Early weight bearing of porous HA/TCP (60/40) ceramics in vivo: A longitudinal study in a segmental bone defect model of rabbit
Porous interconnected hydroxyapatite (HA) and HA/tricalcium phosphate (TCP) (60/40) ceramics are promising materials for hard tissue repair. However, the mechanical properties of these materials have not been accurately determined under weight-bearing conditions. In this study, newly developed HA an...
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| Veröffentlicht in: | Acta biomaterialia 2007-11, Vol.3 (6), p.985-996 |
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| container_title | Acta biomaterialia |
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| creator | Balçik, Cenk Tokdemir, Turgut Şenköylü, Alpaslan Koç, Nurşen Timuçin, Muharrem Akin, Serhat Korkusuz, Petek Korkusuz, Feza |
| description | Porous interconnected hydroxyapatite (HA) and HA/tricalcium phosphate (TCP) (60/40) ceramics are promising materials for hard tissue repair. However, the mechanical properties of these materials have not been accurately determined under weight-bearing conditions. In this study, newly developed HA and HA/TCP (60/40) ceramics were used with intramedullary fixation in segmental bone defects of rabbits. Early radiological, histological, densitometric and biomechanical changes were evaluated. The mean radiological grade of healing and bonding to bone was higher in HA/TCP (60/40) ceramics than that of pure HA ceramics but the difference was not statistically significant. The densities of both implanted ceramics improved with time, supported by the histological evaluation of bone matrix ingrowth into ceramic pores, whereas the densities at the bone–ceramic interface decreased gradually. Flexural resonant frequencies and three-point bending strength increased, revealing an increase in mechanical stability during this early critical time interval where implant and/or bone–implant interface failures occur frequently. It can be concluded that both HA and HA/TCP (60/40) ceramics have a limited application in the treatment of load-bearing segmental bone defects but did not fail at the early stages of implantation. |
| doi_str_mv | 10.1016/j.actbio.2007.04.004 |
| format | Article |
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However, the mechanical properties of these materials have not been accurately determined under weight-bearing conditions. In this study, newly developed HA and HA/TCP (60/40) ceramics were used with intramedullary fixation in segmental bone defects of rabbits. Early radiological, histological, densitometric and biomechanical changes were evaluated. The mean radiological grade of healing and bonding to bone was higher in HA/TCP (60/40) ceramics than that of pure HA ceramics but the difference was not statistically significant. The densities of both implanted ceramics improved with time, supported by the histological evaluation of bone matrix ingrowth into ceramic pores, whereas the densities at the bone–ceramic interface decreased gradually. Flexural resonant frequencies and three-point bending strength increased, revealing an increase in mechanical stability during this early critical time interval where implant and/or bone–implant interface failures occur frequently. It can be concluded that both HA and HA/TCP (60/40) ceramics have a limited application in the treatment of load-bearing segmental bone defects but did not fail at the early stages of implantation.</description><identifier>ISSN: 1742-7061</identifier><identifier>EISSN: 1878-7568</identifier><identifier>DOI: 10.1016/j.actbio.2007.04.004</identifier><identifier>PMID: 17574942</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Animals ; Biocompatible Materials ; Biomechanics ; Bone defect ; Bone Density ; Bone Diseases - diagnostic imaging ; Bone Diseases - pathology ; Bone Diseases - physiopathology ; Bone Diseases - surgery ; Calcium phosphate ceramic ; Calcium Phosphates - chemistry ; Ceramics - chemistry ; Disease Models, Animal ; Durapatite - chemistry ; Early weight bearing ; Hydroxyapatite ; Longitudinal Studies ; Materials Testing ; Microscopy, Electron, Scanning ; Porosity ; Rabbits ; Radiography ; Time Factors ; Tomography Scanners, X-Ray Computed ; Weight-Bearing ; Wound Healing ; X-Ray Diffraction</subject><ispartof>Acta biomaterialia, 2007-11, Vol.3 (6), p.985-996</ispartof><rights>2007 Acta