Leptin Responsiveness in Chronically Decerebrate Rats

Peripheral infusions of physiological doses of leptin decrease body fat mass, but it is not known whether this results from direct effects on peripheral tissue or activation of central leptin receptors. In this study, we infused chronically decerebrate (CD) rats, in which the forebrain was surgicall...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2007-10, Vol.148 (10), p.4623-4633
Hauptverfasser:	Harris, Ruth B. S, Bartness, Timothy J, Grill, Harvey J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adiponectin Adipose Tissue - drug effects Adipose Tissue - pathology Animals Biological and medical sciences Body Composition - drug effects Body fat Body mass Brain stem Chronic Disease Decerebrate State - complications Decerebrate State - metabolism Decerebrate State - pathology Decerebrate State - physiopathology Eating Energy Energy balance Energy expenditure Energy Metabolism Food intake Forebrain Fundamental and applied biological sciences. Psychology Infusion Pumps Lean body mass Leptin - administration & dosage Leptin - pharmacology Leptin receptors Male Obesity - etiology Oxygen Consumption Physiological effects Prosencephalon - physiology Rats Rats, Sprague-Dawley Testosterone Testosterone - blood Vertebrates: endocrinology
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