Correlation of GLUT-1 overexpression, tumor size, and depth of invasion with 18F-2-fluoro-2-deoxy-d-glucose uptake by positron emission tomography in colorectal cancer
We investigated the wide variability of 18F-2-fluoro-2-deoxy-D: -glucose (FDG) uptake, semiquantified as standardized uptake value (SUV), in positron emission tomography (PET) scanning, in 20 patients with colorectal cancer (CRC), including 1 with synchronous hepatic metastasis. The sensitivity of P...
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| Veröffentlicht in: | Digestive diseases and sciences 2006-12, Vol.51 (12), p.2198-2205 |
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| creator | JINYU GU YAMAMOTO, Hirofumi MONDEN, Morito FUKUNAGA, Hiroki DANNO, Katsuki TAKEMASA, Ichiro MASATAKA, Ikeda TATSUMI, Mitsuaki SEKIMOTO, Mitsugu HATAZAWA, Jun NISHIMURA, Tsunehiko |
| description | We investigated the wide variability of 18F-2-fluoro-2-deoxy-D: -glucose (FDG) uptake, semiquantified as standardized uptake value (SUV), in positron emission tomography (PET) scanning, in 20 patients with colorectal cancer (CRC), including 1 with synchronous hepatic metastasis. The sensitivity of PET in CRC diagnosis was 100%, with a mean SUV of 8.0 (3.1-11.9). Tumor size and depth of invasion were associated with higher SUVs (P=.0004, .042, respectively). Strong glucose transporter-1 (GLUT-1) expression had significantly positive correlation with the SUV (r=.619, P=.003). GLUT-1 expression revealed positive staining in 17 (85%) of the 20 primary lesions. The central part of the tumor, thought to be relatively hypoxic, had stronger GLUT-1 expression and a higher SUV than the periphery, in both the primary tumor and hepatic metastatic foci. Our data suggest that the SUVs of FDG uptake in PET may be a noninvasive biomarker for advanced CRC, indicative of a large hypoxic tumor with deep invasion. |
| doi_str_mv | 10.1007/s10620-006-9428-2 |
| format | Article |
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The sensitivity of PET in CRC diagnosis was 100%, with a mean SUV of 8.0 (3.1-11.9). Tumor size and depth of invasion were associated with higher SUVs (P=.0004, .042, respectively). Strong glucose transporter-1 (GLUT-1) expression had significantly positive correlation with the SUV (r=.619, P=.003). GLUT-1 expression revealed positive staining in 17 (85%) of the 20 primary lesions. The central part of the tumor, thought to be relatively hypoxic, had stronger GLUT-1 expression and a higher SUV than the periphery, in both the primary tumor and hepatic metastatic foci. Our data suggest that the SUVs of FDG uptake in PET may be a noninvasive biomarker for advanced CRC, indicative of a large hypoxic tumor with deep invasion.</description><identifier>ISSN: 0163-2116</identifier><identifier>EISSN: 1573-2568</identifier><identifier>DOI: 10.1007/s10620-006-9428-2</identifier><identifier>PMID: 17080242</identifier><identifier>CODEN: DDSCDJ</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Adenocarcinoma - diagnostic imaging ; Adenocarcinoma - genetics ; Adenocarcinoma - metabolism ; Adenocarcinoma - secondary ; Aged ; Biological and medical sciences ; Biomarkers, Tumor - metabolism ; Colorectal cancer ; Colorectal Neoplasms - diagnostic imaging ; Colorectal Neoplasms - genetics ; Colorectal Neoplasms - metabolism ; Colorectal Neoplasms - pathology ; Disease Progression ; Female ; Fluorodeoxyglucose F18 - pharmacokinetics ; Gastroenterology. Liver. Pancreas. Abdomen ; Gene Expression Regulation, Neoplastic ; Glucose ; Glucose Transporter Type 1 - genetics ; Glucose Transporter Type 1 - metabolism ; Humans ; Hypoxia ; Liver Neoplasms - diagnostic imaging ; Liver Neoplasms - metabolism ; Liver Neoplasms - secondary ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Male ; Medical sciences ; Middle Aged ; Neoplasm Invasiveness ; Positron-Emission Tomography ; Prognosis ; Radiopharmaceuticals - pharmacokinetics ; Sensitivity and Specificity ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Tomography ; Tumors</subject><ispartof>Digestive diseases and sciences, 2006-12, Vol.51 (12), p.2198-2205</ispartof><rights>2007 INIST-CNRS</rights><rights>Springer Science+Business Media, LLC 2006</rights><rights>Springer Science+Business Media, Inc. 2006.