Materialia Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c488t-96793d24043e33c9ffcb725d3e311152aaf2eb2e94f17ea390696fd21b171c773</citedby><cites>FETCH-LOGICAL-c488t-96793d24043e33c9ffcb725d3e311152aaf2eb2e94f17ea390696fd21b171c773</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1742706107000621$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17574942$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Balçik, Cenk</creatorcontrib><creatorcontrib>Tokdemir, Turgut</creatorcontrib><creatorcontrib>Şenköylü, Alpaslan</creatorcontrib><creatorcontrib>Koç, Nurşen</creatorcontrib><creatorcontrib>Timuçin, Muharrem</creatorcontrib><creatorcontrib>Akin, Serhat</creatorcontrib><creatorcontrib>Korkusuz, Petek</creatorcontrib><creatorcontrib>Korkusuz, Feza</creatorcontrib><title>Early weight bearing of porous HA/TCP (60/40) ceramics in vivo: A longitudinal study in a segmental bone defect model of rabbit</title><title>Acta biomaterialia</title><addtitle>Acta Biomater</addtitle><description>Porous interconnected hydroxyapatite (HA) and HA/tricalcium phosphate (TCP) (60/40) ceramics are promising materials for hard tissue repair. However, the mechanical properties of these materials have not been accurately determined under weight-bearing conditions. In this study, newly developed HA and HA/TCP (60/40) ceramics were used with intramedullary fixation in segmental bone defects of rabbits. Early radiological, histological, densitometric and biomechanical changes were evaluated. The mean radiological grade of healing and bonding to bone was higher in HA/TCP (60/40) ceramics than that of pure HA ceramics but the difference was not statistically significant. The densities of both implanted ceramics improved with time, supported by the histological evaluation of bone matrix ingrowth into ceramic pores, whereas the densities at the bone–ceramic interface decreased gradually. Flexural resonant frequencies and three-point bending strength increased, revealing an increase in mechanical stability during this early critical time interval where implant and/or bone–implant interface failures occur frequently. It can be concluded that both HA and HA/TCP (60/40) ceramics have a limited application in the treatment of load-bearing segmental bone defects but did not fail at the early stages of implantation.</description><subject>Animals</subject><subject>Biocompatible Materials</subject><subject>Biomechanics</subject><subject>Bone defect</subject><subject>Bone Density</subject><subject>Bone Diseases - diagnostic imaging</subject><subject>Bone Diseases - pathology</subject><subject>Bone Diseases - physiopathology</subject><subject>Bone Diseases - surgery</subject><subject>Calcium phosphate ceramic</subject><subject>Calcium Phosphates - chemistry</subject><subject>Ceramics - chemistry</subject><subject>Disease Models, Animal</subject><subject>Durapatite - chemistry</subject><subject>Early weight bearing</subject><subject>Hydroxyapatite</subject><subject>Longitudinal Studies</subject><subject>Materials Testing</subject><subject>Microscopy, Electron, Scanning</subject><subject>Porosity</subject><subject>Rabbits</subject><subject>Radiography</subject><subject>Time Factors</subject><subject>Tomography Scanners, X-Ray Computed</subject><subject>Weight-Bearing</subject><subject>Wound Healing</subject><subject>X-Ray Diffraction</subject><issn>1742-7061</issn><issn>1878-7568</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU2P0zAQhiMEYpeFf4CQTwgOSccfsRMOK1XVwiKtBIflbNnOpLhK4mKnRT3x13HUStzY03z4nXfkeYriLYWKApWrXWXcbH2oGICqQFQA4llxTRvVlKqWzfOcK8FKBZJeFa9S2gHwhrLmZXFFVa1EK9h18efOxOFEfqPf_pyJRRP9tCWhJ_sQwyGR-_XqcfOdfJCwEvCROIxm9C4RP5GjP4ZPZE2GMG39fOj8ZAaScnJaXg1JuB1xmnPThglJhz26mYyhw2FZEI21fn5dvOjNkPDNJd4UPz7fPW7uy4dvX75u1g-lE00zl61ULe-YAMGRc9f2vbOK1V2uKKU1M6ZnaBm2oqcKDW9BtrLvGLVUUacUvynen333Mfw6YJr16JPDYTAT5n9q2TBFmZJPCjlQDlK0TwoZiLoGWBzFWehiSClir_fRjyaeNAW9oNQ7fUapF5QahM4o89i7i__Bjtj9G7qwy4LbswDz3Y4eo07O4-Sw8zFfWnfB_3_DX2YCr2w</recordid><startdate>20071101</startdate><enddate>20071101</enddate><creator>Balçik, Cenk</creator><creator>Tokdemir, Turgut</creator><creator>Şenköylü, Alpaslan</creator><creator>Koç, Nurşen</creator><creator>Timuçin, Muharrem</creator><creator>Akin, Serhat</creator><creator>Korkusuz, Petek</creator><creator>Korkusuz, Feza</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7QP</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7SR</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>F28</scope><scope>JG9</scope><scope>L7M</scope><scope>7X8</scope></search><sort><creationdate>20071101</creationdate><title>Early weight bearing of porous HA/TCP (60/40) ceramics in vivo: A longitudinal study in a segmental bone defect model of rabbit</title><author>Balçik, Cenk ; Tokdemir, Turgut ; Şenköylü, Alpaslan ; Koç, Nurşen ; Timuçin, Muharrem ; Akin, Serhat ; Korkusuz, Petek ; Korkusuz, Feza</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c488t-96793d24043e33c9ffcb725d3e311152aaf2eb2e94f17ea390696fd21b171c773</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Animals</topic><topic>Biocompatible Materials</topic><topic>Biomechanics</topic><topic>Bone defect</topic><topic>Bone Density</topic><topic>Bone Diseases - diagnostic imaging</topic><topic>Bone Diseases - pathology</topic><topic>Bone Diseases - physiopathology</topic><topic>Bone Diseases - surgery</topic><topic>Calcium phosphate ceramic</topic><topic>Calcium Phosphates - chemistry</topic><topic>Ceramics - chemistry</topic><topic>Disease Models, Animal</topic><topic>Durapatite - chemistry</topic><topic>Early weight bearing</topic><topic>Hydroxyapatite</topic><topic>Longitudinal Studies</topic><topic>Materials Testing</topic><topic>Microscopy, Electron, Scanning</topic><topic>Porosity</topic><topic>Rabbits</topic><topic>Radiography</topic><topic>Time Factors</topic><topic>Tomography Scanners, X-Ray Computed</topic><topic>Weight-Bearing</topic><topic>Wound Healing</topic><topic>X-Ray Diffraction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Balçik, Cenk</creatorcontrib><creatorcontrib>Tokdemir, Turgut</creatorcontrib><creatorcontrib>Şenköylü, Alpaslan</creatorcontrib><creatorcontrib>Koç, Nurşen</creatorcontrib><creatorcontrib>Timuçin, Muharrem</creatorcontrib><creatorcontrib>Akin, Serhat</creatorcontrib><creatorcontrib>Korkusuz, Petek</creatorcontrib><creatorcontrib>Korkusuz, Feza</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Acta biomaterialia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Balçik, Cenk</au><au>Tokdemir, Turgut</au><au>Şenköylü, Alpaslan</au><au>Koç, Nurşen</au><au>Timuçin, Muharrem</au><au>Akin, Serhat</au><au>Korkusuz, Petek</au><au>Korkusuz, Feza</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Early weight bearing of porous HA/TCP (60/40) ceramics in vivo: A longitudinal study in a segmental bone defect model of rabbit</atitle><jtitle>Acta biomaterialia</jtitle><addtitle>Acta Biomater</addtitle><date>2007-11-01</date><risdate>2007</risdate><volume>3</volume><issue>6</issue><spage>985</spage><epage>996</epage><pages>985-996</pages><issn>1742-7061</issn><eissn>1878-7568</eissn><abstract>Porous interconnected hydroxyapatite (HA) and HA/tricalcium phosphate (TCP) (60/40) ceramics are promising materials for hard tissue repair. However, the mechanical properties of these materials have not been accurately determined under weight-bearing conditions. In this study, newly developed HA and HA/TCP (60/40) ceramics were used with intramedullary fixation in segmental bone defects of rabbits. Early radiological, histological, densitometric and biomechanical changes were evaluated. The mean radiological grade of healing and bonding to bone was higher in HA/TCP (60/40) ceramics than that of pure HA ceramics but the difference was not statistically significant. The densities of both implanted ceramics improved with time, supported by the histological evaluation of bone matrix ingrowth into ceramic pores, whereas the densities at the bone–ceramic interface decreased gradually. Flexural resonant frequencies and three-point bending strength increased, revealing an increase in mechanical stability during this early critical time interval where implant and/or bone–implant interface failures occur frequently. It can be concluded that both HA and HA/TCP (60/40) ceramics have a limited application in the treatment of load-bearing segmental bone defects but did not fail at the early stages of implantation.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>17574942</pmid><doi>10.1016/j.actbio.2007.04.004</doi><tpages>12</tpages></addata></record> |
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| identifier | ISSN: 1742-7061 |
| ispartof | Acta biomaterialia, 2007-11, Vol.3 (6), p.985-996 |
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| language | eng |
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| subjects | Animals Biocompatible Materials Biomechanics Bone defect Bone Density Bone Diseases - diagnostic imaging Bone Diseases - pathology Bone Diseases - physiopathology Bone Diseases - surgery Calcium phosphate ceramic Calcium Phosphates - chemistry Ceramics - chemistry Disease Models, Animal Durapatite - chemistry Early weight bearing Hydroxyapatite Longitudinal Studies Materials Testing Microscopy, Electron, Scanning Porosity Rabbits Radiography Time Factors Tomography Scanners, X-Ray Computed Weight-Bearing Wound Healing X-Ray Diffraction |
| title | Early weight bearing of porous HA/TCP (60/40) ceramics in vivo: A longitudinal study in a segmental bone defect model of rabbit |
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