TRAIL expression up-regulated by interferon-gamma via phosphorylation of STAT1 induces myeloma cell death
Although the cellular and molecular biological effects of interferon (IFN)-alpha have been well-investigated, the effects of IFN-gamma are less understood. Eleven human myeloma cell lines with various myeloma-specific chromosomal translocations and overexpression of oncogenes were cultured with 1000...
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| Veröffentlicht in: | Anticancer research 2006-11, Vol.26 (6B), p.4115-4124 |
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| container_title | Anticancer research |
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| creator | Miura, Yoshie Tsujioka, Takayuki Nishimura, Yasumitsu Sakaguchi, Haruko Maeda, Megumi Hayashi, Hiroaki Dong, Maolong Hyodoh, Fuminori Yata, Ken-Ichiro Wada, Hideho Sugihara, Takashi Otsuki, Takemi |
| description | Although the cellular and molecular biological effects of interferon (IFN)-alpha have been well-investigated, the effects of IFN-gamma are less understood.
Eleven human myeloma cell lines with various myeloma-specific chromosomal translocations and overexpression of oncogenes were cultured with 1000 U/ml of IFN-gamma. In the KMS-20 cells, which showed growth inhibition due to IFN-gamma, trail expression, status of the Janus kinase (JAK)/STAT pathway were analyzed.
KMS-20 cells showed marked up-regulation of trail, activation of STAT1 and TRAIL hyperproduction induced by IFN-gamma.
The effects of IFN-gamma on growth inhibition of KMS-20 cells were characterized by activation of the JAK/STAT signalling pathway, particularly STAT1 phosphorylation, enhanced secretion of TRAIL, and auto/paracrine usage of secreted TRAIL to induce apoptotic cell death. From these results, IFN-gamma may be considered one of the drugs to be used in future multidrug chemotherapeutic regimens for myeloma patients. |
| format | Article |
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Eleven human myeloma cell lines with various myeloma-specific chromosomal translocations and overexpression of oncogenes were cultured with 1000 U/ml of IFN-gamma. In the KMS-20 cells, which showed growth inhibition due to IFN-gamma, trail expression, status of the Janus kinase (JAK)/STAT pathway were analyzed.
KMS-20 cells showed marked up-regulation of trail, activation of STAT1 and TRAIL hyperproduction induced by IFN-gamma.
The effects of IFN-gamma on growth inhibition of KMS-20 cells were characterized by activation of the JAK/STAT signalling pathway, particularly STAT1 phosphorylation, enhanced secretion of TRAIL, and auto/paracrine usage of secreted TRAIL to induce apoptotic cell death. From these results, IFN-gamma may be considered one of the drugs to be used in future multidrug chemotherapeutic regimens for myeloma patients.</description><identifier>ISSN: 0250-7005</identifier><identifier>PMID: 17201122</identifier><language>eng</language><publisher>Greece</publisher><subject>Base Sequence ; Cell Division - drug effects ; Cell Line, Tumor ; DNA Primers ; Gene Expression Regulation, Neoplastic - drug effects ; Humans ; Interferon-gamma - pharmacology ; Multiple Myeloma - metabolism ; Multiple Myeloma - pathology ; Phosphorylation ; STAT1 Transcription Factor - metabolism ; TNF-Related Apoptosis-Inducing Ligand - genetics ; TNF-Related Apoptosis-Inducing Ligand - metabolism ; Tyrphostins - pharmacology ; Up-Regulation - physiology</subject><ispartof>Anticancer research, 2006-11, Vol.26 (6B), p.4115-4124</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17201122$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Miura, Yoshie</creatorcontrib><creatorcontrib>Tsujioka, Takayuki</creatorcontrib><creatorcontrib>Nishimura, Yasumitsu</creatorcontrib><creatorcontrib>Sakaguchi, Haruko</creatorcontrib><creatorcontrib>Maeda, Megumi</creatorcontrib><creatorcontrib>Hayashi, Hiroaki</creatorcontrib><creatorcontrib>Dong, Maolong</creatorcontrib><creatorcontrib>Hyodoh, Fuminori</creatorcontrib><creatorcontrib>Yata, Ken-Ichiro</creatorcontrib><creatorcontrib>Wada, Hideho</creatorcontrib><creatorcontrib>Sugihara, Takashi</creatorcontrib><creatorcontrib>Otsuki, Takemi</creatorcontrib><title>TRAIL expression up-regulated by interferon-gamma via phosphorylation of STAT1 induces myeloma cell death</title><title>Anticancer research</title><addtitle>Anticancer Res</addtitle><description>Although the cellular and molecular biological effects of interferon (IFN)-alpha have been well-investigated, the effects of IFN-gamma are less understood.
