Prevalence and Risk Factors of Diabetic Nephropathy in an Urban South Indian Population: The Chennai Urban Rural Epidemiology Study (CURES 45)
OBJECTIVE:--The aim of this study was to determine the prevalence of diabetic nephropathy among urban Asian-Indian type 2 diabetic subjects. RESEARCH DESIGN AND METHODS--Type 2 diabetic subjects (n = 1,716), inclusive of known diabetic subjects (KD subjects) (1,363 of 1,529; response rate 89.1%) and...
Gespeichert in:
| Veröffentlicht in: | Diabetes care 2007-08, Vol.30 (8), p.2019-2024 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2024 |
|---|---|
| container_issue | 8 |
| container_start_page | 2019 |
| container_title | Diabetes care |
| container_volume | 30 |
| creator | Unnikrishnan, Ranjit Rema, Mohan Pradeepa, Rajendra Deepa, Mohan Shanthirani, Coimbatore Subramaniam Deepa, Raj Mohan, Viswanathan |
| description | OBJECTIVE:--The aim of this study was to determine the prevalence of diabetic nephropathy among urban Asian-Indian type 2 diabetic subjects. RESEARCH DESIGN AND METHODS--Type 2 diabetic subjects (n = 1,716), inclusive of known diabetic subjects (KD subjects) (1,363 of 1,529; response rate 89.1%) and randomly selected newly diagnosed diabetic subjects (NDD subjects) (n = 353) were selected from the Chennai Urban Rural Epidemiology Study (CURES). Microalbuminuria was estimated by immunoturbidometric assay and diagnosed if albumin excretion was between 30 and 299 μg/mg of creatinine, and overt nephropathy was diagnosed if albumin excretion was >=300 μg/mg of creatinine in the presence of diabetic retinopathy, which was assessed by stereoscopic retinal color photography. RESULTS:--The prevalence of overt nephropathy was 2.2% (95% CI 1.51-2.91). Microalbuminuria was present in 26.9% (24.8-28.9). Compared with the NDD subjects, KD subjects had greater prevalence rates of both microalbuminuria with retinopathy and overt nephropathy (8.4 vs. 1.4%, P < 0.001; and 2.6 vs. 0.8%, P = 0.043, respectively). Logistic regression analysis showed that A1C (odds ratio 1.325 [95% CI 1.256-1.399], P < 0.001), smoking (odds ratio 1.464, P = 0.011), duration of diabetes (1.023, P = 0.046), systolic blood pressure (1.020, P < 0.001), and diastolic blood pressure (1.016, P = 0.022) were associated with microalbuminuria. A1C (1.483, P < 0.0001), duration of diabetes (1.073, P = 0.003), and systolic blood pressure (1.031, P = 0.004) were associated with overt nephropathy. CONCLUSIONS:--The results of the study suggest that in urban Asian Indians, the prevalence of overt nephropathy and microalbuminuria was 2.2 and 26.9%, respectively. Duration of diabetes, A1C, and systolic blood pressure were the common risk factors for overt nephropathy and microalbuminuria. |
| doi_str_mv | 10.2337/dc06-2554 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_68270261</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A167625315</galeid><sourcerecordid>A167625315</sourcerecordid><originalsourceid>FETCH-LOGICAL-f367t-53ade18dbbd4b4745aed4ed1616ac890c9f180775dd5282ba21a9b9c6dd02c203</originalsourceid><addsrcrecordid>eNpt0d1qFDEUAOBBFLtWL3wBDQWLXkzN7yTxrqxbLRQtu93r4UyS2U2dTcbMjLAv4TM3siuClEBOEr4TTk6K4jXBF5Qx-dEaXJVUCP6kmBHNRJmX6mkxw4TrUmhNT4oXw3CPMeZcqefFCZE5aq5nxe_b5H5B54JxCIJFSz_8QFdgxpgGFFv02UPjRm_QN9dvU-xh3O6RD9midWryvIrTuEXXwfq8uY391MHoY_iE7rYOzbcuBPBHupwSdGjRe-t2PnZxs0ercbJ79H6-Xi5WiIsPL4tnLXSDe3WMp8X6anE3_1refP9yPb-8KVtWybEUDKwjyjaN5Q2XXICz3FlSkQqM0tjoligspbBWUEUboAR0o01lLaaGYnZanB_u7VP8OblhrHd-MK7rILg4DXWlqMS0Ihme_Qfv45RCrq2mlGGmCKYZlQe0yZ2sfWjjmMBsXHD5wTG41ufjS1LJigpGRPYXj_g8_jTGPJrw5ljF1Oycrfvkd5D29d9_zODdEcBgoGsTBOOHf05pKYmS2b09uBZiDZuUzXpFMWEYS814pdkDDeeyxQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>223038102</pqid></control><display><type>article</type><title>Prevalence and Risk Factors of Diabetic Nephropathy in an Urban South Indian Population: The Chennai Urban Rural Epidemiology Study (CURES 45)</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Unnikrishnan, Ranjit ; Rema, Mohan ; Pradeepa, Rajendra ; Deepa, Mohan ; Shanthirani, Coimbatore Subramaniam ; Deepa, Raj ; Mohan, Viswanathan</creator><creatorcontrib>Unnikrishnan, Ranjit ; Rema, Mohan ; Pradeepa, Rajendra ; Deepa, Mohan ; Shanthirani, Coimbatore Subramaniam ; Deepa, Raj ; Mohan, Viswanathan</creatorcontrib><description>OBJECTIVE:--The aim of this study was to determine the prevalence of diabetic