Serum Hyaluronan Concentration as a Marker of Angiopathy in Patients with Diabetes Mellitus
Accumulation of hyaluronan (HA) around smooth muscle cells in lesions of atherosclerosis in diabetic patients suggests that this protein plays an important role in diabetic angiopathy. The aim of this study was to determine the correlation between serum HA concentrations and diabetic angiopathy. Dia...
Gespeichert in:
| Veröffentlicht in: | Endocrine Journal 2006, Vol.53(6), pp.761-766 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 766 |
|---|---|
| container_issue | 6 |
| container_start_page | 761 |
| container_title | Endocrine Journal |
| container_volume | 53 |
| creator | MINE, Shinichiro OKADA, Yosuke KAWAHARA, Chie TABATA, Takahiro TANAKA, Yoshiya |
| description | Accumulation of hyaluronan (HA) around smooth muscle cells in lesions of atherosclerosis in diabetic patients suggests that this protein plays an important role in diabetic angiopathy. The aim of this study was to determine the correlation between serum HA concentrations and diabetic angiopathy. Diabetic patients treated with or without an oral hypoglycemic agent and/or insulin for at least 1 year were recruited (n = 95). We also included 20 non-diabetic control subjects. We measured serum levels of HA, body mass index (BMI), fasting plasma glucose (FPG), HbA1c, total cholesterol, triglyceride, glycated albumin (GA), high sensitivity CRP (hs-CRP), monocyte chemoattractant protein (MCP)-1 and evaluated diabetes mellitus history, drug use and presence of related complications. Serum HA levels were significantly (P |
| doi_str_mv | 10.1507/endocrj.K05-119 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68275685</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>68275685</sourcerecordid><originalsourceid>FETCH-LOGICAL-c532t-de59aa840c1b7913f862f217a954e90eb3fc4a88526e678ced809b4a69e795263</originalsourceid><addsrcrecordid>eNpFkEFvEzEQRi0EoqFw5oZ84ratvV577WMVCkW0KhL01IM168w2Dhs72F5V-fe4ShQuHsnz5tPMI-QjZxdcsv4Swyq6tLn4wWTDuXlFFlx0uulkx16TBTNcN9pIc0be5bxhTAjZibfkjCujlG77BXn8hWne0ps9THOKAQJdxuAwlATFx0AhU6B3kP5gonGkV-HJxx2U9Z76QH9WpqKZPvuypl88DFgw0zucJl_m_J68GWHK-OFYz8nD1-vfy5vm9v7b9-XVbeOkaEuzQmkAdMccH3rDxahVO7a8ByM7NAwHMboOtJatQtVrhyvNzNCBMtib-inOyedD7i7FvzPmYrc-u7oEBIxzti-XSqVlBS8PoEsx54Sj3SW_hbS3nNkXn_bo01aftvqsE5-O0fOwxdV__iiwAssDsMkFnvAEQCreTXgKlMKqw9Mrfuq6NaSKiH9_AYwA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>68275685</pqid></control><display><type>article</type><title>Serum Hyaluronan Concentration as a Marker of Angiopathy in Patients with Diabetes Mellitus</title><source>J-STAGE Free</source><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>MINE, Shinichiro ; OKADA, Yosuke ; KAWAHARA, Chie ; TABATA, Takahiro ; TANAKA, Yoshiya</creator><creatorcontrib>MINE, Shinichiro ; OKADA, Yosuke ; KAWAHARA, Chie ; TABATA, Takahiro ; TANAKA, Yoshiya</creatorcontrib><description>Accumulation of hyaluronan (HA) around smooth muscle cells in lesions of atherosclerosis in diabetic patients suggests that this protein plays an important role in diabetic angiopathy. The aim of this study was to determine the correlation between serum HA concentrations and diabetic angiopathy. Diabetic patients treated with or without an oral hypoglycemic agent and/or insulin for at least 1 year were recruited (n = 95). We also included 20 non-diabetic control subjects. We measured serum levels of HA, body mass index (BMI), fasting plasma glucose (FPG), HbA1c, total cholesterol, triglyceride, glycated albumin (GA), high sensitivity CRP (hs-CRP), monocyte chemoattractant protein (MCP)-1 and evaluated diabetes mellitus history, drug use and presence of related complications. Serum HA levels were significantly (P<0.05) higher in diabetic patients (83.6 ± 5.6 ng/ml, mean ± SEM) than in normal subjects (41.7 ± 12 ng/ml). In diabetic patients, serum HA concentration significantly correlated with FPG, HbA1c, GA, triglyceride and also significantly correlated with BMI, hs-CRP and MCP-1 and tended to be higher in diabetic patients with complications than in those without such complications. Our data suggest that serum HA level correlates with poor blood glucose control and diabetic angiopathy and that it could be used as a marker of diabetic angiopathy.