Young adult reference ranges for thyroid function tests on the Centaur immunoassay analyser
This study aims to establish reference ranges for thyroid tests in young Saudi adults using the Centaur immunoassay method. Physical examination is performed and thyroid function tests include thyroid stimulating hormone (TSH), free thyroxine (FT4) and free triiodothyronine (FT3). These are performe...
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| Veröffentlicht in: | British journal of biomedical science 2006-01, Vol.63 (4), p.163-165 |
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| creator | Alqahatani, M. Tamimi, W. Aldaker, M Alenzi, F. Tamim, H. Alsadhan, A. |
| description | This study aims to establish reference ranges for thyroid tests in young Saudi adults using the Centaur immunoassay method. Physical examination is performed and thyroid function tests include thyroid stimulating hormone (TSH), free thyroxine (FT4) and free triiodothyronine (FT3). These are performed on 291 young Saudi adults (182 [63%] females and 109 [37%] males; average age: 27 years [range 18-50]). Clinical thyroid abnormality, related symptoms and/or abnormal thyroid function tests exclude a person from the study and thus a total of 276 subjects (171 [62%] females and 105 [38%] males) are used to establish the new reference ranges. Combined female and male ranges for TSH, FT4, and FT3 were found to be 0.48-6.30 miu/L (9.00-18.62 pmol/L and 3.39-6.85 pmol/L, respectively). Mean TSH and FT4 levels were significantly different (P |
| doi_str_mv | 10.1080/09674845.2006.11732744 |
| format | Article |
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Physical examination is performed and thyroid function tests include thyroid stimulating hormone (TSH), free thyroxine (FT4) and free triiodothyronine (FT3). These are performed on 291 young Saudi adults (182 [63%] females and 109 [37%] males; average age: 27 years [range 18-50]). Clinical thyroid abnormality, related symptoms and/or abnormal thyroid function tests exclude a person from the study and thus a total of 276 subjects (171 [62%] females and 105 [38%] males) are used to establish the new reference ranges. Combined female and male ranges for TSH, FT4, and FT3 were found to be 0.48-6.30 miu/L (9.00-18.62 pmol/L and 3.39-6.85 pmol/L, respectively). Mean TSH and FT4 levels were significantly different (P<0.0001) from those quoted by the manufacturer. Ranges for TSH were 0.48-6.30 miu/L (female) and 0.52-4.89 miu/L (male) (P=0.08). Female ranges for FT4 and FT3 were 9.00-17.15 pmol/L and 3.39-5.82 pmol/L, respectively. Male ranges were 9.92-18.62 pmol/L (P=0.0001) and 4.36-6.85 pmol/L (P<0.0001). The range of TSH levels in the young local Saudi population proved to be higher than that quoted by the manufacturer. FT4 range was lower and narrower than that quoted by the manufacturer. Significant differences between female and male populations suggest that partitioning of the reference ranges by gender is necessary.</description><identifier>ISSN: 0967-4845</identifier><identifier>EISSN: 2474-0896</identifier><identifier>DOI: 10.1080/09674845.2006.11732744</identifier><identifier>PMID: 17201204</identifier><language>eng</language><publisher>England: Taylor & Francis</publisher><subject>Adult ; Biological variation ; Confidence intervals ; Endocrinology ; Female ; Females ; Hormones ; Hospitals ; Humans ; Hypothyroidism ; Immunoassay ; Informed consent ; Iron ; Male ; Males ; Middle Aged ; Physical examinations ; Population ; Reference Values ; Saudi Arabia ; Sex Factors ; Standard deviation ; Students ; Thyroid diseases ; Thyroid Diseases - diagnosis ; Thyroid Function Tests - standards ; Thyroid gland ; Thyroid Hormones - blood ; Thyrotropin ; Thyrotropin - blood ; Thyroxine ; Thyroxine - blood ; Triiodothyronine ; Triiodothyronine - blood ; Vital signs ; Young adults</subject><ispartof>British journal of biomedical science, 2006-01, Vol.63 (4), p.163-165</ispartof><rights>Copyright 2006 Taylor and Francis Group LLC 2006</rights><rights>Copyright Step Communications Ltd. 2006</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c394t-9a97fa16e4409c2a800fbbd23f771560d0b83033ee9f25919d3194220de25ce83</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17201204$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Alqahatani, M.</creatorcontrib><creatorcontrib>Tamimi, W.</creatorcontrib><creatorcontrib>Aldaker, M</creatorcontrib><creatorcontrib>Alenzi, F.