Comparison of the effects of desflurane and sevoflurane on the expression of platelet surface glycoproteins in unstimulated and adenosine diphosphate-induced platelets in vitro
Abstract Study Objective To compare the effects of one minimum alveolar concentration (MAC) desflurane and sevoflurane on the expression of CD42b (glycoprotein [GP] Ib), CD41 (GPIIb), CD61 (GPIIIa), CD62P (P-selectin), and CD63 in both unstimulated and adenosine diphosphate (ADP)–stimulated platelet...
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| Veröffentlicht in: | Journal of clinical anesthesia 2007-08, Vol.19 (5), p.328-333 |
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| creator | Koroglu, Ahmet, MD Cicek, Muslum, MD Toprak, Huseyin I., MD Karakoc, Yunus, MD Noyan, Funda, MD Ersoy, Ozcan M., MD |
| description | Abstract Study Objective To compare the effects of one minimum alveolar concentration (MAC) desflurane and sevoflurane on the expression of CD42b (glycoprotein [GP] Ib), CD41 (GPIIb), CD61 (GPIIIa), CD62P (P-selectin), and CD63 in both unstimulated and adenosine diphosphate (ADP)–stimulated platelets in vitro. Setting University laboratory. Subjects 15 healthy volunteers. Interventions Platelet-rich plasma was obtained and divided into three groups: platelet-rich plasma exposed to air (group 1); air plus one MAC desflurane (6% vol; group 2), and air plus one MAC sevoflurane (2% vol; group 3), for 40 minutes. Percentage of antigen-positive cells (%+ ) mean channel fluorescence (MCFΣ ), and index of platelet activation for positive platelets (IPA+ ) as expression markers for GPIb, GPIIb, GPIIIa, P-selectin, and CD63, were measured. Measurements and Main Results In unstimulated platelets, expression markers for GPIIb and GPIIIa were significantly lower in groups 2 and 3 than group 1 ( P < 0.001). P-selectin expression markers were significantly higher in group 2 than in group 1 or group 3 ( P < 0.016). CD63 expression markers were significantly lower in group 3 than group 1 ( P < 0.016). In ADP-stimulated platelets, expression markers for all glycoproteins were significantly higher in all groups. Conclusion Neither one MAC desflurane nor sevoflurane showed any significant change in ADP-stimulated platelets compared with the control group. |
| doi_str_mv | 10.1016/j.jclinane.2007.02.002 |
| format | Article |
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Setting University laboratory. Subjects 15 healthy volunteers. Interventions Platelet-rich plasma was obtained and divided into three groups: platelet-rich plasma exposed to air (group 1); air plus one MAC desflurane (6% vol; group 2), and air plus one MAC sevoflurane (2% vol; group 3), for 40 minutes. Percentage of antigen-positive cells (%+ ) mean channel fluorescence (MCFΣ ), and index of platelet activation for positive platelets (IPA+ ) as expression markers for GPIb, GPIIb, GPIIIa, P-selectin, and CD63, were measured. Measurements and Main Results In unstimulated platelets, expression markers for GPIIb and GPIIIa were significantly lower in groups 2 and 3 than group 1 ( P < 0.001). P-selectin expression markers were significantly higher in group 2 than in group 1 or group 3 ( P < 0.016). CD63 expression markers were significantly lower in group 3 than group 1 ( P < 0.016). In ADP-stimulated platelets, expression markers for all glycoproteins were significantly higher in all groups. Conclusion Neither one MAC desflurane nor sevoflurane showed any significant change in ADP-stimulated platelets compared with the control group.