Human Effector Memory CD4+ T Cells Directly Recognize Allogeneic Endothelial Cells In Vitro and In Vivo

The frequency of circulating alloreactive human memory T cells correlates with allograft rejection. Memory T cells may be divided into effector memory (T(EM)) and central memory (T(CM)) cell subsets, but their specific roles in allograft rejection are unknown. We report that CD4+ T(EM) (CD45RO+ CCR7...

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Veröffentlicht in:	The Journal of immunology (1950) 2007-10, Vol.179 (7), p.4397-4404
Hauptverfasser:	Shiao, Stephen L, Kirkiles-Smith, Nancy C, Shepherd, Benjamin R, McNiff, Jennifer M, Carr, Edward J, Pober, Jordan S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigen-Presenting Cells - immunology B7-1 Antigen - immunology CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism CD58 Antigens - immunology Cells, Cultured Endothelial Cells - immunology Female Humans Immunologic Memory - immunology Interferon-gamma - biosynthesis Interleukin-2 - biosynthesis Mice Mice, SCID
Online-Zugang:	Volltext
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