</creatorcontrib><creatorcontrib>Tamim, H.</creatorcontrib><creatorcontrib>Alsadhan, A.</creatorcontrib><title>Young adult reference ranges for thyroid function tests on the Centaur immunoassay analyser</title><title>British journal of biomedical science</title><addtitle>Br J Biomed Sci</addtitle><description>This study aims to establish reference ranges for thyroid tests in young Saudi adults using the Centaur immunoassay method. Physical examination is performed and thyroid function tests include thyroid stimulating hormone (TSH), free thyroxine (FT4) and free triiodothyronine (FT3). These are performed on 291 young Saudi adults (182 [63%] females and 109 [37%] males; average age: 27 years [range 18-50]). Clinical thyroid abnormality, related symptoms and/or abnormal thyroid function tests exclude a person from the study and thus a total of 276 subjects (171 [62%] females and 105 [38%] males) are used to establish the new reference ranges. Combined female and male ranges for TSH, FT4, and FT3 were found to be 0.48-6.30 miu/L (9.00-18.62 pmol/L and 3.39-6.85 pmol/L, respectively). Mean TSH and FT4 levels were significantly different (P<0.0001) from those quoted by the manufacturer. Ranges for TSH were 0.48-6.30 miu/L (female) and 0.52-4.89 miu/L (male) (P=0.08). Female ranges for FT4 and FT3 were 9.00-17.15 pmol/L and 3.39-5.82 pmol/L, respectively. Male ranges were 9.92-18.62 pmol/L (P=0.0001) and 4.36-6.85 pmol/L (P<0.0001). The range of TSH levels in the young local Saudi population proved to be higher than that quoted by the manufacturer. FT4 range was lower and narrower than that quoted by the manufacturer. Significant differences between female and male populations suggest that partitioning of the reference ranges by gender is necessary.</description><subject>Adult</subject><subject>Biological variation</subject><subject>Confidence intervals</subject><subject>Endocrinology</subject><subject>Female</subject><subject>Females</subject><subject>Hormones</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Hypothyroidism</subject><subject>Immunoassay</subject><subject>Informed consent</subject><subject>Iron</subject><subject>Male</subject><subject>Males</subject><subject>Middle Aged</subject><subject>Physical examinations</subject><subject>Population</subject><subject>Reference Values</subject><subject>Saudi Arabia</subject><subject>Sex Factors</subject><subject>Standard deviation</subject><subject>Students</subject><subject>Thyroid diseases</subject><subject>Thyroid Diseases - diagnosis</subject><subject>Thyroid Function Tests - standards</subject><subject>Thyroid gland</subject><subject>Thyroid Hormones - blood</subject><subject>Thyrotropin</subject><subject>Thyrotropin - blood</subject><subject>Thyroxine</subject><subject>Thyroxine - blood</subject><subject>Triiodothyronine</subject><subject>Triiodothyronine - blood</subject><subject>Vital signs</subject><subject>Young adults</subject><issn>0967-4845</issn><issn>2474-0896</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkE2LFDEQhoMo7jj6F5bgwVuPlY9OOsdl8AsWvOhBPIRMd2W3l-5kTTpI_3vTzCyCF09Vh6fqfXkIuWZwYNDBezBKy062Bw6gDoxpwbWUz8iOSy0b6Ix6TnYb1GzUFXmV8wMAM1yrl-SKaQ6Mg9yRnz9iCXfUDWVaaEKPCUOPNLlwh5n6mOhyv6Y4DtSX0C9jDHTBvGS6LfdIjxgWVxId57mE6HJ2K3XBTWvG9Jq88G7K-OYy9-T7xw_fjp-b26-fvhxvbpteGLk0xhntHVMoJZieuw7An04DF15r1ioY4NQJEALReN4aZgbBjOQcBuRtj53Yk3fnv48p_iq1nZ3H3OM0uYCxZKs63kELqoJv_wEfYkm1bbac606DrDl7os5Qn2LOVYl9TOPs0moZ2M29fXJvN_f2yX09vL58L6cZh79nF9kVuDkDY6hiZ_c7pmmwi1unmHw13o_Ziv-E_AGXOJNT</recordid><startdate>20060101</startdate><enddate>20060101</enddate><creator>Alqahatani, M.</creator><creator>Tamimi, W.</creator><creator>Aldaker, M</creator><creator>Alenzi, F.</creator><creator>Tamim, H.</creator><creator>Alsadhan, A.</creator><general>Taylor & Francis</general><general>Taylor & Francis Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>4T-</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>EHMNL</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope></search><sort><creationdate>20060101</creationdate><title>Young adult reference ranges for thyroid function tests on the Centaur immunoassay analyser</title><author>Alqahatani, M. ; Tamimi, W. ; Aldaker, M ; Alenzi, F. ; Tamim, H. ; Alsadhan, A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c394t-9a97fa16e4409c2a800fbbd23f771560d0b83033ee9f25919d3194220de25ce83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adult</topic><topic>Biological