</description><identifier>ISSN: 0952-8180</identifier><identifier>EISSN: 1873-4529</identifier><identifier>DOI: 10.1016/j.jclinane.2007.02.002</identifier><identifier>PMID: 17869981</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adenosine ; Adenosine Diphosphate - pharmacology ; Adult ; Anesthesia ; Anesthesia & Perioperative Care ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Anesthetics, Inhalation - pharmacology ; Biological and medical sciences ; Blood platelets ; Blood Platelets - drug effects ; Blood Platelets - metabolism ; Cardiovascular disease ; Cell culture ; Chlorophyll ; Cloning ; Desflurane ; Flow Cytometry - methods ; Humans ; Isoflurane - analogs & derivatives ; Isoflurane - pharmacology ; Medical sciences ; Methyl Ethers - pharmacology ; P-Selectin - blood ; Pain Medicine ; Platelet ; Platelet Activation - drug effects ; Platelet Membrane Glycoproteins - metabolism ; Prospective Studies ; Sevoflurane ; Studies ; Surface glycoproteins ; Volatile anesthetic</subject><ispartof>Journal of clinical anesthesia, 2007-08, Vol.19 (5), p.328-333</ispartof><rights>Elsevier Inc.</rights><rights>2007 Elsevier Inc.</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c479t-73a1ac448b5637655e2a834452a6c5cb007e2c9b3e2ea3733d7fa62e6bf666a83</citedby><cites>FETCH-LOGICAL-c479t-73a1ac448b5637655e2a834452a6c5cb007e2c9b3e2ea3733d7fa62e6bf666a83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0952818007000839$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19120400$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17869981$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Koroglu, Ahmet, MD</creatorcontrib><creatorcontrib>Cicek, Muslum, MD</creatorcontrib><creatorcontrib>Toprak, Huseyin I., MD</creatorcontrib><creatorcontrib>Karakoc, Yunus, MD</creatorcontrib><creatorcontrib>Noyan, Funda, MD</creatorcontrib><creatorcontrib>Ersoy, Ozcan M., MD</creatorcontrib><title>Comparison of the effects of desflurane and sevoflurane on the expression of platelet surface glycoproteins in unstimulated and adenosine diphosphate-induced platelets in vitro</title><title>Journal of clinical anesthesia</title><addtitle>J Clin Anesth</addtitle><description>Abstract Study Objective To compare the effects of one minimum alveolar concentration (MAC) desflurane and sevoflurane on the expression of CD42b (glycoprotein [GP] Ib), CD41 (GPIIb), CD61 (GPIIIa), CD62P (P-selectin), and CD63 in both unstimulated and adenosine diphosphate (ADP)–stimulated platelets in vitro. Setting University laboratory. Subjects 15 healthy volunteers. Interventions Platelet-rich plasma was obtained and divided into three groups: platelet-rich plasma exposed to air (group 1); air plus one MAC desflurane (6% vol; group 2), and air plus one MAC sevoflurane (2% vol; group 3), for 40 minutes. Percentage of antigen-positive cells (%+ ) mean channel fluorescence (MCFΣ ), and index of platelet activation for positive platelets (IPA+ ) as expression markers for GPIb, GPIIb, GPIIIa, P-selectin, and CD63, were measured. Measurements and Main Results In unstimulated platelets, expression markers for GPIIb and GPIIIa were significantly lower in groups 2 and 3 than group 1 ( P < 0.001). P-selectin expression markers were significantly higher in group 2 than in group 1 or group 3 ( P < 0.016). CD63 expression markers were significantly lower in group 3 than group 1 ( P < 0.016). In ADP-stimulated platelets, expression markers for all glycoproteins were significantly higher in all groups. Conclusion Neither one MAC desflurane nor sevoflurane showed any significant change in ADP-stimulated platelets compared with the control group.