Cartilage oligomeric matrix protein (COMP) is modified by intra-articular liposomal clodronate in an experimental model of arthritis
High-dose liposomal bisphosphonates exert apoptotic effects. This work studies the chondroprotective and anti-inflammatory properties of intra-articularly administered low-dose, non-cytotoxic liposomal clodronate. Antigen induced arthritis in rabbits was treated with intra-articular injections of li...
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| Veröffentlicht in: | Clinical and experimental rheumatology 2006-11, Vol.24 (6), p.622-628 |
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| creator | GOMEZ-BARRENA, E LINDROOS, L CEPORNS, A LOPEZ-FRANCO, M SANCHEZ-PERNAUTE, O MONKKONEN, J SALO, J HERRERO-BEAUMONT, G KONTTINEN, Y |
| description | High-dose liposomal bisphosphonates exert apoptotic effects. This work studies the chondroprotective and anti-inflammatory properties of intra-articularly administered low-dose, non-cytotoxic liposomal clodronate.
Antigen induced arthritis in rabbits was treated with intra-articular injections of liposomal clodronate. Drug effects on cartilage oligomeric matrix protein COMP was assessed using immunohistochemistry and morphometry of synovial membrane and hyaline articular cartilage.
COMP remained close to normal in liposomal clodronate treated superficial articular cartilage compared to a significant loss of COMP in arthritis controls treated with empty liposomes. The middle and deep layers of the hyaline articular cartilage were characterized by highly increased COMP expression in liposomal clodronate treated AIA joints compared to controls. In contrast to cartilage, synovial COMP expression was slightly decreased as a result of liposomal clodronate treatment.
Low-dose, non-cytotoxic liposomal clodronate exerts a dichotomous effect on synovial membrane and articular cartilage COMP in the AIA model. COMP is a useful inflammation marker in the synovial tissue, but it also contributes to the structural integrity of the hyaline articular cartilage forming bridges between type II and IX collagens. Enhancement of COMP in clodronate treated AIA cartilage suggests a chondroprotective and anti-inflammatory effect in the inflammatorily damaged and mechanically strained cartilage. |
| format | Article |
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Antigen induced arthritis in rabbits was treated with intra-articular injections of liposomal clodronate. Drug effects on cartilage oligomeric matrix protein COMP was assessed using immunohistochemistry and morphometry of synovial membrane and hyaline articular cartilage.
COMP remained close to normal in liposomal clodronate treated superficial articular cartilage compared to a significant loss of COMP in arthritis controls treated with empty liposomes. The middle and deep layers of the hyaline articular cartilage were characterized by highly increased COMP expression in liposomal clodronate treated AIA joints compared to controls. In contrast to cartilage, synovial COMP expression was slightly decreased as a result of liposomal clodronate treatment.
Low-dose, non-cytotoxic liposomal clodronate exerts a dichotomous effect on synovial membrane and articular cartilage COMP in the AIA model. COMP is a useful inflammation marker in the synovial tissue, but it also contributes to the structural integrity of the hyaline articular cartilage forming bridges between type II and IX collagens. Enhancement of COMP in clodronate treated AIA cartilage suggests a chondroprotective and anti-inflammatory effect in the inflammatorily damaged and mechanically strained cartilage.