</description><identifier>ISSN: 0918-8959</identifier><identifier>EISSN: 1348-4540</identifier><identifier>DOI: 10.1507/endocrj.K05-119</identifier><identifier>PMID: 16966827</identifier><language>eng</language><publisher>Japan: The Japan Endocrine Society</publisher><subject>Angiopathy ; Blood Glucose - analysis ; Body Mass Index ; C-Reactive Protein - analysis ; Chemokine CCL2 - blood ; Complication ; Diabetes control ; Diabetes mellitus ; Diabetes Mellitus, Type 2 - blood ; Diabetic Angiopathies - blood ; Glycated Hemoglobin A ; Hemoglobins - analysis ; Humans ; Hyaluronic Acid - blood ; Serum Albumin - analysis ; Serum hyaluronic acid ; Triglycerides - blood</subject><ispartof>Endocrine Journal, 2006, Vol.53(6), pp.761-766</ispartof><rights>The Japan Endocrine Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c532t-de59aa840c1b7913f862f217a954e90eb3fc4a88526e678ced809b4a69e795263</citedby><cites>FETCH-LOGICAL-c532t-de59aa840c1b7913f862f217a954e90eb3fc4a88526e678ced809b4a69e795263</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16966827$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MINE, Shinichiro</creatorcontrib><creatorcontrib>OKADA, Yosuke</creatorcontrib><creatorcontrib>KAWAHARA, Chie</creatorcontrib><creatorcontrib>TABATA, Takahiro</creatorcontrib><creatorcontrib>TANAKA, Yoshiya</creatorcontrib><title>Serum Hyaluronan Concentration as a Marker of Angiopathy in Patients with Diabetes Mellitus</title><title>Endocrine Journal</title><addtitle>Endocr J</addtitle><description>Accumulation of hyaluronan (HA) around smooth muscle cells in lesions of atherosclerosis in diabetic patients suggests that this protein plays an important role in diabetic angiopathy. The aim of this study was to determine the correlation between serum HA concentrations and diabetic angiopathy. Diabetic patients treated with or without an oral hypoglycemic agent and/or insulin for at least 1 year were recruited (n = 95). We also included 20 non-diabetic control subjects. We measured serum levels of HA, body mass index (BMI), fasting plasma glucose (FPG), HbA1c, total cholesterol, triglyceride, glycated albumin (GA), high sensitivity CRP (hs-CRP), monocyte chemoattractant protein (MCP)-1 and evaluated diabetes mellitus history, drug use and presence of related complications. Serum HA levels were significantly (P<0.05) higher in diabetic patients (83.6 ± 5.6 ng/ml, mean ± SEM) than in normal subjects (41.7 ± 12 ng/ml). In diabetic patients, serum HA concentration significantly correlated with FPG, HbA1c, GA, triglyceride and also significantly correlated with BMI, hs-CRP and MCP-1 and tended to be higher in diabetic patients with complications than in those without such complications. Our data suggest that serum HA level correlates with poor blood glucose control and diabetic angiopathy and that it could be used as a marker of diabetic angiopathy.</description><subject>Angiopathy</subject><subject>Blood Glucose - analysis</subject><subject>Body Mass Index</subject><subject>C-Reactive Protein - analysis</subject><subject>Chemokine CCL2 - blood</subject><subject>Complication</subject><subject>Diabetes control</subject><subject>Diabetes mellitus</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Diabetic Angiopathies - blood</subject><subject>Glycated Hemoglobin A</subject><subject>Hemoglobins - analysis</subject><subject>Humans</subject><subject>Hyaluronic Acid - blood</subject><subject>Serum Albumin - analysis</subject><subject>Serum hyaluronic acid</subject><subject>Triglycerides - blood</subject><issn>0918-8959</issn><issn>1348-4540</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkEFvEzEQRi0EoqFw5oZ84ratvV577WMVCkW0KhL01IM168w2Dhs72F5V-fe4ShQuHsnz5tPMI-QjZxdcsv4Swyq6tLn4wWTDuXlFFlx0uulkx16TBTNcN9pIc0be5bxhTAjZibfkjCujlG77BXn8hWne0ps9THOKAQJdxuAwlATFx0AhU6B3kP5gonGkV-HJxx2U9Z76QH9WpqKZPvuypl88DFgw0zucJl_m_J68GWHK-OFYz8nD1-vfy5vm9v7b9-XVbeOkaEuzQmkAdMccH3rDxahVO7a8ByM7NAwHMboOtJatQtVrhyvNzNCBMtib-inOyedD7i7FvzPmYrc-u7oEBIxzti-XSqVlBS8PoEsx54Sj3SW_hbS3nNkXn_bo01aftvqsE5-O0fOwxdV__iiwAssDsMkFnvAEQCreTXgKlMKqw9Mrfuq6NaSKiH9_AYwA</recordid><startdate>2006</startdate><enddate>2006</enddate><creator>MINE, Shinichiro</creator><creator>OKADA, Yosuke</creator><creator>KAWAHARA, Chie</creator><creator>TABATA, Takahiro</creator><creator>TANAKA, Yoshiya</creator><general>The Japan Endocrine Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2006</creationdate><title>Serum Hyaluronan Concentration as a Marker of Angiopathy in Patients with Diabetes Mellitus</title><author>MINE, Shinichiro ; OKADA, Yosuke ; KAWAHARA, Chie ; TABATA, Takahiro ; TANAKA, Yoshiya</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c532t-de59aa840c1b7913f862f217a954e90eb3fc4a88526e678ced809b4a69e795263</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Angiopathy</topic><topic>Blood Glucose - analysis</topic><topic>Body Mass Index</topic><topic>C-Reactive Protein - analysis</topic><topic>Chemokine CCL2 - blood</topic><topic>Complication</topic><topic>Diabetes control</topic><topic>Diabetes mellitus</topic><topic>Diabetes Mellitus, Type 2 - blood</topic><topic>Diabetic Angiopathies - blood</topic><topic>Glycated Hemoglobin A</topic><topic>Hemoglobins - analysis</topic><topic>Humans</topic><topic>Hyaluronic Acid - blood</topic><topic>Serum Albumin - analysis</topic><topic>Serum hyaluronic acid</topic><topic>Triglycerides - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MINE, Shinichiro</creatorcontrib><creatorcontrib>OKADA, Yosuke</creatorcontrib><creatorcontrib>KAWAHARA, Chie</creatorcontrib><creatorcontrib>TABATA, Takahiro</creatorcontrib><creatorcontrib>TANAKA, Yoshiya</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Endocrine Journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MINE, Shinichiro</au><au>OKADA, Yosuke</au><au>KAWAHARA, Chie</au><au>TABATA, Takahiro</au><au>TANAKA, Yoshiya</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum Hyaluronan Concentration as a Marker of Angiopathy in Patients with Diabetes Mellitus</atitle><jtitle>Endocrine Journal</jtitle><addtitle>Endocr J</addtitle><date>2006</date><risdate>2006</risdate><volume>53</volume><issue>6</issue><spage>761</spage><epage>766</epage><pages>761-766</pages><issn>0918-8959</issn><eissn>1348-4540</eissn><abstract>Accumulation of hyaluronan (HA) around smooth muscle cells in lesions of atherosclerosis in diabetic patients suggests that this protein plays an important role in diabetic angiopathy. The aim of this study was to determine the correlation between serum HA concentrations and diabetic angiopathy. Diabetic patients treated with or without an oral hypoglycemic agent and/or insulin for at least 1 year were recruited (n = 95). We also included 20 non-diabetic control subjects. We measured serum levels of HA, body mass index (BMI), fasting plasma glucose (FPG), HbA1c, total cholesterol, triglyceride, glycated albumin (GA), high sensitivity CRP (hs-CRP), monocyte chemoattractant protein (MCP)-1 and evaluated diabetes mellitus history, drug use and presence of related complications. Serum HA levels were significantly (P<0.05) higher in diabetic patients (83.6 ± 5.6 ng/ml, mean ± SEM) than in normal subjects (41.7 ± 12 ng/ml). In diabetic patients, serum HA concentration significantly correlated with FPG, HbA1c, GA, triglyceride and also significantly correlated with BMI, hs-CRP and MCP-1 and tended to be higher in diabetic patients with complications than in those without such complications. Our data suggest that serum HA level correlates with poor blood glucose control and diabetic angiopathy and that it could be used as a marker of diabetic angiopathy.</abstract><cop>Japan</cop><pub>The Japan Endocrine Society</pub><pmid>16966827</pmid><doi>10.1507/endocrj.K05-119</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0918-8959 |
| ispartof | Endocrine Journal, 2006, Vol.53(6), pp.761-766 |
| issn | 0918-8959 1348-4540 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68275685 |
| source | J-STAGE Free; MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Angiopathy Blood Glucose - analysis Body Mass Index C-Reactive Protein - analysis Chemokine CCL2 - blood Complication Diabetes control Diabetes mellitus Diabetes Mellitus, Type 2 - blood Diabetic Angiopathies - blood Glycated Hemoglobin A Hemoglobins - analysis Humans Hyaluronic Acid - blood Serum Albumin - analysis Serum hyaluronic acid Triglycerides - blood |
| title | Serum Hyaluronan Concentration as a Marker of Angiopathy in Patients with Diabetes Mellitus |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-01T16%3A30%3A36IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Serum%20Hyaluronan%20Concentration%20as%20a%20Marker%20of%20Angiopathy%20in%20Patients%20with%20Diabetes%20Mellitus&rft.jtitle=Endocrine%20Journal&rft.au=MINE,%20Shinichiro&rft.date=2006&rft.volume=53&rft.issue=6&rft.spage=761&rft.epage=766&rft.pages=761-766&rft.issn=0918-8959&rft.eissn=1348-4540&rft_id=info:doi/10.1507/endocrj.K05-119&rft_dat=%3Cproquest_cross%3E68275685%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=68275685&rft_id=info:pmid/16966827&rfr_iscdi=true |