</description><subject>Adenosine</subject><subject>Adenosine Diphosphate - pharmacology</subject><subject>Adult</subject><subject>Anesthesia</subject><subject>Anesthesia & Perioperative Care</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Anesthetics, Inhalation - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Blood platelets</subject><subject>Blood Platelets - drug effects</subject><subject>Blood Platelets - metabolism</subject><subject>Cardiovascular disease</subject><subject>Cell culture</subject><subject>Chlorophyll</subject><subject>Cloning</subject><subject>Desflurane</subject><subject>Flow Cytometry - methods</subject><subject>Humans</subject><subject>Isoflurane - analogs & derivatives</subject><subject>Isoflurane - pharmacology</subject><subject>Medical sciences</subject><subject>Methyl Ethers - pharmacology</subject><subject>P-Selectin - blood</subject><subject>Pain Medicine</subject><subject>Platelet</subject><subject>Platelet Activation - drug effects</subject><subject>Platelet Membrane Glycoproteins - metabolism</subject><subject>Prospective Studies</subject><subject>Sevoflurane</subject><subject>Studies</subject><subject>Surface glycoproteins</subject><subject>Volatile anesthetic</subject><issn>0952-8180</issn><issn>1873-4529</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFks2u0zAQhSME4pYLr3AVCcEuxXYS29kgUMWfdCUWwNpynQl1Se3gSSr6Vjwik_6o0t2wsix_53hmzmTZHWdLzrh8s11uXe-DDbAUjKklE0vGxKNswbUqi6oWzeNswZpaFJprdpM9Q9wyxuiBP81uuNKyaTRfZH9XcTfY5DGGPHb5uIEcug7ciPO1Bez6KdEvuQ1tjrCPlzvxR_jPkADRn-RDb0foYcxxSp11kP_sDy4OKY7gA-Y-5FPA0e-mmWuPnraFENGTY-uHTcRhQ0-FD-3kiLgYHrV7P6b4PHvS2R7hxfm8zX58_PB99bm4__rpy-r9feEq1YyFKi23rqr0upalknUNwuqyov6tdLVb08xAuGZdggBbqrJsVWelALnupJSE3mavT75U_e8JcDQ7jw76npqPExqpBQ1RcwJfPgC3cUqBajOclVWjtFaCKHmiXIqICTozJL-z6UCQmRM1W3NJ1MyJGiYMJUrCu7P9tN5Be5WdIyTg1Rmw6GzfUTrO45VruGAVY8S9O3FAU9t7SAadh0BT9onyNm30_6_l7QOLmfL06y84AF77NkgC823ev3n9mKLV02VT_gO1yNue</recordid><startdate>20070801</startdate><enddate>20070801</enddate><creator>Koroglu, Ahmet, MD</creator><creator>Cicek, Muslum, MD</creator><creator>Toprak, Huseyin I., MD</creator><creator>Karakoc, Yunus, MD</creator><creator>Noyan, Funda, MD</creator><creator>Ersoy, Ozcan M., MD</creator><general>Elsevier Inc</general><general>Elsevier Science</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20070801</creationdate><title>Comparison of the effects of desflurane and sevoflurane on the expression of platelet surface glycoproteins in unstimulated and adenosine diphosphate-induced platelets in vitro</title><author>Koroglu, Ahmet, MD ; Cicek, Muslum, MD ; Toprak, Huseyin I., MD ; Karakoc, Yunus, MD ; Noyan, Funda, MD ; Ersoy, Ozcan M., MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c479t-73a1ac448b5637655e2a834452a6c5cb007e2c9b3e2ea3733d7fa62e6bf666a83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adenosine</topic><topic>Adenosine Diphosphate - pharmacology</topic><topic>Adult</topic><topic>Anesthesia</topic><topic>Anesthesia & Perioperative Care</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Anesthetics, Inhalation - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Blood platelets</topic><topic>Blood Platelets - drug effects</topic><topic>Blood Platelets - metabolism</topic><topic>Cardiovascular disease</topic><topic>Cell culture</topic><topic>Chlorophyll</topic><topic>Cloning</topic><topic>Desflurane</topic><topic>Flow Cytometry - methods</topic><topic>Humans</topic><topic>Isoflurane - analogs & derivatives</topic><topic>Isoflurane - pharmacology</topic><topic>Medical sciences</topic><topic>Methyl Ethers - pharmacology</topic><topic>P-Selectin - blood</topic><topic>Pain Medicine</topic><topic>Platelet</topic><topic>Platelet Activation - drug effects</topic><topic>Platelet Membrane Glycoproteins - metabolism</topic><topic>Prospective Studies</topic><topic>Sevoflurane</topic><topic>Studies</topic><topic>Surface glycoproteins</topic><topic>Volatile anesthetic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Koroglu, Ahmet, MD</creatorcontrib><creatorcontrib>Cicek, Muslum, MD</creatorcontrib><creatorcontrib>Toprak, Huseyin