MicroRNA-34b and MicroRNA-34c are targets of p53 and cooperate in control of cell proliferation and adhesion-independent growth

MicroRNAs (miRNA) are a recently discovered class of noncoding RNAs that negatively regulate gene expression. Recent evidence indicates that miRNAs may play an important role in cancer. However, the mechanism of their deregulation in neoplastic transformation has only begun to be understood. To eluc...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2007-09, Vol.67 (18), p.8433-8438
Hauptverfasser:	CORNEY, David C, FLESKEN-NIKITIN, Andrea, GODWIN, Andrew K, WEI WANG, NIKITIN, Alexander Yu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Base Sequence Biological and medical sciences Cell Adhesion - genetics Cell Growth Processes - genetics Cell Line, Tumor Female Gene Expression Regulation, Neoplastic Gene Silencing Genes, p53 Humans Medical sciences Mice MicroRNAs - genetics Oligonucleotide Array Sequence Analysis Ovarian Neoplasms - genetics Ovarian Neoplasms - pathology Ovary - cytology Ovary - metabolism Ovary - physiology Pharmacology. Drug treatments Promoter Regions, Genetic Transcription, Genetic Transfection Tumor Suppressor Protein p53 - biosynthesis Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Tumors
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