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c384t-219cf4d100f2862d55dcd33e44a452a9d7e081f79b205b16db88b58e772675823</citedby><cites>FETCH-LOGICAL-c384t-219cf4d100f2862d55dcd33e44a452a9d7e081f79b205b16db88b58e772675823</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18445992$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17080242$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>JINYU GU</creatorcontrib><creatorcontrib>YAMAMOTO, Hirofumi</creatorcontrib><creatorcontrib>MONDEN, Morito</creatorcontrib><creatorcontrib>FUKUNAGA, Hiroki</creatorcontrib><creatorcontrib>DANNO, Katsuki</creatorcontrib><creatorcontrib>TAKEMASA, Ichiro</creatorcontrib><creatorcontrib>MASATAKA, Ikeda</creatorcontrib><creatorcontrib>TATSUMI, Mitsuaki</creatorcontrib><creatorcontrib>SEKIMOTO, Mitsugu</creatorcontrib><creatorcontrib>HATAZAWA, Jun</creatorcontrib><creatorcontrib>NISHIMURA, Tsunehiko</creatorcontrib><title>Correlation of GLUT-1 overexpression, tumor size, and depth of invasion with 18F-2-fluoro-2-deoxy-d-glucose uptake by positron emission tomography in colorectal cancer</title><title>Digestive diseases and sciences</title><addtitle>Dig Dis Sci</addtitle><description>We investigated the wide variability of 18F-2-fluoro-2-deoxy-D: -glucose (FDG) uptake, semiquantified as standardized uptake value (SUV), in positron emission tomography (PET) scanning, in 20 patients with colorectal cancer (CRC), including 1 with synchronous hepatic metastasis. The sensitivity of PET in CRC diagnosis was 100%, with a mean SUV of 8.0 (3.1-11.9). Tumor size and depth of invasion were associated with higher SUVs (P=.0004, .042, respectively). Strong glucose transporter-1 (GLUT-1) expression had significantly positive correlation with the SUV (r=.619, P=.003). GLUT-1 expression revealed positive staining in 17 (85%) of the 20 primary lesions. The central part of the tumor, thought to be relatively hypoxic, had stronger GLUT-1 expression and a higher SUV than the periphery, in both the primary tumor and hepatic metastatic foci. Our data suggest that the SUVs of FDG uptake in PET may be a noninvasive biomarker for advanced CRC, indicative of a large hypoxic tumor with deep invasion.</description><subject>Adenocarcinoma - diagnostic imaging</subject><subject>Adenocarcinoma - genetics</subject><subject>Adenocarcinoma - metabolism</subject><subject>Adenocarcinoma - secondary</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Colorectal cancer</subject><subject>Colorectal Neoplasms - diagnostic imaging</subject><subject>Colorectal Neoplasms - genetics</subject><subject>Colorectal Neoplasms - metabolism</subject><subject>Colorectal Neoplasms - pathology</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Fluorodeoxyglucose F18 - pharmacokinetics</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Glucose</subject><subject>Glucose Transporter Type 1 - genetics</subject><subject>Glucose Transporter Type 1 - metabolism</subject><subject>Humans</subject><subject>Hypoxia</subject><subject>Liver Neoplasms - diagnostic imaging</subject><subject>Liver Neoplasms - metabolism</subject><subject>Liver Neoplasms - secondary</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neoplasm Invasiveness</subject><subject>Positron-Emission Tomography</subject><subject>Prognosis</subject><subject>Radiopharmaceuticals - pharmacokinetics</subject><subject>Sensitivity and Specificity</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. 