Intra-operative parathyroid identification using methylene blue in parathyroid surgery
The objective of this study was to determine the value of intra-operative methylene blue (MB) during parathyroid surgery. We did a retrospective study of 473 patients after initial exploration for previously untreated symptomatic primary hyperparathyroidism. Procedural and post procedural data were...
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| Veröffentlicht in: | The American surgeon 2007-08, Vol.73 (8), p.820-823 |
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| creator | HAN, Nancy BUMPOUS, Jeffrey M GOLDSTEIN, Richard E FLEMING, Muffin M FLYNN, Michael B |
| description | The objective of this study was to determine the value of intra-operative methylene blue (MB) during parathyroid surgery. We did a retrospective study of 473 patients after initial exploration for previously untreated symptomatic primary hyperparathyroidism. Procedural and post procedural data were collected on four groups of patients: minimally invasive parathyroidectomy with MB (n = 147), and without MB (n = 205), bilateral parathyroid exploration with intra-operative parathormone assay with MB (n = 56), and without MB (n = 65). Length of surgery was shorter for patients explored with MB (P = 0.026). For the minimally invasive parathyroidectomy group, the difference between the MB and non-MB groups was seven minutes. Twelve minutes was the difference between the MB and non-MB intra-operative parathormone assay groups. Length of stay, local complications, and correction of hypercalcemia after parathyroidectomy were not significantly affected by the use of MB. Systemic complications were lower in the MB groups. Aside from a statistically significant, but quantitatively minimal decrease in the length of surgery, no consistent benefit was identified with the use of MB for intra-operative parathyroid identification. |
| doi_str_mv | 10.1177/000313480707300819 |
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We did a retrospective study of 473 patients after initial exploration for previously untreated symptomatic primary hyperparathyroidism. Procedural and post procedural data were collected on four groups of patients: minimally invasive parathyroidectomy with MB (n = 147), and without MB (n = 205), bilateral parathyroid exploration with intra-operative parathormone assay with MB (n = 56), and without MB (n = 65). Length of surgery was shorter for patients explored with MB (P = 0.026). For the minimally invasive parathyroidectomy group, the difference between the MB and non-MB groups was seven minutes. Twelve minutes was the difference between the MB and non-MB intra-operative parathormone assay groups. Length of stay, local complications, and correction of hypercalcemia after parathyroidectomy were not significantly affected by the use of MB. Systemic complications were lower in the MB groups. Aside from a statistically significant, but quantitatively minimal decrease in the length of surgery, no consistent benefit was identified with the use of MB for intra-operative parathyroid identification.</description><identifier>ISSN: 0003-1348</identifier><identifier>EISSN: 1555-9823</identifier><identifier>DOI: 10.1177/000313480707300819</identifier><identifier>PMID: 17879694</identifier><identifier>CODEN: AMSUAW</identifier><language>eng</language><publisher>Atlanta, GA: Southeastern Surgical Congress</publisher><subject>Biological and medical sciences ; Enzyme Inhibitors - administration & dosage ; Follow-Up Studies ; General aspects ; Hospitals ; Humans ; Hyperparathyroidism, Primary - pathology ; Hyperparathyroidism, Primary - surgery ; Infusions, Intravenous ; Intraoperative Care - methods ; Length of Stay ; Medical sciences ; Methylene Blue - administration & dosage ; Minimally Invasive Surgical Procedures ; Parathyroid Glands - pathology ; Parathyroid Glands - surgery ; Parathyroidectomy - methods ; Reproducibility of Results ; Retrospective Studies ; Risk ; Staining and Labeling - methods ; Surgery ; Thyroid gland ; Treatment Outcome ; Variables</subject><ispartof>The American surgeon, 2007-08, Vol.73 (8), p.820-823</ispartof><rights>2007 INIST-CNRS</rights><rights>Copyright Southeastern Surgical Congress Aug 2007</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c402t-7e3fdd18c7b7077a2e5956d967f1ea816c5a97e87e8681a7725fc26d8269bba63</citedby><cites>FETCH-LOGICAL-c402t-7e3fdd18c7b7077a2e5956d967f1ea816c5a97e87e8681a7725fc26d8269bba63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>309,310,314,780,784,789,790,23929,23930,25139,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19050750$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17879694$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HAN, Nancy</creatorcontrib><creatorcontrib>BUMPOUS, Jeffrey M</creatorcontrib><creatorcontrib>GOLDSTEIN, Richard E</creatorcontrib><creatorcontrib>FLEMING, Muffin M</creatorcontrib><creatorcontrib>FLYNN, Michael B</creatorcontrib><title>Intra-operative parathyroid identification using methylene blue in parathyroid surgery</title><title>The American surgeon</title><addtitle>Am