Atherosclerosis in haemodialysis patients without significant comorbidities: Determinants of progression
Aim: The aim of this prospective study was to assess the determinants of the progression of carotid artery intima‐media thickness (CA‐IMT) for 1 year in haemodialysis (HD) patients without significant comorbidities. Methods: Fifty‐four HD patients younger than 55 years, without diabetes, obesity a...
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| Veröffentlicht in: | Nephrology (Carlton, Vic.) Vic.), 2006-12, Vol.11 (6), p.489-493 |
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| creator | ZUMRUTDAL, AYSEGUL DEMIRCAN, SENOL SEYDAOGLU, GULSAH SINGAN, METIN SEZER, SIREN OZDEMIR, F NURHAN HABERAL, MEHMET |
| description | Aim: The aim of this prospective study was to assess the determinants of the progression of carotid artery intima‐media thickness (CA‐IMT) for 1 year in haemodialysis (HD) patients without significant comorbidities.
Methods: Fifty‐four HD patients younger than 55 years, without diabetes, obesity and any clinical evidence of cardiovascular disease (29 men, 25 women; mean age 33.3 ± 10 years; mean time on HD 49.4 ± 43 months) were included in the 1‐year study. CA‐IMT was assessed at baseline and after 12 months. The difference in IMT between these two points of time was calculated (ΔCA‐IMT). C‐reactive protein (CRP), erythrocyte sedimentation rate (ESR), haematocrit‐corrected ESR, beta‐2 microglobulin, cardiac troponin I, lipid profile, fibrinogen, homocysteine, CaXP product, intact parathyroid hormone, haematocrit, albumin, uric acid levels, anthropometric parameters (age, body mass index), smoking, hypertension and left ventricular hypertrophy were recorded at baseline.
Results: The mean value for CA‐IMT at baseline (0.59 ± 0.05 mm) was significantly lower than that at 12 months (0.64 ± 0.07 mm) (P |
| doi_str_mv | 10.1111/j.1440-1797.2006.00694.x |
| format | Article |
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Methods: Fifty‐four HD patients younger than 55 years, without diabetes, obesity and any clinical evidence of cardiovascular disease (29 men, 25 women; mean age 33.3 ± 10 years; mean time on HD 49.4 ± 43 months) were included in the 1‐year study. CA‐IMT was assessed at baseline and after 12 months. The difference in IMT between these two points of time was calculated (ΔCA‐IMT). C‐reactive protein (CRP), erythrocyte sedimentation rate (ESR), haematocrit‐corrected ESR, beta‐2 microglobulin, cardiac troponin I, lipid profile, fibrinogen, homocysteine, CaXP product, intact parathyroid hormone, haematocrit, albumin, uric acid levels, anthropometric parameters (age, body mass index), smoking, hypertension and left ventricular hypertrophy were recorded at baseline.
Results: The mean value for CA‐IMT at baseline (0.59 ± 0.05 mm) was significantly lower than that at 12 months (0.64 ± 0.07 mm) (P < 0.001). CA‐IMT had increased in 41 patients (75.9%). Age (P = 0.02), CRP (P = 0.03), beta‐2 microglobulin (P = 0.001) and left ventricular hypertrophy (P = 0.01) were independently related with CA‐IMT at baseline. Age (P = 0.003) and CRP (P = 0.04) were the independent variables related with CA‐IMT, measured at 12 months. ΔCA‐IMT correlated positively with age (r = 0.31, P < 0.05). Age and sex were independent predictors of ΔCA‐IMT (R2 for the model 0.56).
