Incidence of ventricular tachyarrhythmias during permanent pacemaker therapy in low-risk patients results from the German multicentre EVENTS study
Aims Current studies found an incidence of 12–31% ventricular tachyarrhythmias and sudden cardiac death during cardiac pacing months or even years after pacemaker insertion. MADIT12 and MUSTT13 demonstrated that patients with poor LV function after Myocardial infarction (MI) showing non-sustained ve...
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| Veröffentlicht in: | European heart journal 2007-09, Vol.28 (18), p.2238-2242 |
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| creator | Faber, Thomas S. Gradinger, Robert Treusch, Sven Morkel, Carsten Brachmann, Johannes Bode, Christoph Zehender, Manfred |
| description | Aims Current studies found an incidence of 12–31% ventricular tachyarrhythmias and sudden cardiac death during cardiac pacing months or even years after pacemaker insertion. MADIT12 and MUSTT13 demonstrated that patients with poor LV function after Myocardial infarction (MI) showing non-sustained ventricular tachycardia (nsVT) and inducibility during electrophysiologic testing benefit from an ICD. The present study was dedicated to assess the global incidence of non-sustained ventricular arrhythmias in a general population of pacemaker patients. Special regard was on patients with a potential ICD indication, e.g. those matching the MADIT/MUSTT criteria. Methods and results Two hundred and thirty-one patients (72 ± 11 years; 134 men) with an indication for dual chamber pacing entered the study. In all patients pacemaker systems capable of automatic storing of intracardiac electrocardiograms were implanted (Pulsar®, Discovery®, Guidant). Follow-up time was 15 months after inclusion. In 54 (25.7%) of 210 patients with at least one follow-up, episodes of nsVT were documented by stored electrocardiograms (up to >30 beats, >200 b.p.m.). Multiple—up to nine—episodes of ventricular tachycardia were retrieved in 31 of these patients. Three out of 14 patients with an LVEF |
| doi_str_mv | 10.1093/eurheartj/ehm242 |
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MADIT12 and MUSTT13 demonstrated that patients with poor LV function after Myocardial infarction (MI) showing non-sustained ventricular tachycardia (nsVT) and inducibility during electrophysiologic testing benefit from an ICD. The present study was dedicated to assess the global incidence of non-sustained ventricular arrhythmias in a general population of pacemaker patients. Special regard was on patients with a potential ICD indication, e.g. those matching the MADIT/MUSTT criteria. Methods and results Two hundred and thirty-one patients (72 ± 11 years; 134 men) with an indication for dual chamber pacing entered the study. In all patients pacemaker systems capable of automatic storing of intracardiac electrocardiograms were implanted (Pulsar®, Discovery®, Guidant). Follow-up time was 15 months after inclusion. In 54 (25.7%) of 210 patients with at least one follow-up, episodes of nsVT were documented by stored electrocardiograms (up to >30 beats, >200 b.p.m.). Multiple—up to nine—episodes of ventricular tachycardia were retrieved in 31 of these patients. Three out of 14 patients with an LVEF <40% after MI presented nsVT during the follow-up. One of these patients received an ICD. Conclusion A significant number of pacemaker patients present with ventricular tachycardia. Intracardiac electrocardiograms and alert functions from pacemakers may enhance physicians' awareness of the patient's intrinsic arrhythmic profile and help uncover underlying mechanisms of arrhythmias by storing the initiation of the arrhythmia.</description><identifier>ISSN: 0195-668X</identifier><identifier>EISSN: 1522-9645</identifier><identifier>DOI: 10.1093/eurheartj/ehm242</identifier><identifier>PMID: 17636308</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Aged ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Cardiac dysrhythmias ; Cardiac Pacing, Artificial ; Cardiology. Vascular system ; Coronary Disease - complications ; Death, Sudden, Cardiac - etiology ; Electrocardiography ; Emergency and intensive care: neonates and children. Prematurity. Sudden death ; Female ; Germany ; Heart ; Humans ; Intensive care medicine ; Male ; Medical sciences ; Myocardial Infarction - complications ; Pacemaker ; Pacemaker, Artificial ; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) ; Risk Factors ; Stroke Volume ; Sudden death ; Tachycardia, Ventricular - etiology ; Ventricular arrhythmia ; Ventricular Dysfunction, Left - complications</subject><ispartof>European heart journal, 2007-09, Vol.28 (18), p.2238-2242</ispartof><rights>The European Society of Cardiology 2007. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org 2007</rights><rights>2007 INIST-CNRS</rights><rights>The European Society of Cardiology 2007. