Analysis of the neoplastic nature and biological potential of sporadic and nevoid basal cell carcinoma syndrome-associated keratocystic odontogenic tumor
Background: Keratocystic odontogenic tumor (KCOT), also known as odontogenic keratocyst, is a benign cystic neoplasm, which may be associated with nevoid basal cell carcinoma syndrome (NBCCS) and if it does, will occur as multiple cystic lesions. KCOT is locally destructive despite its bland histol...
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| Veröffentlicht in: | Journal of oral pathology & medicine 2007-10, Vol.36 (9), p.550-554 |
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| creator | Katase, Naoki Nagatsuka, Hitoshi Tsujigiwa, Hidetsugu Gunduz, Mehmet Tamamura, Ryo Pwint, Han Phuu Rivera, Rosario Santos Nakajima, Motowo Naomoto, Yoshio Nagai, Noriyuki |
| description | Background: Keratocystic odontogenic tumor (KCOT), also known as odontogenic keratocyst, is a benign cystic neoplasm, which may be associated with nevoid basal cell carcinoma syndrome (NBCCS) and if it does, will occur as multiple cystic lesions. KCOT is locally destructive despite its bland histological features. However, the neoplastic nature of KCOT is not well established.
Heparanase is an endo‐d‐glucuronidase enzyme that specifically cleaves heparan sulfate (HS) and the increase of its level in tumors promotes invasion, angiogenesis, and metastasis.
Methods: To investigate the neoplastic character of KCOT, we studied the localization patterns of heparanase in KCOT, focusing on the differences between sporadic and NBCCS‐associated KCOTs, by immunohistochemistry and in situ hybridization. To compare the expression pattern of these cysts with non‐tumorous odontogenic developmental cyst, dentigerous cyst was included.
Results: All the odontogenic cysts showed positive immunoreaction for heparanase protein in various intensities. The expression pattern of heparanase gene corresponded to that of protein expression. Interestingly, intense gene and protein expressions were observed in KCOT associated with NBCCS compared with sporadic ones and dentigerous cyst.
Conclusions: The results implied that heparanase expression may be correlated with the neoplastic properties of KCOT, particularly in NBCCS‐associated cases. |
| doi_str_mv | 10.1111/j.1600-0714.2007.00578.x |
| format | Article |
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Heparanase is an endo‐d‐glucuronidase enzyme that specifically cleaves heparan sulfate (HS) and the increase of its level in tumors promotes invasion, angiogenesis, and metastasis.
Methods: To investigate the neoplastic character of KCOT, we studied the localization patterns of heparanase in KCOT, focusing on the differences between sporadic and NBCCS‐associated KCOTs, by immunohistochemistry and in situ hybridization. To compare the expression pattern of these cysts with non‐tumorous odontogenic developmental cyst, dentigerous cyst was included.
Results: All the odontogenic cysts showed positive immunoreaction for heparanase protein in various intensities. The expression pattern of heparanase gene corresponded to that of protein expression. Interestingly, intense gene and protein expressions were observed in KCOT associated with NBCCS compared with sporadic ones and dentigerous cyst.
Conclusions: The results implied that heparanase expression may be correlated with the neoplastic properties of KCOT, particularly in NBCCS‐associated cases.</description><identifier>ISSN: 0904-2512</identifier><identifier>EISSN: 1600-0714</identifier><identifier>DOI: 10.1111/j.1600-0714.2007.00578.x</identifier><identifier>PMID: 17850439</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Basal Cell Nevus Syndrome - complications ; Basal Cell Nevus Syndrome - enzymology ; Biological and medical sciences ; Dentigerous Cyst - enzymology ; Dentistry ; Dermatology ; Gene Expression Regulation, Neoplastic ; Glucuronidase - biosynthesis ; Glucuronidase - genetics ; Heparan Sulfate Proteoglycans - metabolism ; heparanase ; Humans ; Immunohistochemistry ; In Situ Hybridization ; keratocystic odontogenic tumor ; Medical sciences ; Neoplasm Invasiveness ; Odontogenic Cysts - complications ; Odontogenic Cysts - enzymology ; Odontogenic Tumors - complications ; Odontogenic Tumors - enzymology ; Otorhinolaryngology. Stomatology ; Tumors of the skin and soft tissue. Premalignant lesions</subject><ispartof>Journal of oral pathology & medicine, 2007-10, Vol.36 (9), p.550-554</ispartof><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5008-d5fdde99988e4c58973cf17c30848ff369fd448d809f0a395cc7a284fdb200293</citedby><cites>FETCH-LOGICAL-c5008-d5fdde99988e4c58973cf17c30848ff369fd448d809f0a395cc7a284fdb200293</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1600-0714.2007.00578.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1600-0714.2007.00578.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19066172$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17850439$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Katase, Naoki</creatorcontrib><creatorcontrib>Nagatsuka, Hitoshi</creatorcontrib><creatorcontrib>Tsujigiwa, Hidetsugu</creatorcontrib><creatorcontrib>Gunduz, Mehmet</creatorcontrib><creatorcontrib>Tamamura, Ryo</creatorcontrib><creatorcontrib>Pwint, Han Phuu</creatorcontrib><creatorcontrib>Rivera, Rosario Santos</creatorcontrib><creatorcontrib>Nakajima, Motowo</creatorcontrib><creatorcontrib>Naomoto, Yoshio</creatorcontrib><creatorcontrib>Nagai, Noriyuki</creatorcontrib><title>Analysis of the neoplastic nature and biological potential of sporadic and nevoid basal cell carcinoma syndrome-associated keratocystic odontogenic tumor</title><title>Journal of oral pathology & medicine</title><addtitle>J Oral Pathol Med</addtitle><description>Background: Keratocystic odontogenic tumor (KCOT), also known as odontogenic keratocyst, is a benign cystic neoplasm, which may be associated with nevoid basal cell carcinoma syndrome (NBCCS) and if it does, will occur as multiple cystic lesions. KCOT is locally destructive despite its bland histological features. However, the neoplastic nature of KCOT is not well established.
