Characterization of follistatin-related gene as a negative regulatory factor for activin family members during mouse heart development

Follistatin-related gene (FLRG) encodes a secretory glycoprotein that has characteristic cysteine-rich follistatin domains. FLRG protein binds to and neutralizes several transforming growth factor-β (TGF-β) superfamily members, including myostatin (MSTN), which is a potent negative regulator of skel...

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Veröffentlicht in:	The Journal of Medical Investigation 2007, Vol.54(3,4), pp.276-288
Hauptverfasser:	Takehara-Kasamatsu, Yuka, Tsuchida, Kunihiro, Nakatani, Masashi, Murakami, Tatsuya, Kurisaki, Akira, Hashimoto, Osamu, Ohuchi, Hideyo, Kurose, Hitomi, Mori, Kazuhiro, Kagami, Shoji, Noji, Sumihare, Sugino, Hiromu
Format:	Artikel
Sprache:	eng
Schlagworte:	activin Activins - metabolism Animals Base Sequence Cell Line DNA Primers - genetics Female Fetal Heart - embryology Fetal Heart - metabolism FLRG follistatin Follistatin-Related Proteins Gene Expression Regulation, Developmental heart Immunohistochemistry In Situ Hybridization Mice Mice, Inbred ICR Myostatin Pregnancy Proteins - genetics Proteins - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Signal Transduction Transforming Growth Factor beta - genetics Transforming Growth Factor beta - metabolism
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