Regulation Electrophoresis, Capillary - methods End-stage renal disease Glomerulonephritis Glomerulonephritis, IGA - diagnosis Glomerulonephritis, IGA - physiopathology Glomerulonephritis, IGA - urine Hepatitis C Humans IgA nephropathy Immunoglobulin A Kidney diseases Liver diseases Mass Spectrometry - methods Mass spectroscopy Medical sciences Nephritis Nephrology. Urinary tract diseases Nephropathies. Renovascular diseases. Renal failure Patients Polypeptides Proteinuria Proteomes Proteomics - methods Purpura Purpura, Schoenlein-Henoch - complications Purpura, Schoenlein-Henoch - physiopathology Remission Renal failure Up-Regulation Urinalysis Young adults |
title | Urinary biomarkers of IgA nephropathy and other IgA-associated renal diseases |
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