</description><identifier>ISSN: 0392-856X</identifier><identifier>EISSN: 1593-098X</identifier><identifier>PMID: 17207376</identifier><language>eng</language><publisher>Pisa: Clinical and Experimental Rheumatology</publisher><subject>Animals ; Arthritis, Experimental - drug therapy ; Arthritis, Experimental - etiology ; Arthritis, Experimental - metabolism ; Biological and medical sciences ; Bone Density Conservation Agents - administration & dosage ; Bone Density Conservation Agents - pharmacology ; Bones, joints and connective tissue. Antiinflammatory agents ; Cartilage, Articular - drug effects ; Cartilage, Articular - metabolism ; Cartilage, Articular - pathology ; Clodronic Acid - administration & dosage ; Clodronic Acid - pharmacology ; Disease Models, Animal ; Diseases of the osteoarticular system ; Extracellular Matrix Proteins - immunology ; Extracellular Matrix Proteins - metabolism ; Glycoproteins - immunology ; Glycoproteins - metabolism ; Immunoglobulin G - immunology ; Injections, Intra-Articular ; Liposomes ; Matrilin Proteins ; Medical sciences ; Miscellaneous. Osteoarticular involvement in other diseases ; Pharmacology. Drug treatments ; Rabbits ; Synovial Membrane - drug effects ; Synovial Membrane - metabolism ; Synovial Membrane - pathology</subject><ispartof>Clinical and experimental rheumatology, 2006-11, Vol.24 (6), p.622-628</ispartof><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18505840$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17207376$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>GOMEZ-BARRENA, E</creatorcontrib><creatorcontrib>LINDROOS, L</creatorcontrib><creatorcontrib>CEPORNS, A</creatorcontrib><creatorcontrib>LOPEZ-FRANCO, M</creatorcontrib><creatorcontrib>SANCHEZ-PERNAUTE, O</creatorcontrib><creatorcontrib>MONKKONEN, J</creatorcontrib><creatorcontrib>SALO, J</creatorcontrib><creatorcontrib>HERRERO-BEAUMONT, G</creatorcontrib><creatorcontrib>KONTTINEN, Y</creatorcontrib><title>Cartilage oligomeric matrix protein (COMP) is modified by intra-articular liposomal clodronate in an experimental model of arthritis</title><title>Clinical and experimental rheumatology</title><addtitle>Clin Exp Rheumatol</addtitle><description>High-dose liposomal bisphosphonates exert apoptotic effects. This work studies the chondroprotective and anti-inflammatory properties of intra-articularly administered low-dose, non-cytotoxic liposomal clodronate.
Antigen induced arthritis in rabbits was treated with intra-articular injections of liposomal clodronate. Drug effects on cartilage oligomeric matrix protein COMP was assessed using immunohistochemistry and morphometry of synovial membrane and hyaline articular cartilage.
COMP remained close to normal in liposomal clodronate treated superficial articular cartilage compared to a significant loss of COMP in arthritis controls treated with empty liposomes. The middle and deep layers of the hyaline articular cartilage were characterized by highly increased COMP expression in liposomal clodronate treated AIA joints compared to controls. In contrast to cartilage, synovial COMP expression was slightly decreased as a result of liposomal clodronate treatment.
Low-dose, non-cytotoxic liposomal clodronate exerts a dichotomous effect on synovial membrane and articular cartilage COMP in the AIA model. COMP is a useful inflammation marker in the synovial tissue, but it also contributes to the structural integrity of the hyaline articular cartilage forming bridges between type II and IX collagens. Enhancement of COMP in clodronate treated AIA cartilage suggests a chondroprotective and anti-inflammatory effect in the inflammatorily damaged and mechanically strained cartilage.</description><subject>Animals</subject><subject>Arthritis, Experimental - drug therapy</subject><subject>Arthritis, Experimental - etiology</subject><subject>Arthritis, Experimental - metabolism</subject><subject>Biological and medical sciences</subject><subject>Bone Density Conservation Agents - administration & dosage</subject><subject>Bone Density Conservation Agents - pharmacology</subject><subject>Bones, joints and connective tissue. Antiinflammatory agents</subject><subject>Cartilage, Articular - drug effects</subject><subject>Cartilage, Articular - metabolism</subject><subject>Cartilage, Articular - pathology</subject><subject>Clodronic Acid - administration & dosage</subject><subject>Clodronic Acid - pharmacology</subject><subject>Disease Models, Animal</subject><subject>Diseases of the osteoarticular system</subject><subject>Extracellular Matrix Proteins - immunology</subject><subject>Extracellular Matrix Proteins - metabolism</subject><subject>Glycoproteins - immunology</subject><subject>Glycoproteins - metabolism</subject><subject>Immunoglobulin G - immunology</subject><subject>Injections, Intra-Articular</subject><subject>Liposomes</subject><subject>Matrilin Proteins</subject><subject>Medical sciences</subject><subject>Miscellaneous. Osteoarticular involvement in other diseases</subject><subject>Pharmacology. Drug treatments</subject><subject>Rabbits</subject><subject>Synovial Membrane - drug effects</subject><subject>Synovial Membrane - metabolism</subject><subject>Synovial Membrane - pathology</subject><issn>0392-856X</issn><issn>1593-098X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1LxDAQhoso7rr6FyQXRQ-FNGma9CjFL1DWg8LeyrSdrpG0qUkWdu_-cCOueJrDPO_DvHOQzDNR8pSWanWYzCkvWapEsZolJ95_UMoKUcjjZJZJRiWXxTz5qsAFbWCNxBq9tgM63ZIBgtNbMjkbUI_kqlo-v1wT7clgO91r7EizI3oMDtKfeLsx4IjRk_V2AENaYztnRwgYIQIjwe0UvQOOIW6jAw2xPYnRd6eD9qfJUQ_G49l-LpK3u9vX6iF9Wt4_VjdP6cR4GVKlKOv6XFCFimYg-pLnlNKyV1zkncyobLDpGokcYlHIGOMskzlH2gmMLF8kl7_eWOxzgz7Ug_YtGgMj2o2vC8VUJqmK4Pke3DQDdvUUjwe3q__-FoGLPQC-BdM7GFvt_zklqFA55d9BV3jF</recordid><startdate>20061101</startdate><enddate>20061101</enddate><creator>GOMEZ-BARRENA, E</creator><creator>LINDROOS, L</creator><creator>CEPORNS, A</creator><creator>LOPEZ-FRANCO, M</creator><creator>SANCHEZ-PERNAUTE, O</creator><creator>MONKKONEN, J</creator><creator>SALO, J</creator><creator>HERRERO-BEAUMONT, G</creator><creator>KONTTINEN, Y</creator><general>Clinical and Experimental Rheumatology</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20061101</creationdate><title>Cartilage oligomeric matrix protein (COMP) is modified by intra-articular liposomal clodronate in an experimental model of arthritis</title><author>GOMEZ-BARRENA, E ; LINDROOS, L ; CEPORNS, A ; LOPEZ-FRANCO, M ; SANCHEZ-PERNAUTE, O ; MONKKONEN, J ; SALO, J ; HERRERO-BEAUMONT, G ; KONTTINEN, Y</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p239t-8802df4508e801a5f9340009f8354d7107bebdb7e3a265a122321743e0d5e9343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Animals</topic><topic>Arthritis, Experimental - drug therapy</topic><topic>Arthritis, Experimental - etiology</topic><topic>Arthritis, Experimental - metabolism</topic><topic>Biological and medical sciences</topic><topic>Bone Density Conservation Agents - administration & dosage</topic><topic>Bone Density Conservation Agents - pharmacology</topic><topic>Bones, joints and connective tissue. Antiinflammatory agents</topic><topic>Cartilage, Articular - drug effects</topic><topic>Cartilage, Articular - metabolism</topic><topic>Cartilage, Articular - pathology</topic><topic>Clodronic Acid - administration & dosage</topic><topic>Clodronic Acid - pharmacology</topic><topic>Disease Models, Animal</topic><topic>Diseases of the osteoarticular system</topic><topic>Extracellular Matrix Proteins - immunology</topic><topic>Extracellular Matrix Proteins - metabolism</topic><topic>Glycoproteins - immunology</topic><topic>Glycoproteins - metabolism</topic><topic>Immunoglobulin G - immunology</topic><topic>Injections, Intra-Articular</topic><topic>Liposomes</topic><topic>Matrilin Proteins</topic><topic>Medical sciences</topic><topic>Miscellaneous. Osteoarticular involvement in other diseases</topic><topic>Pharmacology. Drug treatments</topic><topic>Rabbits</topic><topic>Synovial Membrane - drug effects</topic><topic>Synovial Membrane - metabolism</topic><topic>Synovial Membrane - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>GOMEZ-BARRENA, E</creatorcontrib><creatorcontrib>LINDROOS, L</creatorcontrib><creatorcontrib>CEPORNS, A</creatorcontrib><creatorcontrib>LOPEZ-FRANCO, M</creatorcontrib><creatorcontrib>SANCHEZ-PERNAUTE, O</creatorcontrib><creatorcontrib>MONKKONEN, J</creatorcontrib><creatorcontrib>SALO, J</creatorcontrib><creatorcontrib>HERRERO-BEAUMONT, G</creatorcontrib><creatorcontrib>KONTTINEN, Y</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical