In non-neoplastic Barrett's epithelial cells, acid exerts early antiproliferative effects through activation of the Chk2 pathway

Acid exerts pro-proliferative effects in Barrett's-associated esophageal adenocarcinoma cells. In non-neoplastic Barrett's epithelial (BAR-T) cells, in contrast, we have shown that acid exposure has antiproliferative effects. To explore our hypothesis that the acid-induced, antiproliferati...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2007-09, Vol.67 (18), p.8580-8587
Hauptverfasser:	ZHANG, Hui-Ying, XI ZHANG, HORMI-CARVER, Kathy, FEAGINS, Linda A, SPECHLER, Stuart J, SOUZA, Rhonda F
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids - pharmacology Antineoplastic agents Apoptosis - drug effects Barrett Esophagus - enzymology Barrett Esophagus - pathology Biological and medical sciences cdc25 Phosphatases - metabolism Cell Growth Processes - drug effects Cell Line Checkpoint Kinase 2 Cyclin E - metabolism Cyclin-Dependent Kinase Inhibitor p21 - metabolism Enzyme Activation Epithelial Cells - drug effects Epithelial Cells - enzymology Epithelial Cells - pathology G1 Phase - drug effects Gastroesophageal Reflux - complications Gastroesophageal Reflux - enzymology Humans Hydrogen-Ion Concentration Medical sciences Pharmacology. Drug treatments Phosphorylation - drug effects Protein-Serine-Threonine Kinases - antagonists & inhibitors Protein-Serine-Threonine Kinases - metabolism S Phase - drug effects Tumor Suppressor Protein p53 - biosynthesis Tumors
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