Participation of the Endocannabinoid System in the Effect of TNF-α on Hypothalamic Release of Gonadotropin-Releasing Hormone

: It is known that Δ9‐tetrahydrocannabinol (THC), the major active ingredient of marijuana, can suppress reproductive function. Also, we reported previously that the endocannabinoid, anandamide (AEA), inhibited gonadotropin‐releasing hormone (LHRH) release from medial basal hypothalamus (MBH) of ma...

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Veröffentlicht in:	Annals of the New York Academy of Sciences 2006-11, Vol.1088 (1), p.238-250
Hauptverfasser:	FERNANDEZ-SOLARI, JAVIER, PRESTIFILIPPO, JUAN P., BORNSTEIN, STEFAN R., McCANN, SAMUEL M., RETTORI, VALERIA
Format:	Artikel
Sprache:	eng
Schlagworte:	AM251 Amidohydrolases - metabolism anandamide Animals cAMP Cannabinoid Receptor Modulators - metabolism CB1 receptor Colforsin - pharmacology Cyclic AMP - metabolism Endocannabinoids Enzyme Activation - drug effects Gonadotropin-Releasing Hormone - metabolism Hypothalamus - drug effects Hypothalamus - immunology Hypothalamus - metabolism Injections, Intraperitoneal Injections, Intraventricular Lipopolysaccharides - pharmacology LPS Male Rats Rats, Wistar Receptor, Cannabinoid, CB1 - metabolism Tumor Necrosis Factor-alpha - metabolism Tumor Necrosis Factor-alpha - pharmacology
Online-Zugang:	Volltext
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