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c536t-cbf46aea482f7da8d1a6253be4f40687e1b3c1b82e2884e3bff33d4e05e13f843</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1583,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19075805$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17636308$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Faber, Thomas S.</creatorcontrib><creatorcontrib>Gradinger, Robert</creatorcontrib><creatorcontrib>Treusch, Sven</creatorcontrib><creatorcontrib>Morkel, Carsten</creatorcontrib><creatorcontrib>Brachmann, Johannes</creatorcontrib><creatorcontrib>Bode, Christoph</creatorcontrib><creatorcontrib>Zehender, Manfred</creatorcontrib><creatorcontrib>EVENTS Investigators</creatorcontrib><creatorcontrib>for the EVENTS Investigators</creatorcontrib><title>Incidence of ventricular tachyarrhythmias during permanent pacemaker therapy in low-risk patients results from the German multicentre EVENTS study</title><title>European heart journal</title><addtitle>Eur Heart J</addtitle><description>Aims Current studies found an incidence of 12–31% ventricular tachyarrhythmias and sudden cardiac death during cardiac pacing months or even years after pacemaker insertion. MADIT12 and MUSTT13 demonstrated that patients with poor LV function after Myocardial infarction (MI) showing non-sustained ventricular tachycardia (nsVT) and inducibility during electrophysiologic testing benefit from an ICD. The present study was dedicated to assess the global incidence of non-sustained ventricular arrhythmias in a general population of pacemaker patients. Special regard was on patients with a potential ICD indication, e.g. those matching the MADIT/MUSTT criteria. Methods and results Two hundred and thirty-one patients (72 ± 11 years; 134 men) with an indication for dual chamber pacing entered the study. In all patients pacemaker systems capable of automatic storing of intracardiac electrocardiograms were implanted (Pulsar®, Discovery®, Guidant). Follow-up time was 15 months after inclusion. In 54 (25.7%) of 210 patients with at least one follow-up, episodes of nsVT were documented by stored electrocardiograms (up to >30 beats, >200 b.p.m.). Multiple—up to nine—episodes of ventricular tachycardia were retrieved in 31 of these patients. Three out of 14 patients with an LVEF <40% after MI presented nsVT during the follow-up. One of these patients received an ICD. Conclusion A significant number of pacemaker patients present with ventricular tachycardia. Intracardiac electrocardiograms and alert functions from pacemakers may enhance physicians' awareness of the patient's intrinsic arrhythmic profile and help uncover underlying mechanisms of arrhythmias by storing the initiation of the arrhythmia.</description><subject>Aged</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Cardiac dysrhythmias</subject><subject>Cardiac Pacing, Artificial</subject><subject>Cardiology. Vascular system</subject><subject>Coronary Disease - complications</subject><subject>Death, Sudden, Cardiac - etiology</subject><subject>Electrocardiography</subject><subject>Emergency and intensive care: neonates and children. Prematurity. Sudden death</subject><subject>Female</subject><subject>Germany</subject><subject>Heart</subject><subject>Humans</subject><subject>Intensive care medicine</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Myocardial Infarction - complications</subject><subject>Pacemaker</subject><subject>Pacemaker, Artificial</subject><subject>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</subject><subject>Risk Factors</subject><subject>Stroke Volume</subject><subject>Sudden death</subject><subject>Tachycardia, Ventricular - etiology</subject><subject>Ventricular arrhythmia</subject><subject>Ventricular Dysfunction, Left - complications</subject><issn>0195-668X</issn><issn>1522-9645</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0Utv1DAQB_AIgei2cOeELCR6QaF-xI5zRNXShxZQ1QVVXCzHGRPv5oWdAPkafGK87KqVOHEayf7NjK1_krwg-C3BBTuDydeg_bg5g7qlGX2ULAinNC1Exh8nC0wKngoh746S4xA2GGMpiHiaHJFcMMGwXCS_rzrjKugMoN6iH9CN3pmp0R6N2tSz9r6ex7p1OqBq8q77hgbwre4iRIM20OotRFuD18OMXIea_mfqXdjG29FFFZCHMDWxWt-3O4ku_k5AbTx1ZrcR0PLL8uP6FoVxquZnyROrmwDPD_Uk-fx-uT6_TFefLq7O361Sw5kYU1PaTGjQmaQ2r7SsiBaUsxIym2EhcyAlM6SUFKiUGbDSWsaqDDAHwqzM2Elyup87-P77BGFUrQsGmib-rp-CEpLmghAR4at_4KaffBffpijhHHPCi4jwHhnfh-DBqsG7VvtZEax2Yan7sNQ-rNjy8jB3KluoHhoO6UTw-gB0MLqxXsewwoMrcM4l5tG92bt-Gv5nbbrXLozw695rv1UiZzlXl3df1fX6ZiU_3Nyqa_YHpuPC4Q</recordid><startdate>20070901</startdate><enddate>20070901</enddate><creator>Faber, Thomas S.