Heparanase is an endo‐d‐glucuronidase enzyme that specifically cleaves heparan sulfate (HS) and the increase of its level in tumors promotes invasion, angiogenesis, and metastasis.
Methods: To investigate the neoplastic character of KCOT, we studied the localization patterns of heparanase in KCOT, focusing on the differences between sporadic and NBCCS‐associated KCOTs, by immunohistochemistry and in situ hybridization. To compare the expression pattern of these cysts with non‐tumorous odontogenic developmental cyst, dentigerous cyst was included.
Results: All the odontogenic cysts showed positive immunoreaction for heparanase protein in various intensities. The expression pattern of heparanase gene corresponded to that of protein expression. Interestingly, intense gene and protein expressions were observed in KCOT associated with NBCCS compared with sporadic ones and dentigerous cyst.
Conclusions: The results implied that heparanase expression may be correlated with the neoplastic properties of KCOT, particularly in NBCCS‐associated cases.</description><subject>Basal Cell Nevus Syndrome - complications</subject><subject>Basal Cell Nevus Syndrome - enzymology</subject><subject>Biological and medical sciences</subject><subject>Dentigerous Cyst - enzymology</subject><subject>Dentistry</subject><subject>Dermatology</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Glucuronidase - biosynthesis</subject><subject>Glucuronidase - genetics</subject><subject>Heparan Sulfate Proteoglycans - metabolism</subject><subject>heparanase</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>In Situ Hybridization</subject><subject>keratocystic odontogenic tumor</subject><subject>Medical sciences</subject><subject>Neoplasm Invasiveness</subject><subject>Odontogenic Cysts - complications</subject><subject>Odontogenic Cysts - enzymology</subject><subject>Odontogenic Tumors - complications</subject><subject>Odontogenic Tumors - enzymology</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Tumors of the skin and soft tissue. Premalignant lesions</subject><issn>0904-2512</issn><issn>1600-0714</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc1u1DAUhS0EotPCK6BsYJdgx0lsS2yqig5FFa1Q-dlZHv8UTxM7tR2YPApvi9MZtVu8sK90v-N7dQ4ABYIVyuf9tkIdhCUkqKlqCEkFYUtotXsGVo-N52AFGWzKukX1ETiOcQshIrhBL8ERIrSFDWYr8PfUiX6ONhbeFOmXLpz2Yy9isrJwIk1BF8KpYmN972-tFH0x-qRdsrnKijj6IFRmF8jp395mVsTclLrPlwjSOj-IIs5OBT_oUsTopRVJq-JOB5G8nB-GeeVd8rfa5TpNgw-vwAsj-qhfH94T8O38483Zp_Lyan1xdnpZyhZCWqrWKKUZY5TqRraUESwNIhJD2lBjcMeMahqqKGQGCsxaKYmoaWPUJjtXM3wC3u3_HYO_n3RMfLBx2V5kK6bIO1qTmlGSQboHZfAxBm34GOwgwswR5EssfMsX9_niPl9i4Q-x8F2WvjnMmDaDVk_CQw4ZeHsARMwmmyCctPGJY7DrEKkz92HP_bG9nv97Af756joXWV7u5TYmvXuUi3DHO4JJy398WfPvP7_WeH1zzc_xP2I1u3w</recordid><startdate>200710</startdate><enddate>200710</enddate><creator>Katase, Naoki</creator><creator>Nagatsuka, Hitoshi</creator><creator>Tsujigiwa, Hidetsugu</creator><creator>Gunduz, Mehmet</creator><creator>Tamamura, Ryo</creator><creator>Pwint, Han Phuu</creator><creator>Rivera, Rosario Santos</creator><creator>Nakajima, Motowo</creator><creator>Naomoto, Yoshio</creator><creator>Nagai, Noriyuki</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200710</creationdate><title>Analysis of the neoplastic nature and biological potential of sporadic and nevoid basal cell carcinoma syndrome-associated keratocystic odontogenic tumor</title><author>Katase, Naoki ; Nagatsuka, Hitoshi ; Tsujigiwa, Hidetsugu ; Gunduz, Mehmet ; Tamamura, Ryo ; Pwint, Han Phuu ; Rivera, Rosario Santos ; Nakajima, Motowo ; Naomoto, Yoshio ; Nagai, Noriyuki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5008-d5fdde99988e4c58973cf17c30848ff369fd448d809f0a395cc7a284fdb200293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Basal Cell Nevus Syndrome - complications</topic><topic>Basal Cell Nevus Syndrome - enzymology</topic><topic>Biological and medical sciences</topic><topic>Dentigerous Cyst - enzymology</topic><topic>Dentistry</topic><topic>Dermatology</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Glucuronidase - biosynthesis</topic><topic>Glucuronidase - genetics</topic><topic>Heparan Sulfate Proteoglycans - metabolism</topic><topic>heparanase</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>In Situ Hybridization</topic><topic>keratocystic odontogenic tumor</topic><topic>Medical