and experimental rheumatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>GOMEZ-BARRENA, E</au><au>LINDROOS, L</au><au>CEPORNS, A</au><au>LOPEZ-FRANCO, M</au><au>SANCHEZ-PERNAUTE, O</au><au>MONKKONEN, J</au><au>SALO, J</au><au>HERRERO-BEAUMONT, G</au><au>KONTTINEN, Y</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cartilage oligomeric matrix protein (COMP) is modified by intra-articular liposomal clodronate in an experimental model of arthritis</atitle><jtitle>Clinical and experimental rheumatology</jtitle><addtitle>Clin Exp Rheumatol</addtitle><date>2006-11-01</date><risdate>2006</risdate><volume>24</volume><issue>6</issue><spage>622</spage><epage>628</epage><pages>622-628</pages><issn>0392-856X</issn><eissn>1593-098X</eissn><abstract>High-dose liposomal bisphosphonates exert apoptotic effects. This work studies the chondroprotective and anti-inflammatory properties of intra-articularly administered low-dose, non-cytotoxic liposomal clodronate.
Antigen induced arthritis in rabbits was treated with intra-articular injections of liposomal clodronate. Drug effects on cartilage oligomeric matrix protein COMP was assessed using immunohistochemistry and morphometry of synovial membrane and hyaline articular cartilage.
COMP remained close to normal in liposomal clodronate treated superficial articular cartilage compared to a significant loss of COMP in arthritis controls treated with empty liposomes. The middle and deep layers of the hyaline articular cartilage were characterized by highly increased COMP expression in liposomal clodronate treated AIA joints compared to controls. In contrast to cartilage, synovial COMP expression was slightly decreased as a result of liposomal clodronate treatment.
Low-dose, non-cytotoxic liposomal clodronate exerts a dichotomous effect on synovial membrane and articular cartilage COMP in the AIA model. COMP is a useful inflammation marker in the synovial tissue, but it also contributes to the structural integrity of the hyaline articular cartilage forming bridges between type II and IX collagens. Enhancement of COMP in clodronate treated AIA cartilage suggests a chondroprotective and anti-inflammatory effect in the inflammatorily damaged and mechanically strained cartilage.</abstract><cop>Pisa</cop><pub>Clinical and Experimental Rheumatology</pub><pmid>17207376</pmid><tpages>7</tpages></addata></record> |
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| ispartof | Clinical and experimental rheumatology, 2006-11, Vol.24 (6), p.622-628 |
| issn | 0392-856X 1593-098X |
| language | eng |
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| subjects | Animals Arthritis, Experimental - drug therapy Arthritis, Experimental - etiology Arthritis, Experimental - metabolism Biological and medical sciences Bone Density Conservation Agents - administration & dosage Bone Density Conservation Agents - pharmacology Bones, joints and connective tissue. Antiinflammatory agents Cartilage, Articular - drug effects Cartilage, Articular - metabolism Cartilage, Articular - pathology Clodronic Acid - administration & dosage Clodronic Acid - pharmacology Disease Models, Animal Diseases of the osteoarticular system Extracellular Matrix Proteins - immunology Extracellular Matrix Proteins - metabolism Glycoproteins - immunology Glycoproteins - metabolism Immunoglobulin G - immunology Injections, Intra-Articular Liposomes Matrilin Proteins Medical sciences Miscellaneous. Osteoarticular involvement in other diseases Pharmacology. Drug treatments Rabbits Synovial Membrane - drug effects Synovial Membrane - metabolism Synovial Membrane - pathology |
| title | Cartilage oligomeric matrix protein (COMP) is modified by intra-articular liposomal clodronate in an experimental model of arthritis |
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