</creator><creator>Gradinger, Robert</creator><creator>Treusch, Sven</creator><creator>Morkel, Carsten</creator><creator>Brachmann, Johannes</creator><creator>Bode, Christoph</creator><creator>Zehender, Manfred</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20070901</creationdate><title>Incidence of ventricular tachyarrhythmias during permanent pacemaker therapy in low-risk patients results from the German multicentre EVENTS study</title><author>Faber, Thomas S. ; Gradinger, Robert ; Treusch, Sven ; Morkel, Carsten ; Brachmann, Johannes ; Bode, Christoph ; Zehender, Manfred</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c536t-cbf46aea482f7da8d1a6253be4f40687e1b3c1b82e2884e3bff33d4e05e13f843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Aged</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Cardiac dysrhythmias</topic><topic>Cardiac Pacing, Artificial</topic><topic>Cardiology. Vascular system</topic><topic>Coronary Disease - complications</topic><topic>Death, Sudden, Cardiac - etiology</topic><topic>Electrocardiography</topic><topic>Emergency and intensive care: neonates and children. Prematurity. Sudden death</topic><topic>Female</topic><topic>Germany</topic><topic>Heart</topic><topic>Humans</topic><topic>Intensive care medicine</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Myocardial Infarction - complications</topic><topic>Pacemaker</topic><topic>Pacemaker, Artificial</topic><topic>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</topic><topic>Risk Factors</topic><topic>Stroke Volume</topic><topic>Sudden death</topic><topic>Tachycardia, Ventricular - etiology</topic><topic>Ventricular arrhythmia</topic><topic>Ventricular Dysfunction, Left - complications</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Faber, Thomas S.</creatorcontrib><creatorcontrib>Gradinger, Robert</creatorcontrib><creatorcontrib>Treusch, Sven</creatorcontrib><creatorcontrib>Morkel, Carsten</creatorcontrib><creatorcontrib>Brachmann, Johannes</creatorcontrib><creatorcontrib>Bode, Christoph</creatorcontrib><creatorcontrib>Zehender, Manfred</creatorcontrib><creatorcontrib>EVENTS Investigators</creatorcontrib><creatorcontrib>for the EVENTS Investigators</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>European heart journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Faber, Thomas S.</au><au>Gradinger, Robert</au><au>Treusch, Sven</au><au>Morkel, Carsten</au><au>Brachmann, Johannes</au><au>Bode, Christoph</au><au>Zehender, Manfred</au><aucorp>EVENTS Investigators</aucorp><aucorp>for the EVENTS Investigators</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Incidence of ventricular tachyarrhythmias during permanent pacemaker therapy in low-risk patients results from the German multicentre EVENTS study</atitle><jtitle>European heart journal</jtitle><addtitle>Eur Heart J</addtitle><date>2007-09-01</date><risdate>2007</risdate><volume>28</volume><issue>18</issue><spage>2238</spage><epage>2242</epage><pages>2238-2242</pages><issn>0195-668X</issn><eissn>1522-9645</eissn><abstract>Aims Current studies found an incidence of 12–31% ventricular tachyarrhythmias and sudden cardiac death during cardiac pacing months or even years after pacemaker insertion. MADIT12 and MUSTT13 demonstrated that patients with poor LV function after Myocardial infarction (MI) showing non-sustained ventricular tachycardia (nsVT) and inducibility during electrophysiologic testing benefit from an ICD. The present study was dedicated to assess the global incidence of non-sustained ventricular arrhythmias in a general population of pacemaker patients. Special regard was on patients with a potential ICD indication, e.g. those matching the MADIT/MUSTT criteria. Methods and results Two hundred and thirty-one patients (72 ± 11 years; 134 men) with an indication for dual chamber pacing entered the study. In all patients pacemaker systems capable of automatic storing of intracardiac electrocardiograms were implanted (Pulsar®, Discovery®, Guidant). Follow-up time was 15 months after inclusion. In 54 (25.7%) of 210 patients with at least one follow-up, episodes of nsVT were documented by stored electrocardiograms (up to >30 beats, >200 b.p.m.). Multiple—up to nine—episodes of ventricular tachycardia were retrieved in 31 of these patients. Three out of 14 patients with an LVEF <40% after MI presented nsVT during the follow-up. One of these patients received an ICD. Conclusion A significant number of pacemaker patients present with ventricular tachycardia. Intracardiac electrocardiograms and alert functions from pacemakers may enhance physicians' awareness of the patient's intrinsic arrhythmic profile and help uncover underlying mechanisms of arrhythmias by storing the initiation of the arrhythmia.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>17636308</pmid><doi>10.1093/eurheartj/ehm242</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Cardiac dysrhythmias Cardiac Pacing, Artificial Cardiology. Vascular system Coronary Disease - complications Death, Sudden, Cardiac - etiology Electrocardiography Emergency and intensive care: neonates and children. Prematurity. Sudden death Female Germany Heart Humans Intensive care medicine Male Medical sciences Myocardial Infarction - complications Pacemaker Pacemaker, Artificial Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Risk Factors Stroke Volume Sudden death Tachycardia, Ventricular - etiology Ventricular arrhythmia Ventricular Dysfunction, Left - complications |
| title | Incidence of ventricular tachyarrhythmias during permanent pacemaker therapy in low-risk patients results from the German multicentre EVENTS study |
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