Synthesis of novel HIV protease inhibitors (PI) with activity against PI-resistant virus

HIV protease inhibitors with modifications on the P3 position have been designed and synthesized. These compounds exhibit excellent antiviral activity against both the wild type enzyme and PI-resistant clinical viral isolates. A series of HIV protease inhibitors with modifications on the P3 position...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2007-10, Vol.17 (19), p.5432-5436
Hauptverfasser:	Raghavan, Subharekha, Lu, Zhijian, Beeson, Teresa, Chapman, Kevin T., Schleif, William A., Olsen, David B., Stahlhut, Mark, Rutkowski, Carrie A., Gabryelski, Lori, Emini, Emilio, Tata, James R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Biological and medical sciences Cell Line Drug Resistance, Viral HIV HIV Infections - drug therapy HIV Infections - virology HIV Protease Inhibitors - chemical synthesis HIV Protease Inhibitors - pharmacology HIV-1 - drug effects Humans Indicators and Reagents Indinavir - chemical synthesis Indinavir - pharmacology Medical sciences Pharmacology. Drug treatments Protease inhibitors Structure-Activity Relationship
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	HIV protease inhibitors with modifications on the P3 position have been designed and synthesized. These compounds exhibit excellent antiviral activity against both the wild type enzyme and PI-resistant clinical viral isolates. A series of HIV protease inhibitors with modifications on the P3 position have been designed and synthesized. These compounds exhibit excellent antiviral activity against both the wild type enzyme and PI-resistant clinical viral isolates. The synthesis and biological activity of the compounds are described.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2007.07.040