Genetic variation in the DNA repair genes is predictive of outcome in lung cancer

To assess whether DNA repair gene variants influence the clinical behaviour of lung cancer we examined the impact of a comprehensive panel of 109 non-synonymous single-nucleotide polymorphisms (nsSNPs) in 50 DNA repair genes on overall survival (OS) in 700 lung cancer patients. Fifteen nsSNPs were a...

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Veröffentlicht in:	Human molecular genetics 2007-10, Vol.16 (19), p.2333-2340
Hauptverfasser:	Matakidou, Athena, el Galta, Rachid, Webb, Emily L., Rudd, Matthew F., Bridle, Helen, Eisen, Tim, Houlston, Richard S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphatases - genetics Biological and medical sciences DNA Helicases - genetics DNA Polymerase II - genetics DNA Polymerase theta DNA Repair - genetics DNA Repair Enzymes - genetics DNA-(Apurinic or Apyrimidinic Site) Lyase - genetics DNA-Binding Proteins - genetics DNA-Directed DNA Polymerase - genetics Endonucleases - genetics Exodeoxyribonucleases - genetics Fundamental and applied biological sciences. Psychology Genetic Variation Genetics of eukaryotes. Biological and molecular evolution Genotype Humans Kaplan-Meier Estimate Lung cancer Lung Neoplasms - genetics Lung Neoplasms - pathology Medical sciences Molecular and cellular biology Nuclear Proteins - genetics Pneumology Poly-ADP-Ribose Binding Proteins Polymorphism, Single Nucleotide Prognosis RecQ Helicases Transcription Factors - genetics Tumors of the respiratory system and mediastinum
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