Eleven human myeloma cell lines with various myeloma-specific chromosomal translocations and overexpression of oncogenes were cultured with 1000 U/ml of IFN-gamma. In the KMS-20 cells, which showed growth inhibition due to IFN-gamma, trail expression, status of the Janus kinase (JAK)/STAT pathway were analyzed.
KMS-20 cells showed marked up-regulation of trail, activation of STAT1 and TRAIL hyperproduction induced by IFN-gamma.
The effects of IFN-gamma on growth inhibition of KMS-20 cells were characterized by activation of the JAK/STAT signalling pathway, particularly STAT1 phosphorylation, enhanced secretion of TRAIL, and auto/paracrine usage of secreted TRAIL to induce apoptotic cell death. From these results, IFN-gamma may be considered one of the drugs to be used in future multidrug chemotherapeutic regimens for myeloma patients.</description><subject>Base Sequence</subject><subject>Cell Division - drug effects</subject><subject>Cell Line, Tumor</subject><subject>DNA Primers</subject><subject>Gene Expression Regulation, Neoplastic - drug effects</subject><subject>Humans</subject><subject>Interferon-gamma - pharmacology</subject><subject>Multiple Myeloma - metabolism</subject><subject>Multiple Myeloma - pathology</subject><subject>Phosphorylation</subject><subject>STAT1 Transcription Factor - metabolism</subject><subject>TNF-Related Apoptosis-Inducing Ligand - genetics</subject><subject>TNF-Related Apoptosis-Inducing Ligand - metabolism</subject><subject>Tyrphostins - pharmacology</subject><subject>Up-Regulation - physiology</subject><issn>0250-7005</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo10E1PhDAQBuAeNO66-hdMT95I2ikt9Eg2fmxCYqJ4Jt0y7GKAYgtG_r1sdj1M5vK8kzdzRdYMJIsSxuSK3IbwxZhSOhU3ZMUTYJwDrElTvGe7nOLv4DGExvV0GiKPh6k1I1Z0P9OmH9HX6F0fHUzXGfrTGDocXVjGzws7hVxNP4qs4IuuJouBdjO2bsEW25ZWaMbjHbmuTRvw_rI35PP5qdi-Rvnby26b5dEATI8RF0s3YbSyUqIG4KhAG6VjzUQqOShlIdayTqGWOjZaCpvYtBaxEGDQotiQx_PdwbvvCcNYdk041TA9uimUKoUkUZIt8OECp32HVTn4pjN-Lv-fI_4AW_Ne-g</recordid><startdate>200611</startdate><enddate>200611</enddate><creator>Miura, Yoshie</creator><creator>Tsujioka, Takayuki</creator><creator>Nishimura, Yasumitsu</creator><creator>Sakaguchi, Haruko</creator><creator>Maeda, Megumi</creator><creator>Hayashi, Hiroaki</creator><creator>Dong, Maolong</creator><creator>Hyodoh, Fuminori</creator><creator>Yata, Ken-Ichiro</creator><creator>Wada, Hideho</creator><creator>Sugihara, Takashi</creator><creator>Otsuki, Takemi</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200611</creationdate><title>TRAIL expression up-regulated by interferon-gamma via phosphorylation of STAT1 induces myeloma cell death</title><author>Miura, Yoshie ; Tsujioka, Takayuki ; Nishimura, Yasumitsu ; Sakaguchi, Haruko ; Maeda, Megumi ; Hayashi, Hiroaki ; Dong, Maolong ; Hyodoh, Fuminori ; Yata, Ken-Ichiro ; Wada, Hideho ; Sugihara, Takashi ; Otsuki, Takemi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p209t-137203a96c55e9221e629a694903851266c2495f82f594a953c7c8f34332aece3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Base Sequence</topic><topic>Cell Division - drug effects</topic><topic>Cell Line, Tumor</topic><topic>DNA Primers</topic><topic>Gene Expression Regulation, Neoplastic - drug effects</topic><topic>Humans</topic><topic>Interferon-gamma - pharmacology</topic><topic>Multiple Myeloma - metabolism</topic><topic>Multiple Myeloma - pathology</topic><topic>Phosphorylation</topic><topic>STAT1 