nephropathy among urban Asian-Indian type 2 diabetic subjects. RESEARCH DESIGN AND METHODS--Type 2 diabetic subjects (n = 1,716), inclusive of known diabetic subjects (KD subjects) (1,363 of 1,529; response rate 89.1%) and randomly selected newly diagnosed diabetic subjects (NDD subjects) (n = 353) were selected from the Chennai Urban Rural Epidemiology Study (CURES). Microalbuminuria was estimated by immunoturbidometric assay and diagnosed if albumin excretion was between 30 and 299 μg/mg of creatinine, and overt nephropathy was diagnosed if albumin excretion was >=300 μg/mg of creatinine in the presence of diabetic retinopathy, which was assessed by stereoscopic retinal color photography. RESULTS:--The prevalence of overt nephropathy was 2.2% (95% CI 1.51-2.91). Microalbuminuria was present in 26.9% (24.8-28.9). Compared with the NDD subjects, KD subjects had greater prevalence rates of both microalbuminuria with retinopathy and overt nephropathy (8.4 vs. 1.4%, P < 0.001; and 2.6 vs. 0.8%, P = 0.043, respectively). Logistic regression analysis showed that A1C (odds ratio 1.325 [95% CI 1.256-1.399], P < 0.001), smoking (odds ratio 1.464, P = 0.011), duration of diabetes (1.023, P = 0.046), systolic blood pressure (1.020, P < 0.001), and diastolic blood pressure (1.016, P = 0.022) were associated with microalbuminuria. A1C (1.483, P < 0.0001), duration of diabetes (1.073, P = 0.003), and systolic blood pressure (1.031, P = 0.004) were associated with overt nephropathy. CONCLUSIONS:--The results of the study suggest that in urban Asian Indians, the prevalence of overt nephropathy and microalbuminuria was 2.2 and 26.9%, respectively. Duration of diabetes, A1C, and systolic blood pressure were the common risk factors for overt nephropathy and microalbuminuria.</description><identifier>ISSN: 0149-5992</identifier><identifier>EISSN: 1935-5548</identifier><identifier>DOI: 10.2337/dc06-2554</identifier><identifier>PMID: 17488949</identifier><identifier>CODEN: DICAD2</identifier><language>eng</language><publisher>Alexandria, VA: American Diabetes Association</publisher><subject>Adult ; Aged ; Albuminuria - epidemiology ; Asians ; Associated diseases and complications ; Biological and medical sciences ; Diabetes ; Diabetes Mellitus, Type 2 - complications ; Diabetes Mellitus, Type 2 - epidemiology ; Diabetes. Impaired glucose tolerance ; Diabetic nephropathies ; Diabetic Nephropathies - epidemiology ; Diabetic retinopathy ; Diabetic Retinopathy - epidemiology ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Feeding. Feeding behavior ; Female ; Fundamental and applied biological sciences. Psychology ; Health aspects ; Humans ; Hyperglycemia ; India - epidemiology ; Male ; Medical sciences ; Middle Aged ; Patients ; Prevalence ; Regression analysis ; Research methodology ; Response rates ; Risk Factors ; Sampling techniques ; Studies ; Type 2 diabetes ; Urban areas ; Urban Population ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Vertebrates: endocrinology</subject><ispartof>Diabetes care, 2007-08, Vol.30 (8), p.2019-2024</ispartof><rights>2007 INIST-CNRS</rights><rights>COPYRIGHT 2007 American Diabetes Association</rights><rights>Copyright American Diabetes Association Aug 2007</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18977187$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17488949$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Unnikrishnan, Ranjit</creatorcontrib><creatorcontrib>Rema, Mohan</creatorcontrib><creatorcontrib>Pradeepa, Rajendra</creatorcontrib><creatorcontrib>Deepa, Mohan</creatorcontrib><creatorcontrib>Shanthirani, Coimbatore Subramaniam</creatorcontrib><creatorcontrib>Deepa, Raj</creatorcontrib><creatorcontrib>Mohan, Viswanathan</creatorcontrib><title>Prevalence and Risk Factors of Diabetic Nephropathy in an Urban South Indian Population: The Chennai Urban Rural Epidemiology Study (CURES 45)</title><title>Diabetes care</title><addtitle>Diabetes Care</addtitle><description>OBJECTIVE:--The aim of this study was to determine the prevalence of diabetic nephropathy among urban Asian-Indian type 2 diabetic subjects. RESEARCH DESIGN AND METHODS--Type 2 diabetic subjects (n = 1,716), inclusive of known diabetic subjects (KD subjects) (1,363 of 1,529; response rate 89.1%) and randomly selected newly diagnosed diabetic subjects (NDD subjects) (n = 353) were selected from the Chennai Urban Rural