Disturbed surround inhibition in preclinical parkinsonism
Abstract Objective Surround inhibition in the motor system is an essential mechanism for selective execution of desired movements. To evaluate the functional operation of surround inhibition in Parkinson disease, we performed a transcranial magnetic stimulation (TMS) study in the asymptomatic hands...
Gespeichert in:
| Veröffentlicht in: | Clinical neurophysiology 2007-10, Vol.118 (10), p.2176-2179 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2179 |
|---|---|
| container_issue | 10 |
| container_start_page | 2176 |
| container_title | Clinical neurophysiology |
| container_volume | 118 |
| creator | Shin, Hae-Won Kang, Suk Y Sohn, Young H |
| description | Abstract Objective Surround inhibition in the motor system is an essential mechanism for selective execution of desired movements. To evaluate the functional operation of surround inhibition in Parkinson disease, we performed a transcranial magnetic stimulation (TMS) study in the asymptomatic hands of hemiparkinsonism patients. Methods TMS was set to be triggered by self-initiated flexion of the index finger at different intervals from 3 to 2000 ms. Average motor evoked potential (MEP) amplitudes obtained from self-triggered TMS were normalized to average MEPs of control TMS at rest. Normalized MEP amplitudes of the patients’ self-triggered TMS sessions at different intervals were compared to those of the controls. Results During index finger flexion, MEP amplitudes from the little finger muscle were unchanged in normal subjects. However, they were enhanced in Parkinson patients, despite the absence of any motor disturbance. Conclusions These results suggest that the functional operation of surround inhibition is impaired in Parkinson disease. This disturbance may precede motor disturbance in Parkinson disease. Significance Impaired surround inhibition can be useful to detect preclinical parkinsonism. |
| doi_str_mv | 10.1016/j.clinph.2007.06.058 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68275629</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1388245707003288</els_id><sourcerecordid>68275629</sourcerecordid><originalsourceid>FETCH-LOGICAL-c511t-c1a5db021fa85496a8a4d5a8b60f49c6d1aad13ca60c27fb47d852a2473a59513</originalsourceid><addsrcrecordid>eNqFkU1P3DAQhq2qFVDKP6iqvZRb0rHjr1yQKqAfEhIH6Nma2I7wknWCnSDx73G0WyH10pPn8Mw71vMS8plCTYHKb9vaDiFODzUDUDXIGoR-R06oVqzSrWDvy9xoXTEu1DH5mPMWCgicHZFjqhS0TKsT0l6FPC-p826Tl5TGJbpNiA-hC3MYYxk3U_LroWBx2EyYHkPMYwx594l86HHI_uzwnpI_P67vL39VN7c_f19-v6msoHSuLEXhOmC0Ry14K1EjdwJ1J6HnrZWOIjraWJRgmeo7rpwWDBlXDYpW0OaUnO9zpzQ-LT7PZhey9cOA0Y9LNlIzJSRrC8j3oE1jzsn3Zkphh-nFUDCrMrM1e2VmVWZAmqKsrH055C_dzru3pYOjAnw9AJiLhD5htCG_cS0FrTQv3MWe88XGc_DJZBt8tN6FonA2bgz_-8m_AX_FP_oXn7fjkmIxbajJzIC5W-td2y2tQsO0bl4BZtag6Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>68275629</pqid></control><display><type>article</type><title>Disturbed surround inhibition in preclinical parkinsonism</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Shin, Hae-Won ; Kang, Suk Y ; Sohn, Young H</creator><creatorcontrib>Shin, Hae-Won ; Kang, Suk Y ; Sohn, Young H</creatorcontrib><description>Abstract Objective Surround inhibition in the motor system is an essential mechanism for selective execution of desired movements. To evaluate the functional operation of surround inhibition in Parkinson disease, we performed a transcranial magnetic stimulation (TMS) study in the asymptomatic hands of hemiparkinsonism patients. Methods TMS was set to be triggered by self-initiated flexion of the index finger at different intervals from 3 to 2000 ms. Average motor evoked potential (MEP) amplitudes obtained from self-triggered TMS were normalized to average MEPs of control TMS at rest. Normalized MEP amplitudes of the patients’ self-triggered TMS sessions at different intervals were compared to those of the controls. Results During index finger flexion, MEP amplitudes from the little finger muscle were unchanged in normal subjects. However, they were enhanced in Parkinson patients, despite the absence of any motor disturbance. Conclusions These results suggest that the functional operation of surround inhibition is impaired in Parkinson disease. This disturbance may precede motor disturbance in Parkinson disease. Significance Impaired surround inhibition can be useful to detect preclinical parkinsonism.