Stress-induced activation of the AMP-activated protein kinase in the freeze-tolerant frog Rana sylvatica

Survival in the frozen state depends on biochemical adaptations that deal with multiple stresses on cells including long-term ischaemia and tissue dehydration. We investigated whether the AMP-activated protein kinase (AMPK) could play a regulatory role in the metabolic re-sculpting that occurs durin...

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Veröffentlicht in:	Cryobiology 2006-12, Vol.53 (3), p.297-309
Hauptverfasser:	Rider, Mark H., Hussain, Nusrat, Horman, Sandrine, Dilworth, Stephen M., Storey, Kenneth B.
Format:	Artikel
Sprache:	eng
Schlagworte:	4E-BP1 Acclimatization - physiology Acetyl-CoA Carboxylase - chemistry Acetyl-CoA Carboxylase - metabolism AMP-Activated Protein Kinases AMPK Animals Carrier Proteins - chemistry Carrier Proteins - metabolism Cell-Free System eEF2 eEF2K Energy stress Enzyme Activation Freezing Freshwater In Vitro Techniques Male Metabolic rate depression Models, Biological mTOR Multienzyme Complexes - chemistry Multienzyme Complexes - metabolism p70S6K Peptide Elongation Factor 2 - chemistry Peptide Elongation Factor 2 - metabolism Phosphoprotein Phosphatases - chemistry Phosphoprotein Phosphatases - metabolism Phosphorylation Protein Subunits Protein-Serine-Threonine Kinases - chemistry Protein-Serine-Threonine Kinases - metabolism Rana sylvatica Ranidae - physiology Ribosomal protein S6 Ribosomal Protein S6 - chemistry Ribosomal Protein S6 - metabolism
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