Conclusion: In addition to age and male sex, non‐specific inflammation may have a possible role in the progression of atherosclerosis in HD patients without significant comorbidities.</description><identifier>ISSN: 1320-5358</identifier><identifier>EISSN: 1440-1797</identifier><identifier>DOI: 10.1111/j.1440-1797.2006.00694.x</identifier><identifier>PMID: 17199784</identifier><language>eng</language><publisher>Melbourne, Australia: Blackwell Publishing Asia</publisher><subject>Adult ; Age Distribution ; atherosclerosis ; Atherosclerosis - diagnostic imaging ; Atherosclerosis - epidemiology ; C-reactive protein ; C-Reactive Protein - metabolism ; Carotid Arteries - diagnostic imaging ; carotid artery intima-media thickness ; Comorbidity ; Disease Progression ; Female ; haemodialysis ; Humans ; inflammation ; Kidney Failure, Chronic - epidemiology ; Kidney Failure, Chronic - therapy ; Male ; Middle Aged ; Prospective Studies ; Renal Dialysis - statistics & numerical data ; Risk Factors ; Sex Distribution ; Tunica Intima - diagnostic imaging ; Tunica Media - diagnostic imaging ; Ultrasonography ; Vasculitis - epidemiology</subject><ispartof>Nephrology (Carlton, Vic.), 2006-12, Vol.11 (6), p.489-493</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4044-2957f03e3f53c20f912d36a6e8a5deeeeb520da7f7cb1c0b436f2399be7071e63</citedby><cites>FETCH-LOGICAL-c4044-2957f03e3f53c20f912d36a6e8a5deeeeb520da7f7cb1c0b436f2399be7071e63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1440-1797.2006.00694.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1440-1797.2006.00694.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17199784$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ZUMRUTDAL, AYSEGUL</creatorcontrib><creatorcontrib>DEMIRCAN, SENOL</creatorcontrib><creatorcontrib>SEYDAOGLU, GULSAH</creatorcontrib><creatorcontrib>SINGAN, METIN</creatorcontrib><creatorcontrib>SEZER, SIREN</creatorcontrib><creatorcontrib>OZDEMIR, F NURHAN</creatorcontrib><creatorcontrib>HABERAL, MEHMET</creatorcontrib><title>Atherosclerosis in haemodialysis patients without significant comorbidities: Determinants of progression</title><title>Nephrology (Carlton, Vic.)</title><addtitle>Nephrology (Carlton)</addtitle><description>Aim: The aim of this prospective study was to assess the determinants of the progression of carotid artery intima‐media thickness (CA‐IMT) for 1 year in haemodialysis (HD) patients without significant comorbidities.
Methods: Fifty‐four HD patients younger than 55 years, without diabetes, obesity and any clinical evidence of cardiovascular disease (29 men, 25 women; mean age 33.3 ± 10 years; mean time on HD 49.4 ± 43 months) were included in the 1‐year study. CA‐IMT was assessed at baseline and after 12 months. The difference in IMT between these two points of time was calculated (ΔCA‐IMT). C‐reactive protein (CRP), erythrocyte sedimentation rate (ESR), haematocrit‐corrected ESR, beta‐2 microglobulin, cardiac troponin I, lipid profile, fibrinogen, homocysteine, CaXP product, intact parathyroid hormone, haematocrit, albumin, uric acid levels, anthropometric parameters (age, body mass index), smoking, hypertension and left ventricular hypertrophy were recorded at baseline.
Results: The mean value for CA‐IMT at baseline (0.59 ± 0.05 mm) was significantly lower than that at 12 months (0.64 ± 0.07 mm) (P < 0.001). CA‐IMT had increased in 41 patients (75.9%). Age (P = 0.02), CRP (P = 0.03), beta‐2 microglobulin (P = 0.001) and left ventricular hypertrophy (P = 0.01) were independently related with CA‐IMT at baseline. Age (P = 0.003) and CRP (P = 0.04) were the independent variables related with CA‐IMT, measured at 12 months. ΔCA‐IMT correlated positively with age (r = 0.31, P < 0.05). Age and sex were independent predictors of ΔCA‐IMT (R2 for the model 0.56).
