feline immunodeficiency virus vif-deletion mutant remains attenuated upon infection of newborn kittens

This report characterizes lentivirus attenuation associated with a vif mutation by inoculation of newborn kittens with a vif-deleted feline immunodeficiency virus provirus plasmid (FIV-pPPRdeltavif). Virus in peripheral blood, antiviral antibody or CD4 T-cell count alterations were not detected in k...

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Veröffentlicht in:	Journal of general virology 2007-10, Vol.88 (10), p.2793-2799
Hauptverfasser:	Shen, X, Leutenegger, C.M, Cole, K.S, Pedersen, N.C, Sparger, E.E
Format:	Artikel
Sprache:	eng
Schlagworte:	accessory genes animal age Animals Animals, Newborn antibodies Antibodies, Viral - blood attenuated viruses Biological and medical sciences Cats - virology CD4-positive T-lymphocytes CD4-Positive T-Lymphocytes - immunology Feline Acquired Immunodeficiency Syndrome - immunology Feline Acquired Immunodeficiency Syndrome - prevention & control Feline immunodeficiency virus Fundamental and applied biological sciences. Psychology Gene Deletion Gene Products, vif - deficiency Gene Products, vif - genetics genes Genome, Viral immune response Immunodeficiency Virus, Feline - genetics Immunodeficiency Virus, Feline - physiology kittens lymphocyte count lymphocyte proliferation microbial genetics Microbiology Miscellaneous mutants Mutation neonates pathogenicity pets plasmids viral diseases of animals and humans Virology Virus Replication
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