</description><identifier>ISSN: 1388-2457</identifier><identifier>EISSN: 1872-8952</identifier><identifier>DOI: 10.1016/j.clinph.2007.06.058</identifier><identifier>PMID: 17709287</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Aged ; Basal ganglia ; Biological and medical sciences ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Electromyography ; Evoked Potentials, Motor - physiology ; Female ; Fingers - innervation ; Fingers - physiology ; Functional Laterality - physiology ; Fundamental and applied biological sciences. Psychology ; Hand - physiopathology ; Humans ; Male ; Medical sciences ; Middle Aged ; Motor control ; Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration ; Movement - physiology ; Neurology ; Parkinson disease ; Parkinson Disease - diagnosis ; Parkinson Disease - physiopathology ; TMS ; Transcranial Magnetic Stimulation ; Tremor - physiopathology ; Vertebrates: nervous system and sense organs</subject><ispartof>Clinical neurophysiology, 2007-10, Vol.118 (10), p.2176-2179</ispartof><rights>International Federation of Clinical Neurophysiology</rights><rights>2007 International Federation of Clinical Neurophysiology</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c511t-c1a5db021fa85496a8a4d5a8b60f49c6d1aad13ca60c27fb47d852a2473a59513</citedby><cites>FETCH-LOGICAL-c511t-c1a5db021fa85496a8a4d5a8b60f49c6d1aad13ca60c27fb47d852a2473a59513</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1388245707003288$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19108784$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17709287$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shin, Hae-Won</creatorcontrib><creatorcontrib>Kang, Suk Y</creatorcontrib><creatorcontrib>Sohn, Young H</creatorcontrib><title>Disturbed surround inhibition in preclinical parkinsonism</title><title>Clinical neurophysiology</title><addtitle>Clin Neurophysiol</addtitle><description>Abstract Objective Surround inhibition in the motor system is an essential mechanism for selective execution of desired movements. To evaluate the functional operation of surround inhibition in Parkinson disease, we performed a transcranial magnetic stimulation (TMS) study in the asymptomatic hands of hemiparkinsonism patients. Methods TMS was set to be triggered by self-initiated flexion of the index finger at different intervals from 3 to 2000 ms. Average motor evoked potential (MEP) amplitudes obtained from self-triggered TMS were normalized to average MEPs of control TMS at rest. Normalized MEP amplitudes of the patients’ self-triggered TMS sessions at different intervals were compared to those of the controls. Results During index finger flexion, MEP amplitudes from the little finger muscle were unchanged in normal subjects. However, they were enhanced in Parkinson patients, despite the absence of any motor disturbance. Conclusions These results suggest that the functional operation of surround inhibition is impaired in Parkinson disease. This disturbance may precede motor disturbance in Parkinson disease. Significance Impaired surround inhibition can be useful to detect preclinical parkinsonism.</description><subject>Aged</subject><subject>Basal ganglia</subject><subject>Biological and medical sciences</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Electromyography</subject><subject>Evoked Potentials, Motor - physiology</subject><subject>Female</subject><subject>Fingers - innervation</subject><subject>Fingers - physiology</subject><subject>Functional Laterality - physiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hand - physiopathology</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Motor control</subject><subject>Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration</subject><subject>Movement - physiology</subject><subject>Neurology</subject><subject>Parkinson disease</subject><subject>Parkinson Disease - diagnosis</subject><subject>Parkinson Disease - physiopathology</subject><subject>TMS</subject><subject>Transcranial Magnetic Stimulation</subject><subject>Tremor - physiopathology</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>1388-2457</issn><issn>1872-8952</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1P3DAQhq2qFVDKP6iqvZRb0rHjr1yQKqAfEhIH6Nma2I7wknWCnSDx73G0WyH10pPn8Mw71vMS8plCTYHKb9vaDiFODzUDUDXIGoR-R06oVqzSrWDvy9xoXTEu1DH5mPMWCgicHZFjqhS0TKsT0l6FPC-p826Tl5TGJbpNiA-hC3MYYxk3U_LroWBx2EyYHkPMYwx594l86HHI_uzwnpI_P67vL39VN7c_f19-v6msoHSuLEXhOmC0Ry14K1EjdwJ1J6HnrZWOIjraWJRgmeo7rpwWDBlXDYpW0OaUnO9zpzQ-LT7PZhey9cOA0Y9LNlIzJSRrC8j3oE1jzsn3Zkphh-nFUDCrMrM1e2VmVWZAmqKsrH055C_dzru3pYOjAnw9AJiLhD5htCG_cS0FrTQv3MWe88XGc_DJZBt8tN6FonA2bgz_-8m_AX_FP_oXn7fjkmIxbajJzIC5W-td2y2tQsO0bl4BZtag6Q</recordid><startdate>20071001</startdate><enddate>20071001</enddate><creator>Shin, Hae-Won</creator><creator>Kang, Suk Y</creator><creator>Sohn, Young H</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20071001</creationdate><title>Disturbed surround inhibition in preclinical parkinsonism</title><author>Shin, Hae-Won ; Kang, Suk Y ; Sohn, Young H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c511t-c1a5db021fa85496a8a4d5a8b60f49c6d1aad13ca60c27fb47d852a2473a59513</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Aged</topic><topic>Basal ganglia</topic><topic>Biological and medical sciences</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Electromyography</topic><topic>Evoked Potentials, Motor - physiology</topic><topic>Female</topic><topic>Fingers - innervation</topic><topic>Fingers - physiology</topic><topic>Functional Laterality - physiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hand - physiopathology</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Motor control</topic><topic>Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration</topic><topic>Movement - physiology</topic><topic>Neurology</topic><topic>Parkinson disease</topic><topic>Parkinson Disease - diagnosis</topic><topic>Parkinson Disease - physiopathology</topic><topic>TMS</topic><topic>Transcranial Magnetic Stimulation</topic><topic>Tremor - physiopathology</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shin, Hae-Won</creatorcontrib><creatorcontrib>Kang, Suk Y</creatorcontrib><creatorcontrib>Sohn, Young H</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical neurophysiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shin, Hae-Won</au><au>Kang, Suk Y</au><au>Sohn, Young H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Disturbed surround inhibition in preclinical parkinsonism</atitle><jtitle>Clinical neurophysiology</jtitle><addtitle>Clin Neurophysiol</addtitle><date>2007-10-01</date><risdate>2007</risdate><volume>118</volume><issue>10</issue><spage>2176</spage><epage>2179</epage><pages>2176-2179</pages><issn>1388-2457</issn><eissn>1872-8952</eissn><abstract>Abstract Objective Surround inhibition in the motor system is an essential mechanism for selective execution of desired movements. To evaluate the functional operation of surround inhibition in Parkinson disease, we performed a transcranial magnetic stimulation (TMS) study in the asymptomatic hands of hemiparkinsonism patients. Methods TMS was set to be triggered by self-initiated flexion of the index finger at different intervals from 3 to 2000 ms. Average motor evoked potential (MEP) amplitudes obtained from self-triggered TMS were normalized to average MEPs of control TMS at rest. Normalized MEP amplitudes of the patients’ self-triggered TMS sessions at different intervals were compared to those of the controls. Results During index finger flexion, MEP amplitudes from the little finger muscle were unchanged in normal subjects. However, they were enhanced in Parkinson patients, despite the absence of any motor disturbance. Conclusions These results suggest that the functional operation of surround inhibition is impaired in Parkinson disease. This disturbance may precede motor disturbance in Parkinson disease. Significance Impaired surround inhibition can be useful to detect preclinical parkinsonism.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>17709287</pmid><doi>10.1016/j.clinph.2007.06.058</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1388-2457 |
| ispartof | Clinical neurophysiology, 2007-10, Vol.118 (10), p.2176-2179 |
| issn | 1388-2457 1872-8952 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68275629 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Aged Basal ganglia Biological and medical sciences Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Electromyography Evoked Potentials, Motor - physiology Female Fingers - innervation Fingers - physiology Functional Laterality - physiology Fundamental and applied biological sciences. Psychology Hand - physiopathology Humans Male Medical sciences Middle Aged Motor control Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration Movement - physiology Neurology Parkinson disease Parkinson Disease - diagnosis Parkinson Disease - physiopathology TMS Transcranial Magnetic Stimulation Tremor - physiopathology Vertebrates: nervous system and sense organs |
| title | Disturbed surround inhibition in preclinical parkinsonism |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-23T17%3A58%3A59IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Disturbed%20surround%20inhibition%20in%20preclinical%20parkinsonism&rft.jtitle=Clinical%20neurophysiology&rft.au=Shin,%20Hae-Won&rft.date=2007-10-01&rft.volume=118&rft.issue=10&rft.spage=2176&rft.epage=2179&rft.pages=2176-2179&rft.issn=1388-2457&rft.eissn=1872-8952&rft_id=info:doi/10.1016/j.clinph.2007.06.058&rft_dat=%3Cproquest_cross%3E68275629%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=68275629&rft_id=info:pmid/17709287&rft_els_id=S1388245707003288&rfr_iscdi=true |