Influence of 3-hydroxy-3-methylglutaryl Coenzyme A Reductase Inhibitors on Ubiquinone Levels in Rat Skeletal Muscle and Heart: Relationship to Cytotoxicity and Inhibitory Activity for Cholesterol Synthesis in Human Skeletal Muscle Cells

Although statins are prescribed as relatively safe and effective drugs for hypercholesterolemic patients, it has been reported that a significant side effect, myopathy, occurs infrequently during medication. Moreover, because statins decrease cardiac ubiquinone levels, the risk of cardiac dysfunctio...

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Veröffentlicht in:	Journal of Atherosclerosis and Thrombosis 2006, Vol.13(6), pp.295-307
Hauptverfasser:	Yamazaki, Hiroyuki, Suzuki, Mahomi, Aoki, Taro, Morikawa, Shigeru, Maejima, Takashi, Sato, Fumiyasu, Sawanobori, Kimio, Kitahara, Masaki, Kodama, Tatsuhiko, Saito, Yasushi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Survival - drug effects Cells, Cultured Cholesterol - biosynthesis Cholesterol - metabolism Cytotoxicity Enzymes - blood Enzymes - drug effects Heart - drug effects Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors Lipids - blood Male Muscle Proteins - drug effects Muscle Proteins - metabolism Muscle, Skeletal - cytology Muscle, Skeletal - drug effects Muscle, Skeletal - metabolism Myocardium - metabolism Myopathy Rats Rats, Wistar Statin Ubiquinone Ubiquinone - metabolism
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