Increased competition for antigen during priming negatively impacts the generation of memory CD4 T cells

The factors involved in the differentiation of memory CD4 T cells from naïve precursors are poorly understood. We developed a system to examine the effect of increased competition for antigen by CD4 T cells on the generation of memory in response to infection with a recombinant vesicular stomatitis...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2007-09, Vol.104 (38), p.15045-15050
Hauptverfasser:	Blair, David A, Lefrançois, Leo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive transfer Animals Antibodies, Monoclonal - immunology Antibodies, Monoclonal - metabolism Antigens Antigens - immunology Biological Sciences CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism Cell Division Cytokines Developmental biology Flow Cytometry Immunologic Memory Immunology Infections Lymphocyte activation Lymphocyte Activation - immunology Memory Mice Mice, Inbred C57BL Mice, Transgenic Spleen T cell antigen receptors T cell receptors T lymphocytes T lymphoid precursor cells Vesicular stomatitis virus
Online-Zugang:	Volltext
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