In vitro degradation of hexanitrohexaazaisowurtzitane (CL-20) by cytosolic enzymes of Japanese quail and the rabbit

Hexanitrohexaazaisowurtzitane (CL‐20) is a polycyclic nitramine explosive and propellant, currently being considered as a potential replacement for existing cyclic nitramine explosives. Earlier studies have provided evidence suggestive of adverse liver effects in adult Coturnix spp. exposed to CL‐20...

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Veröffentlicht in:	Environmental toxicology and chemistry 2006-12, Vol.25 (12), p.3221-3229
Hauptverfasser:	Bardai, Ghalib K., Halasz, Annamaria, Sunahara, Geoffrey I., Dodard, Sabine, Spear, Philip A., Grosse, Stephan, Hoang, Johnston, Hawari, Jalal
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animal, plant and microbial ecology Animals Applied ecology Aza Compounds - chemistry Aza Compounds - metabolism Aza Compounds - pharmacology Biodegradation Biological and medical sciences Biotransformation Carbon - metabolism Chemicals Coturnix - metabolism Coturnix japonica Cytosol - drug effects Cytosol - enzymology Ecotoxicology, biological effects of pollution Embryo Embryos Enzyme Inhibitors - pharmacology Enzymes Explosives Fundamental and applied biological sciences. Psychology General aspects Glutathione Transferase - antagonists & inhibitors Glutathione Transferase - chemistry Glutathione Transferase - isolation & purification Glutathione Transferase - metabolism Glutathione-S-transferase Heterocyclic Compounds - chemistry Heterocyclic Compounds - metabolism Heterocyclic Compounds - pharmacology Japanese quail Liquid chromatography Liver Liver - drug effects Liver - enzymology Mammalia Mass spectrometry Metabolites Molecular Conformation Molecular Sequence Data Molecular structure Plasma Proteins Rabbits Time Factors Tissue analysis Vertebrates: general zoology, morphology, phylogeny, systematics, cytogenetics, geographical distribution
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