Transcription Factor - metabolism</topic><topic>TNF-Related Apoptosis-Inducing Ligand - genetics</topic><topic>TNF-Related Apoptosis-Inducing Ligand - metabolism</topic><topic>Tyrphostins - pharmacology</topic><topic>Up-Regulation - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Miura, Yoshie</creatorcontrib><creatorcontrib>Tsujioka, Takayuki</creatorcontrib><creatorcontrib>Nishimura, Yasumitsu</creatorcontrib><creatorcontrib>Sakaguchi, Haruko</creatorcontrib><creatorcontrib>Maeda, Megumi</creatorcontrib><creatorcontrib>Hayashi, Hiroaki</creatorcontrib><creatorcontrib>Dong, Maolong</creatorcontrib><creatorcontrib>Hyodoh, Fuminori</creatorcontrib><creatorcontrib>Yata, Ken-Ichiro</creatorcontrib><creatorcontrib>Wada, Hideho</creatorcontrib><creatorcontrib>Sugihara, Takashi</creatorcontrib><creatorcontrib>Otsuki, Takemi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Anticancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Miura, Yoshie</au><au>Tsujioka, Takayuki</au><au>Nishimura, Yasumitsu</au><au>Sakaguchi, Haruko</au><au>Maeda, Megumi</au><au>Hayashi, Hiroaki</au><au>Dong, Maolong</au><au>Hyodoh, Fuminori</au><au>Yata, Ken-Ichiro</au><au>Wada, Hideho</au><au>Sugihara, Takashi</au><au>Otsuki, Takemi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>TRAIL expression up-regulated by interferon-gamma via phosphorylation of STAT1 induces myeloma cell death</atitle><jtitle>Anticancer research</jtitle><addtitle>Anticancer Res</addtitle><date>2006-11</date><risdate>2006</risdate><volume>26</volume><issue>6B</issue><spage>4115</spage><epage>4124</epage><pages>4115-4124</pages><issn>0250-7005</issn><abstract>Although the cellular and molecular biological effects of interferon (IFN)-alpha have been well-investigated, the effects of IFN-gamma are less understood.
Eleven human myeloma cell lines with various myeloma-specific chromosomal translocations and overexpression of oncogenes were cultured with 1000 U/ml of IFN-gamma. In the KMS-20 cells, which showed growth inhibition due to IFN-gamma, trail expression, status of the Janus kinase (JAK)/STAT pathway were analyzed.
KMS-20 cells showed marked up-regulation of trail, activation of STAT1 and TRAIL hyperproduction induced by IFN-gamma.
The effects of IFN-gamma on growth inhibition of KMS-20 cells were characterized by activation of the JAK/STAT signalling pathway, particularly STAT1 phosphorylation, enhanced secretion of TRAIL, and auto/paracrine usage of secreted TRAIL to induce apoptotic cell death. From these results, IFN-gamma may be considered one of the drugs to be used in future multidrug chemotherapeutic regimens for myeloma patients.</abstract><cop>Greece</cop><pmid>17201122</pmid><tpages>10</tpages></addata></record> |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Base Sequence Cell Division - drug effects Cell Line, Tumor DNA Primers Gene Expression Regulation, Neoplastic - drug effects Humans Interferon-gamma - pharmacology Multiple Myeloma - metabolism Multiple Myeloma - pathology Phosphorylation STAT1 Transcription Factor - metabolism TNF-Related Apoptosis-Inducing Ligand - genetics TNF-Related Apoptosis-Inducing Ligand - metabolism Tyrphostins - pharmacology Up-Regulation - physiology |
| title | TRAIL expression up-regulated by interferon-gamma via phosphorylation of STAT1 induces myeloma cell death |
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