The Role of Distal S6 Hydrophobic Residues in the Voltage-dependent Gating of CaV2.3 Channels

The hydrophobic locus VAVIM is conserved in the S6 transmembrane segment of domain IV (IVS6) in CaV1 and CaV2 families. Herein we show that glycine substitution of the VAVIM motif in CaV2.3 produced whole cell currents with inactivation kinetics that were either slower (A1719G ≈ V1720G), similar (V1...

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