Interleukin-10 inhibits RANKL-mediated expression of NFATc1 in part via suppression of c-Fos and c-Jun in RAW264.7 cells and mouse bone marrow cells

Abstract Interleukin-10 (IL-10), an anti-inflammatory cytokine, has been shown to inhibit osteoclast formation and bone resorption in rat and mouse systems. However, the precise intracellular mechanism(s) of this action remains unclear. The aim of this study was to clarify the role of IL-10 in the r...

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Veröffentlicht in:	Bone (New York, N.Y.) N.Y.), 2007-10, Vol.41 (4), p.592-602
Hauptverfasser:	Mohamed, Saad Gad-Kamel, Sugiyama, Eiji, Shinoda, Kouichiro, Taki, Hirofumi, Hounoki, Hiroyuki, Abdel-Aziz, Hekmat Osman, Maruyama, Muneharu, Kobayashi, Masashi, Ogawa, Hirofumi, Miyahara, Tatsuro
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Bone Marrow Cells - cytology Bone Marrow Cells - drug effects Bone Marrow Cells - metabolism c-Fos c-Jun Cell Differentiation - drug effects Cell Line Fundamental and applied biological sciences. Psychology Humans Interleukin-10 Interleukin-10 - pharmacology Mice NF-kappa B p50 Subunit - metabolism NFATC Transcription Factors - genetics NFATC Transcription Factors - metabolism NFATc1 Orthopedics Osteoclastogenesis Osteoclasts - cytology Osteoclasts - drug effects Osteoclasts - metabolism Phosphorylation Proto-Oncogene Proteins c-fos - genetics Proto-Oncogene Proteins c-fos - metabolism Proto-Oncogene Proteins c-jun - metabolism RANK Ligand - pharmacology RANKL RAW264.7 cells Receptors, Interleukin-10 - metabolism RNA, Messenger - genetics Transcription Factor AP-1 - metabolism Vertebrates: anatomy and physiology, studies on body, several organs or systems
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