variation</topic><topic>Confidence intervals</topic><topic>Endocrinology</topic><topic>Female</topic><topic>Females</topic><topic>Hormones</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Hypothyroidism</topic><topic>Immunoassay</topic><topic>Informed consent</topic><topic>Iron</topic><topic>Male</topic><topic>Males</topic><topic>Middle Aged</topic><topic>Physical examinations</topic><topic>Population</topic><topic>Reference Values</topic><topic>Saudi Arabia</topic><topic>Sex Factors</topic><topic>Standard deviation</topic><topic>Students</topic><topic>Thyroid diseases</topic><topic>Thyroid Diseases - diagnosis</topic><topic>Thyroid Function Tests - standards</topic><topic>Thyroid gland</topic><topic>Thyroid Hormones - blood</topic><topic>Thyrotropin</topic><topic>Thyrotropin - blood</topic><topic>Thyroxine</topic><topic>Thyroxine - blood</topic><topic>Triiodothyronine</topic><topic>Triiodothyronine - blood</topic><topic>Vital signs</topic><topic>Young adults</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Alqahatani, M.</creatorcontrib><creatorcontrib>Tamimi, W.</creatorcontrib><creatorcontrib>Aldaker, M</creatorcontrib><creatorcontrib>Alenzi, F.</creatorcontrib><creatorcontrib>Tamim, H.</creatorcontrib><creatorcontrib>Alsadhan, A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Docstoc</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>UK & Ireland Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of biomedical science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alqahatani, M.</au><au>Tamimi, W.</au><au>Aldaker, M</au><au>Alenzi, F.</au><au>Tamim, H.</au><au>Alsadhan, A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Young adult reference ranges for thyroid function tests on the Centaur immunoassay analyser</atitle><jtitle>British journal of biomedical science</jtitle><addtitle>Br J Biomed Sci</addtitle><date>2006-01-01</date><risdate>2006</risdate><volume>63</volume><issue>4</issue><spage>163</spage><epage>165</epage><pages>163-165</pages><issn>0967-4845</issn><eissn>2474-0896</eissn><abstract>This study aims to establish reference ranges for thyroid tests in young Saudi adults using the Centaur immunoassay method. Physical examination is performed and thyroid function tests include thyroid stimulating hormone (TSH), free thyroxine (FT4) and free triiodothyronine (FT3). These are performed on 291 young Saudi adults (182 [63%] females and 109 [37%] males; average age: 27 years [range 18-50]). Clinical thyroid abnormality, related symptoms and/or abnormal thyroid function tests exclude a person from the study and thus a total of 276 subjects (171 [62%] females and 105 [38%] males) are used to establish the new reference ranges. Combined female and male ranges for TSH, FT4, and FT3 were found to be 0.48-6.30 miu/L (9.00-18.62 pmol/L and 3.39-6.85 pmol/L, respectively). Mean TSH and FT4 levels were significantly different (P<0.0001) from those quoted by the manufacturer. Ranges for TSH were 0.48-6.30 miu/L (female) and 0.52-4.89 miu/L (male) (P=0.08). Female ranges for FT4 and FT3 were 9.00-17.15 pmol/L and 3.39-5.82 pmol/L, respectively. Male ranges were 9.92-18.62 pmol/L (P=0.0001) and 4.36-6.85 pmol/L (P<0.0001). The range of TSH levels in the young local Saudi population proved to be higher than that quoted by the manufacturer. FT4 range was lower and narrower than that quoted by the manufacturer. Significant differences between female and male populations suggest that partitioning of the reference ranges by gender is necessary.</abstract><cop>England</cop><pub>Taylor & Francis</pub><pmid>17201204</pmid><doi>10.1080/09674845.2006.11732744</doi><tpages>3</tpages></addata></record> |
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| subjects | Adult Biological variation Confidence intervals Endocrinology Female Females Hormones Hospitals Humans Hypothyroidism Immunoassay Informed consent Iron Male Males Middle Aged Physical examinations Population Reference Values Saudi Arabia Sex Factors Standard deviation Students Thyroid diseases Thyroid Diseases - diagnosis Thyroid Function Tests - standards Thyroid gland Thyroid Hormones - blood Thyrotropin Thyrotropin - blood Thyroxine Thyroxine - blood Triiodothyronine Triiodothyronine - blood Vital signs Young adults |
| title | Young adult reference ranges for thyroid function tests on the Centaur immunoassay analyser |
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