sciences</topic><topic>Neoplasm Invasiveness</topic><topic>Odontogenic Cysts - complications</topic><topic>Odontogenic Cysts - enzymology</topic><topic>Odontogenic Tumors - complications</topic><topic>Odontogenic Tumors - enzymology</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Tumors of the skin and soft tissue. Premalignant lesions</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Katase, Naoki</creatorcontrib><creatorcontrib>Nagatsuka, Hitoshi</creatorcontrib><creatorcontrib>Tsujigiwa, Hidetsugu</creatorcontrib><creatorcontrib>Gunduz, Mehmet</creatorcontrib><creatorcontrib>Tamamura, Ryo</creatorcontrib><creatorcontrib>Pwint, Han Phuu</creatorcontrib><creatorcontrib>Rivera, Rosario Santos</creatorcontrib><creatorcontrib>Nakajima, Motowo</creatorcontrib><creatorcontrib>Naomoto, Yoshio</creatorcontrib><creatorcontrib>Nagai, Noriyuki</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of oral pathology & medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Katase, Naoki</au><au>Nagatsuka, Hitoshi</au><au>Tsujigiwa, Hidetsugu</au><au>Gunduz, Mehmet</au><au>Tamamura, Ryo</au><au>Pwint, Han Phuu</au><au>Rivera, Rosario Santos</au><au>Nakajima, Motowo</au><au>Naomoto, Yoshio</au><au>Nagai, Noriyuki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Analysis of the neoplastic nature and biological potential of sporadic and nevoid basal cell carcinoma syndrome-associated keratocystic odontogenic tumor</atitle><jtitle>Journal of oral pathology & medicine</jtitle><addtitle>J Oral Pathol Med</addtitle><date>2007-10</date><risdate>2007</risdate><volume>36</volume><issue>9</issue><spage>550</spage><epage>554</epage><pages>550-554</pages><issn>0904-2512</issn><eissn>1600-0714</eissn><abstract>Background: Keratocystic odontogenic tumor (KCOT), also known as odontogenic keratocyst, is a benign cystic neoplasm, which may be associated with nevoid basal cell carcinoma syndrome (NBCCS) and if it does, will occur as multiple cystic lesions. KCOT is locally destructive despite its bland histological features. However, the neoplastic nature of KCOT is not well established.
Heparanase is an endo‐d‐glucuronidase enzyme that specifically cleaves heparan sulfate (HS) and the increase of its level in tumors promotes invasion, angiogenesis, and metastasis.
Methods: To investigate the neoplastic character of KCOT, we studied the localization patterns of heparanase in KCOT, focusing on the differences between sporadic and NBCCS‐associated KCOTs, by immunohistochemistry and in situ hybridization. To compare the expression pattern of these cysts with non‐tumorous odontogenic developmental cyst, dentigerous cyst was included.
Results: All the odontogenic cysts showed positive immunoreaction for heparanase protein in various intensities. The expression pattern of heparanase gene corresponded to that of protein expression. Interestingly, intense gene and protein expressions were observed in KCOT associated with NBCCS compared with sporadic ones and dentigerous cyst.
Conclusions: The results implied that heparanase expression may be correlated with the neoplastic properties of KCOT, particularly in NBCCS‐associated cases.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>17850439</pmid><doi>10.1111/j.1600-0714.2007.00578.x</doi><tpages>5</tpages></addata></record> |
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| source | Wiley Online Library - AutoHoldings Journals; MEDLINE |
| subjects | Basal Cell Nevus Syndrome - complications Basal Cell Nevus Syndrome - enzymology Biological and medical sciences Dentigerous Cyst - enzymology Dentistry Dermatology Gene Expression Regulation, Neoplastic Glucuronidase - biosynthesis Glucuronidase - genetics Heparan Sulfate Proteoglycans - metabolism heparanase Humans Immunohistochemistry In Situ Hybridization keratocystic odontogenic tumor Medical sciences Neoplasm Invasiveness Odontogenic Cysts - complications Odontogenic Cysts - enzymology Odontogenic Tumors - complications Odontogenic Tumors - enzymology Otorhinolaryngology. Stomatology Tumors of the skin and soft tissue. Premalignant lesions |
| title | Analysis of the neoplastic nature and biological potential of sporadic and nevoid basal cell carcinoma syndrome-associated keratocystic odontogenic tumor |
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