I., MD</creatorcontrib><creatorcontrib>Karakoc, Yunus, MD</creatorcontrib><creatorcontrib>Noyan, Funda, MD</creatorcontrib><creatorcontrib>Ersoy, Ozcan M., MD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of clinical anesthesia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Koroglu, Ahmet, MD</au><au>Cicek, Muslum, MD</au><au>Toprak, Huseyin I., MD</au><au>Karakoc, Yunus, MD</au><au>Noyan, Funda, MD</au><au>Ersoy, Ozcan M., MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of the effects of desflurane and sevoflurane on the expression of platelet surface glycoproteins in unstimulated and adenosine diphosphate-induced platelets in vitro</atitle><jtitle>Journal of clinical anesthesia</jtitle><addtitle>J Clin Anesth</addtitle><date>2007-08-01</date><risdate>2007</risdate><volume>19</volume><issue>5</issue><spage>328</spage><epage>333</epage><pages>328-333</pages><issn>0952-8180</issn><eissn>1873-4529</eissn><abstract>Abstract Study Objective To compare the effects of one minimum alveolar concentration (MAC) desflurane and sevoflurane on the expression of CD42b (glycoprotein [GP] Ib), CD41 (GPIIb), CD61 (GPIIIa), CD62P (P-selectin), and CD63 in both unstimulated and adenosine diphosphate (ADP)–stimulated platelets in vitro. Setting University laboratory. Subjects 15 healthy volunteers. Interventions Platelet-rich plasma was obtained and divided into three groups: platelet-rich plasma exposed to air (group 1); air plus one MAC desflurane (6% vol; group 2), and air plus one MAC sevoflurane (2% vol; group 3), for 40 minutes. Percentage of antigen-positive cells (%+ ) mean channel fluorescence (MCFΣ ), and index of platelet activation for positive platelets (IPA+ ) as expression markers for GPIb, GPIIb, GPIIIa, P-selectin, and CD63, were measured. Measurements and Main Results In unstimulated platelets, expression markers for GPIIb and GPIIIa were significantly lower in groups 2 and 3 than group 1 ( P < 0.001). P-selectin expression markers were significantly higher in group 2 than in group 1 or group 3 ( P < 0.016). CD63 expression markers were significantly lower in group 3 than group 1 ( P < 0.016). In ADP-stimulated platelets, expression markers for all glycoproteins were significantly higher in all groups. Conclusion Neither one MAC desflurane nor sevoflurane showed any significant change in ADP-stimulated platelets compared with the control group.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>17869981</pmid><doi>10.1016/j.jclinane.2007.02.002</doi><tpages>6</tpages></addata></record> |
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| ispartof | Journal of clinical anesthesia, 2007-08, Vol.19 (5), p.328-333 |
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| subjects | Adenosine Adenosine Diphosphate - pharmacology Adult Anesthesia Anesthesia & Perioperative Care Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Anesthetics, Inhalation - pharmacology Biological and medical sciences Blood platelets Blood Platelets - drug effects Blood Platelets - metabolism Cardiovascular disease Cell culture Chlorophyll Cloning Desflurane Flow Cytometry - methods Humans Isoflurane - analogs & derivatives Isoflurane - pharmacology Medical sciences Methyl Ethers - pharmacology P-Selectin - blood Pain Medicine Platelet Platelet Activation - drug effects Platelet Membrane Glycoproteins - metabolism Prospective Studies Sevoflurane Studies Surface glycoproteins Volatile anesthetic |
| title | Comparison of the effects of desflurane and sevoflurane on the expression of platelet surface glycoproteins in unstimulated and adenosine diphosphate-induced platelets in vitro |
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