Surg</addtitle><description>The objective of this study was to determine the value of intra-operative methylene blue (MB) during parathyroid surgery. We did a retrospective study of 473 patients after initial exploration for previously untreated symptomatic primary hyperparathyroidism. Procedural and post procedural data were collected on four groups of patients: minimally invasive parathyroidectomy with MB (n = 147), and without MB (n = 205), bilateral parathyroid exploration with intra-operative parathormone assay with MB (n = 56), and without MB (n = 65). Length of surgery was shorter for patients explored with MB (P = 0.026). For the minimally invasive parathyroidectomy group, the difference between the MB and non-MB groups was seven minutes. Twelve minutes was the difference between the MB and non-MB intra-operative parathormone assay groups. Length of stay, local complications, and correction of hypercalcemia after parathyroidectomy were not significantly affected by the use of MB. Systemic complications were lower in the MB groups. Aside from a statistically significant, but quantitatively minimal decrease in the length of surgery, no consistent benefit was identified with the use of MB for intra-operative parathyroid identification.</description><subject>Biological and medical sciences</subject><subject>Enzyme Inhibitors - administration & dosage</subject><subject>Follow-Up Studies</subject><subject>General aspects</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Hyperparathyroidism, Primary - pathology</subject><subject>Hyperparathyroidism, Primary - surgery</subject><subject>Infusions, Intravenous</subject><subject>Intraoperative Care - methods</subject><subject>Length of Stay</subject><subject>Medical sciences</subject><subject>Methylene Blue - administration & dosage</subject><subject>Minimally Invasive Surgical Procedures</subject><subject>Parathyroid Glands - pathology</subject><subject>Parathyroid Glands - surgery</subject><subject>Parathyroidectomy - methods</subject><subject>Reproducibility of Results</subject><subject>Retrospective Studies</subject><subject>Risk</subject><subject>Staining and Labeling - 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Academic</collection><jtitle>The American surgeon</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HAN, Nancy</au><au>BUMPOUS, Jeffrey M</au><au>GOLDSTEIN, Richard E</au><au>FLEMING, Muffin M</au><au>FLYNN, Michael B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intra-operative parathyroid identification using methylene blue in parathyroid surgery</atitle><jtitle>The American surgeon</jtitle><addtitle>Am Surg</addtitle><date>2007-08-01</date><risdate>2007</risdate><volume>73</volume><issue>8</issue><spage>820</spage><epage>823</epage><pages>820-823</pages><issn>0003-1348</issn><eissn>1555-9823</eissn><coden>AMSUAW</coden><abstract>The objective of this study was to determine the value of intra-operative methylene blue (MB) during parathyroid surgery. We did a retrospective study of 473 patients after initial exploration for previously untreated symptomatic primary hyperparathyroidism. Procedural and post procedural data were collected on four groups of patients: minimally invasive parathyroidectomy with MB (n = 147), and without MB (n = 205), bilateral parathyroid exploration with intra-operative parathormone assay with MB (n = 56), and without MB (n = 65). Length of surgery was shorter for patients explored with MB (P = 0.026). For the minimally invasive parathyroidectomy group, the difference between the MB and non-MB groups was seven minutes. Twelve minutes was the difference between the MB and non-MB intra-operative parathormone assay groups. Length of stay, local complications, and correction of hypercalcemia after parathyroidectomy were not significantly affected by the use of MB. Systemic complications were lower in the MB groups. Aside from a statistically significant, but quantitatively minimal decrease in the length of surgery, no consistent benefit was identified with the use of MB for intra-operative parathyroid identification.</abstract><cop>Atlanta, GA</cop><pub>Southeastern Surgical Congress</pub><pmid>17879694</pmid><doi>10.1177/000313480707300819</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The American surgeon, 2007-08, Vol.73 (8), p.820-823 |
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| subjects | Biological and medical sciences Enzyme Inhibitors - administration & dosage Follow-Up Studies General aspects Hospitals Humans Hyperparathyroidism, Primary - pathology Hyperparathyroidism, Primary - surgery Infusions, Intravenous Intraoperative Care - methods Length of Stay Medical sciences Methylene Blue - administration & dosage Minimally Invasive Surgical Procedures Parathyroid Glands - pathology Parathyroid Glands - surgery Parathyroidectomy - methods Reproducibility of Results Retrospective Studies Risk Staining and Labeling - methods Surgery Thyroid gland Treatment Outcome Variables |
| title | Intra-operative parathyroid identification using methylene blue in parathyroid surgery |
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