Conclusion: In addition to age and male sex, non‐specific inflammation may have a possible role in the progression of atherosclerosis in HD patients without significant comorbidities.</description><subject>Adult</subject><subject>Age Distribution</subject><subject>atherosclerosis</subject><subject>Atherosclerosis - diagnostic imaging</subject><subject>Atherosclerosis - epidemiology</subject><subject>C-reactive protein</subject><subject>C-Reactive Protein - metabolism</subject><subject>Carotid Arteries - diagnostic imaging</subject><subject>carotid artery intima-media thickness</subject><subject>Comorbidity</subject><subject>Disease Progression</subject><subject>Female</subject><subject>haemodialysis</subject><subject>Humans</subject><subject>inflammation</subject><subject>Kidney Failure, Chronic - epidemiology</subject><subject>Kidney Failure, Chronic - therapy</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Prospective Studies</subject><subject>Renal Dialysis - statistics & numerical data</subject><subject>Risk Factors</subject><subject>Sex Distribution</subject><subject>Tunica Intima - diagnostic imaging</subject><subject>Tunica Media - diagnostic imaging</subject><subject>Ultrasonography</subject><subject>Vasculitis - epidemiology</subject><issn>1320-5358</issn><issn>1440-1797</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE1P3DAQhi1EVSj0L6CcuCX1RxLHVS-Ir1ZdLRyA9mY5zpj1NokX2yt2_z1Od0WvHcn2aPy8M5oXoYzggqT4sixIWeKccMELinFdpCPKYnOAjt8_DlPOKM4rVjVH6FMIS4wJpzX5iI4IJ0LwpjxGi4u4AO-C7qfbhsyO2ULB4Dqr-u1UWKloYYwhe7Vx4dYxC_Z5tMZqNcZMu8H51nY2MeFrdgUR_GBHNfHOZCvvnj2EYN14ij4Y1Qf4vH9P0OPN9cPl93x2d_vj8mKW6xKXZU5FxQ1mwEzFNMVGENqxWtXQqKqDFG1Fcae44bolGrclqw1lQrTAMSdQsxN0vuubZr-sIUQ52KCh79UIbh1k3VDeNI1IYLMDdVo8eDBy5e2g_FYSLCeX5VJOZsrJTDm5LP-6LDdJerafsW4H6P4J97Ym4NsOeLU9bP-7sZxf36ckyfOd3IYIm3e58n9kzRmv5K_5rcSz-c-n6mkuf7M3Z5adxA</recordid><startdate>200612</startdate><enddate>200612</enddate><creator>ZUMRUTDAL, AYSEGUL</creator><creator>DEMIRCAN, SENOL</creator><creator>SEYDAOGLU, GULSAH</creator><creator>SINGAN, METIN</creator><creator>SEZER, SIREN</creator><creator>OZDEMIR, F NURHAN</creator><creator>HABERAL, MEHMET</creator><general>Blackwell Publishing Asia</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200612</creationdate><title>Atherosclerosis in haemodialysis patients without significant comorbidities: Determinants of progression</title><author>ZUMRUTDAL, AYSEGUL ; DEMIRCAN, SENOL ; SEYDAOGLU, GULSAH ; SINGAN, METIN ; SEZER, SIREN ; OZDEMIR, F NURHAN ; HABERAL, MEHMET</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4044-2957f03e3f53c20f912d36a6e8a5deeeeb520da7f7cb1c0b436f2399be7071e63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adult</topic><topic>Age Distribution</topic><topic>atherosclerosis</topic><topic>Atherosclerosis - diagnostic imaging</topic><topic>Atherosclerosis - epidemiology</topic><topic>C-reactive protein</topic><topic>C-Reactive Protein - metabolism</topic><topic>Carotid Arteries - diagnostic imaging</topic><topic>carotid artery intima-media thickness</topic><topic>Comorbidity</topic><topic>Disease Progression</topic><topic>Female</topic><topic>haemodialysis</topic><topic>Humans</topic><topic>inflammation</topic><topic>Kidney Failure, Chronic - epidemiology</topic><topic>Kidney Failure, Chronic - therapy</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Prospective Studies</topic><topic>Renal Dialysis - statistics & numerical data</topic><topic>Risk Factors</topic><topic>Sex Distribution</topic><topic>Tunica Intima - diagnostic imaging</topic><topic>Tunica Media - diagnostic imaging</topic><topic>Ultrasonography</topic><topic>Vasculitis - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ZUMRUTDAL, AYSEGUL</creatorcontrib><creatorcontrib>DEMIRCAN, SENOL</creatorcontrib><creatorcontrib>SEYDAOGLU, GULSAH</creatorcontrib><creatorcontrib>SINGAN, METIN</creatorcontrib><creatorcontrib>SEZER, SIREN</creatorcontrib><creatorcontrib>OZDEMIR, F NURHAN</creatorcontrib><creatorcontrib>HABERAL, MEHMET</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nephrology (Carlton, Vic.