Calcium, Vitamin D and the Vitamin D Receptor: Impact on Prostate and Breast Cancer in Preclinical Models
Contrary to the hypothesis, dietary calcium had no effect on urogenital morphology, tumor weight, or histological grade in LPB-Tag transgenic mice studied at 5, 7, or 9 weeks of age.7 Collectively, these three studies have demonstrated that high dietary calcium does not aggravate or accelerate prost...
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| Veröffentlicht in: | Nutrition reviews 2007-08, Vol.65 (8), p.S131-S133 |
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| creator | Mordan-McCombs, S Valrance, M Zinser, G Tenniswood, M Welsh, J.E |
| description | Contrary to the hypothesis, dietary calcium had no effect on urogenital morphology, tumor weight, or histological grade in LPB-Tag transgenic mice studied at 5, 7, or 9 weeks of age.7 Collectively, these three studies have demonstrated that high dietary calcium does not aggravate or accelerate prostate tumor growth or progression in animal models, and therefore do not support the concept that dietary calcium per se influences prostate cancer risk. Ongoing studies in this model should provide insight into the mechanism of action of synthetic vitamin D analogs that display enhanced anti-tumor actions yet reduced calcemic potency, as well as the molecular mechanisms by which the VDR mediates such a wide spectrum of biologic effects in vivo. |
| doi_str_mv | 10.1111/j.1753-4887.2007.tb00341.x |
| format | Article |
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Ongoing studies in this model should provide insight into the mechanism of action of synthetic vitamin D analogs that display enhanced anti-tumor actions yet reduced calcemic potency, as well as the molecular mechanisms by which the VDR mediates such a wide spectrum of biologic effects in vivo.</description><identifier>ISSN: 0029-6643</identifier><identifier>EISSN: 1753-4887</identifier><identifier>DOI: 10.1111/j.1753-4887.2007.tb00341.x</identifier><identifier>PMID: 17867390</identifier><identifier>CODEN: NUREA8</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Animals ; anticarcinogenic activity ; Apoptosis ; Biological and medical sciences ; Breast cancer ; breast neoplasms ; Breast Neoplasms - epidemiology ; Breast Neoplasms - etiology ; Calcium ; Calcium, Dietary - administration & dosage ; cell physiology ; Dairy products ; Diet ; dietary minerals ; epidemiological studies ; Female ; Gynecology. Andrology. Obstetrics ; Humans ; Immunization ; Male ; Mammary gland diseases ; Medical sciences ; mineral metabolism ; molecular biology ; Nephrology. Urinary tract diseases ; Nutrition ; Prostate cancer ; prostatic neoplasms ; Prostatic Neoplasms - epidemiology ; Prostatic Neoplasms - etiology ; receptors ; Receptors, Calcitriol - metabolism ; Risk Factors ; Rodents ; signal transduction ; Studies ; Tissues ; Tumors ; Tumors of the urinary system ; Urinary tract. Prostate gland ; Vitamin D ; Vitamin D - administration & dosage ; vitamin metabolism</subject><ispartof>Nutrition reviews, 2007-08, Vol.65 (8), p.S131-S133</ispartof><rights>2007 INIST-CNRS</rights><rights>Copyright International Life Sciences Institute Aug 2007</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5451-9d8726fbf09f3d35584eb3a4db8b51bed41de404886520ff4def5f7e7258c9c93</citedby><cites>FETCH-LOGICAL-c5451-9d8726fbf09f3d35584eb3a4db8b51bed41de404886520ff4def5f7e7258c9c93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1753-4887.2007.tb00341.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1753-4887.2007.tb00341.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>309,310,314,780,784,789,790,1417,23930,23931,25140,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19034324$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17867390$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mordan-McCombs, S</creatorcontrib><creatorcontrib>Valrance, M</creatorcontrib><creatorcontrib>Zinser, G</creatorcontrib><creatorcontrib>Tenniswood, M</creatorcontrib><creatorcontrib>Welsh, J.E</creatorcontrib><title>Calcium, Vitamin D and the Vitamin D Receptor: Impact on Prostate and Breast Cancer in Preclinical Models</title><title>Nutrition reviews</title><addtitle>Nutr Rev</addtitle><description>Contrary to the hypothesis, dietary calcium had no effect on urogenital morphology, tumor weight, or histological grade in LPB-Tag transgenic mice studied at 5, 7, or 9 weeks of age.7 Collectively, these three studies have demonstrated that high dietary calcium does not aggravate or accelerate prostate tumor growth or progression in animal models, and therefore do not support the concept that dietary calcium per se influences prostate cancer risk. Ongoing studies in this model should provide insight into the mechanism of action of synthetic vitamin D analogs that display enhanced anti-tumor actions yet reduced calcemic potency, as well as the molecular mechanisms by which the VDR mediates such a wide spectrum of biologic effects in vivo.</description><subject>Animals</subject><subject>anticarcinogenic activity</subject><subject>Apoptosis</subject><subject>Biological and medical sciences</subject><subject>Breast cancer</subject><subject>breast neoplasms</subject><subject>Breast Neoplasms - epidemiology</subject><subject>Breast Neoplasms - etiology</subject><subject>Calcium</subject><subject>Calcium, Dietary - administration & dosage</subject><subject>cell physiology</subject><subject>Dairy products</subject><subject>Diet</subject><subject>dietary minerals</subject><subject>epidemiological studies</subject><subject>Female</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Immunization</subject><subject>Male</subject><subject>Mammary gland diseases</subject><subject>Medical sciences</subject><subject>mineral metabolism</subject><subject>molecular biology</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Nutrition</subject><subject>Prostate cancer</subject><subject>prostatic neoplasms</subject><subject>Prostatic Neoplasms - epidemiology</subject><subject>Prostatic Neoplasms - etiology</subject><subject>receptors</subject><subject>Receptors, Calcitriol - metabolism</subject><subject>Risk Factors</subject><subject>Rodents</subject><subject>signal transduction</subject><subject>Studies</subject><subject>Tissues</subject><subject>Tumors</subject><subject>Tumors of the urinary system</subject><subject>Urinary tract. 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Ongoing studies in this model should provide insight into the mechanism of action of synthetic vitamin D analogs that display enhanced anti-tumor actions yet reduced calcemic potency, as well as the molecular mechanisms by which the VDR mediates such a wide spectrum of biologic effects in vivo.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>17867390</pmid><doi>10.1111/j.1753-4887.2007.tb00341.x</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals anticarcinogenic activity Apoptosis Biological and medical sciences Breast cancer breast neoplasms Breast Neoplasms - epidemiology Breast Neoplasms - etiology Calcium Calcium, Dietary - administration & dosage cell physiology Dairy products Diet dietary minerals epidemiological studies Female Gynecology. Andrology. Obstetrics Humans Immunization Male Mammary gland diseases Medical sciences mineral metabolism molecular biology Nephrology. Urinary tract diseases Nutrition Prostate cancer prostatic neoplasms Prostatic Neoplasms - epidemiology Prostatic Neoplasms - etiology receptors Receptors, Calcitriol - metabolism Risk Factors Rodents signal transduction Studies Tissues Tumors Tumors of the urinary system Urinary tract. Prostate gland Vitamin D Vitamin D - administration & dosage vitamin metabolism |
| title | Calcium, Vitamin D and the Vitamin D Receptor: Impact on Prostate and Breast Cancer in Preclinical Models |
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