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Liver. Pancreas. Abdomen</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Glucose</topic><topic>Glucose Transporter Type 1 - genetics</topic><topic>Glucose Transporter Type 1 - metabolism</topic><topic>Humans</topic><topic>Hypoxia</topic><topic>Liver Neoplasms - diagnostic imaging</topic><topic>Liver Neoplasms - metabolism</topic><topic>Liver Neoplasms - secondary</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neoplasm Invasiveness</topic><topic>Positron-Emission Tomography</topic><topic>Prognosis</topic><topic>Radiopharmaceuticals - pharmacokinetics</topic><topic>Sensitivity and Specificity</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Tomography</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>JINYU GU</creatorcontrib><creatorcontrib>YAMAMOTO, Hirofumi</creatorcontrib><creatorcontrib>MONDEN, Morito</creatorcontrib><creatorcontrib>FUKUNAGA, Hiroki</creatorcontrib><creatorcontrib>DANNO, Katsuki</creatorcontrib><creatorcontrib>TAKEMASA, Ichiro</creatorcontrib><creatorcontrib>MASATAKA, Ikeda</creatorcontrib><creatorcontrib>TATSUMI, Mitsuaki</creatorcontrib><creatorcontrib>SEKIMOTO, Mitsugu</creatorcontrib><creatorcontrib>HATAZAWA, Jun</creatorcontrib><creatorcontrib>NISHIMURA, Tsunehiko</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Digestive diseases and sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>JINYU GU</au><au>YAMAMOTO, Hirofumi</au><au>MONDEN, Morito</au><au>FUKUNAGA, Hiroki</au><au>DANNO, Katsuki</au><au>TAKEMASA, Ichiro</au><au>MASATAKA, Ikeda</au><au>TATSUMI, Mitsuaki</au><au>SEKIMOTO, Mitsugu</au><au>HATAZAWA, Jun</au><au>NISHIMURA, Tsunehiko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Correlation of GLUT-1 overexpression, tumor size, and depth of invasion with 18F-2-fluoro-2-deoxy-d-glucose uptake by positron emission tomography in colorectal cancer</atitle><jtitle>Digestive diseases and sciences</jtitle><addtitle>Dig Dis Sci</addtitle><date>2006-12-01</date><risdate>2006</risdate><volume>51</volume><issue>12</issue><spage>2198</spage><epage>2205</epage><pages>2198-2205</pages><issn>0163-2116</issn><eissn>1573-2568</eissn><coden>DDSCDJ</coden><abstract>We investigated the wide variability of 18F-2-fluoro-2-deoxy-D: -glucose (FDG) uptake, semiquantified as standardized uptake value (SUV), in positron emission tomography (PET) scanning, in 20 patients with colorectal cancer (CRC), including 1 with synchronous hepatic metastasis. The sensitivity of PET in CRC diagnosis was 100%, with a mean SUV of 8.0 (3.1-11.9). Tumor size and depth of invasion were associated with higher SUVs (P=.0004, .042, respectively). Strong glucose transporter-1 (GLUT-1) expression had significantly positive correlation with the SUV (r=.619, P=.003). GLUT-1 expression revealed positive staining in 17 (85%) of the 20 primary lesions. The central part of the tumor, thought to be relatively hypoxic, had stronger GLUT-1 expression and a higher SUV than the periphery, in both the primary tumor and hepatic metastatic foci. Our data suggest that the SUVs of FDG uptake in PET may be a noninvasive biomarker for advanced CRC, indicative of a large hypoxic tumor with deep invasion.</abstract><cop>Heidelberg</cop><pub>Springer</pub><pmid>17080242</pmid><doi>10.1007/s10620-006-9428-2</doi><tpages>8</tpages></addata></record> |
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| subjects | Adenocarcinoma - diagnostic imaging Adenocarcinoma - genetics Adenocarcinoma - metabolism Adenocarcinoma - secondary Aged Biological and medical sciences Biomarkers, Tumor - metabolism Colorectal cancer Colorectal Neoplasms - diagnostic imaging Colorectal Neoplasms - genetics Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology Disease Progression Female Fluorodeoxyglucose F18 - pharmacokinetics Gastroenterology. Liver. Pancreas. Abdomen Gene Expression Regulation, Neoplastic Glucose Glucose Transporter Type 1 - genetics Glucose Transporter Type 1 - metabolism Humans Hypoxia Liver Neoplasms - diagnostic imaging Liver Neoplasms - metabolism Liver Neoplasms - secondary Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Middle Aged Neoplasm Invasiveness Positron-Emission Tomography Prognosis Radiopharmaceuticals - pharmacokinetics Sensitivity and Specificity Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tomography Tumors |
| title | Correlation of GLUT-1 overexpression, tumor size, and depth of invasion with 18F-2-fluoro-2-deoxy-d-glucose uptake by positron emission tomography in colorectal cancer |
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