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ZUMRUTDAL, AYSEGUL</au><au>DEMIRCAN, SENOL</au><au>SEYDAOGLU, GULSAH</au><au>SINGAN, METIN</au><au>SEZER, SIREN</au><au>OZDEMIR, F NURHAN</au><au>HABERAL, MEHMET</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Atherosclerosis in haemodialysis patients without significant comorbidities: Determinants of progression</atitle><jtitle>Nephrology (Carlton, Vic.)</jtitle><addtitle>Nephrology (Carlton)</addtitle><date>2006-12</date><risdate>2006</risdate><volume>11</volume><issue>6</issue><spage>489</spage><epage>493</epage><pages>489-493</pages><issn>1320-5358</issn><eissn>1440-1797</eissn><abstract>Aim: The aim of this prospective study was to assess the determinants of the progression of carotid artery intima‐media thickness (CA‐IMT) for 1 year in haemodialysis (HD) patients without significant comorbidities.
Methods: Fifty‐four HD patients younger than 55 years, without diabetes, obesity and any clinical evidence of cardiovascular disease (29 men, 25 women; mean age 33.3 ± 10 years; mean time on HD 49.4 ± 43 months) were included in the 1‐year study. CA‐IMT was assessed at baseline and after 12 months. The difference in IMT between these two points of time was calculated (ΔCA‐IMT). C‐reactive protein (CRP), erythrocyte sedimentation rate (ESR), haematocrit‐corrected ESR, beta‐2 microglobulin, cardiac troponin I, lipid profile, fibrinogen, homocysteine, CaXP product, intact parathyroid hormone, haematocrit, albumin, uric acid levels, anthropometric parameters (age, body mass index), smoking, hypertension and left ventricular hypertrophy were recorded at baseline.
Results: The mean value for CA‐IMT at baseline (0.59 ± 0.05 mm) was significantly lower than that at 12 months (0.64 ± 0.07 mm) (P < 0.001). CA‐IMT had increased in 41 patients (75.9%). Age (P = 0.02), CRP (P = 0.03), beta‐2 microglobulin (P = 0.001) and left ventricular hypertrophy (P = 0.01) were independently related with CA‐IMT at baseline. Age (P = 0.003) and CRP (P = 0.04) were the independent variables related with CA‐IMT, measured at 12 months. ΔCA‐IMT correlated positively with age (r = 0.31, P < 0.05). Age and sex were independent predictors of ΔCA‐IMT (R2 for the model 0.56).
Conclusion: In addition to age and male sex, non‐specific inflammation may have a possible role in the progression of atherosclerosis in HD patients without significant comorbidities.</abstract><cop>Melbourne, Australia</cop><pub>Blackwell Publishing Asia</pub><pmid>17199784</pmid><doi>10.1111/j.1440-1797.2006.00694.x</doi><tpages>5</tpages></addata></record> |
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| subjects | Adult Age Distribution atherosclerosis Atherosclerosis - diagnostic imaging Atherosclerosis - epidemiology C-reactive protein C-Reactive Protein - metabolism Carotid Arteries - diagnostic imaging carotid artery intima-media thickness Comorbidity Disease Progression Female haemodialysis Humans inflammation Kidney Failure, Chronic - epidemiology Kidney Failure, Chronic - therapy Male Middle Aged Prospective Studies Renal Dialysis - statistics & numerical data Risk Factors Sex Distribution Tunica Intima - diagnostic imaging Tunica Media - diagnostic imaging Ultrasonography Vasculitis - epidemiology |
| title | Atherosclerosis in haemodialysis patients without significant comorbidities: Determinants of progression |
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