Reactive oxygen species, DNA damage, and error-prone repair : A model for genomic instability with progression in myeloid leukemia?

Myelodysplastic syndromes (MDS) comprise a heterogeneous group of disorders characterized by ineffective hematopoiesis, with an increased propensity to develop acute myelogenous leukemia (AML). The molecular basis for MDS progression is unknown, but a key element in MDS disease progression is loss o...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2007-09, Vol.67 (18), p.8762-8771
Hauptverfasser:	RASSOOL, Feyruz V, GAYMES, Terry J, MULTI, Ghulam J, PADUA, Rose Ann, OMIDVAR, Nader, BRADY, Nicola, BEURLET, Stephanie, PLA, Marika, REBOUL, Murielle, LEA, Nicholas, CHOMIENNE, Christine, THOMAS, Nicholas S. B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Biological and medical sciences Disease Models, Animal Disease Progression DNA Damage DNA Repair Genes, bcl-2 Genes, ras Genomic Instability Hematologic and hematopoietic diseases Leukemia, Myeloid - genetics Leukemia, Myeloid - metabolism Leukemia, Myeloid - pathology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical sciences Mice Mice, Transgenic Pharmacology. Drug treatments Reactive Oxygen Species - metabolism Tumors
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