Epidemiology Study (CURES). Microalbuminuria was estimated by immunoturbidometric assay and diagnosed if albumin excretion was between 30 and 299 μg/mg of creatinine, and overt nephropathy was diagnosed if albumin excretion was >=300 μg/mg of creatinine in the presence of diabetic retinopathy, which was assessed by stereoscopic retinal color photography. RESULTS:--The prevalence of overt nephropathy was 2.2% (95% CI 1.51-2.91). Microalbuminuria was present in 26.9% (24.8-28.9). Compared with the NDD subjects, KD subjects had greater prevalence rates of both microalbuminuria with retinopathy and overt nephropathy (8.4 vs. 1.4%, P < 0.001; and 2.6 vs. 0.8%, P = 0.043, respectively). Logistic regression analysis showed that A1C (odds ratio 1.325 [95% CI 1.256-1.399], P < 0.001), smoking (odds ratio 1.464, P = 0.011), duration of diabetes (1.023, P = 0.046), systolic blood pressure (1.020, P < 0.001), and diastolic blood pressure (1.016, P = 0.022) were associated with microalbuminuria. A1C (1.483, P < 0.0001), duration of diabetes (1.073, P = 0.003), and systolic blood pressure (1.031, P = 0.004) were associated with overt nephropathy. CONCLUSIONS:--The results of the study suggest that in urban Asian Indians, the prevalence of overt nephropathy and microalbuminuria was 2.2 and 26.9%, respectively. Duration of diabetes, A1C, and systolic blood pressure were the common risk factors for overt nephropathy and microalbuminuria.</description><subject>Adult</subject><subject>Aged</subject><subject>Albuminuria - epidemiology</subject><subject>Asians</subject><subject>Associated diseases and complications</subject><subject>Biological and medical sciences</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Diabetes Mellitus, Type 2 - epidemiology</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Diabetic nephropathies</subject><subject>Diabetic Nephropathies - epidemiology</subject><subject>Diabetic retinopathy</subject><subject>Diabetic Retinopathy - epidemiology</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Hyperglycemia</subject><subject>India - epidemiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Patients</subject><subject>Prevalence</subject><subject>Regression analysis</subject><subject>Research methodology</subject><subject>Response rates</subject><subject>Risk Factors</subject><subject>Sampling techniques</subject><subject>Studies</subject><subject>Type 2 diabetes</subject><subject>Urban areas</subject><subject>Urban Population</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>Vertebrates: endocrinology</subject><issn>0149-5992</issn><issn>1935-5548</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpt0d1qFDEUAOBBFLtWL3wBDQWLXkzN7yTxrqxbLRQtu93r4UyS2U2dTcbMjLAv4TM3siuClEBOEr4TTk6K4jXBF5Qx-dEaXJVUCP6kmBHNRJmX6mkxw4TrUmhNT4oXw3CPMeZcqefFCZE5aq5nxe_b5H5B54JxCIJFSz_8QFdgxpgGFFv02UPjRm_QN9dvU-xh3O6RD9midWryvIrTuEXXwfq8uY391MHoY_iE7rYOzbcuBPBHupwSdGjRe-t2PnZxs0ercbJ79H6-Xi5WiIsPL4tnLXSDe3WMp8X6anE3_1refP9yPb-8KVtWybEUDKwjyjaN5Q2XXICz3FlSkQqM0tjoligspbBWUEUboAR0o01lLaaGYnZanB_u7VP8OblhrHd-MK7rILg4DXWlqMS0Ihme_Qfv45RCrq2mlGGmCKYZlQe0yZ2sfWjjmMBsXHD5wTG41ufjS1LJigpGRPYXj_g8_jTGPJrw5ljF1Oycrfvkd5D29d9_zODdEcBgoGsTBOOHf05pKYmS2b09uBZiDZuUzXpFMWEYS814pdkDDeeyxQ</recordid><startdate>20070801</startdate><enddate>20070801</enddate><creator>Unnikrishnan, Ranjit</creator><creator>Rema, Mohan</creator><creator>Pradeepa, Rajendra</creator><creator>Deepa, Mohan</creator><creator>Shanthirani, Coimbatore Subramaniam</creator><creator>Deepa, Raj</creator><creator>Mohan, Viswanathan</creator><general>American Diabetes Association</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7RV</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0K</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>M2P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope></search><sort><creationdate>20070801</creationdate><title>Prevalence and Risk Factors of Diabetic Nephropathy in an Urban South Indian Population: The Chennai Urban Rural Epidemiology Study (CURES 45)</title><author>Unnikrishnan, Ranjit ; Rema, Mohan ; Pradeepa, Rajendra ; Deepa, Mohan ; Shanthirani, Coimbatore Subramaniam ; Deepa, Raj ; Mohan, Viswanathan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-f367t-53ade18dbbd4b4745aed4ed1616ac890c9f180775dd5282ba21a9b9c6dd02c203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Albuminuria - epidemiology</topic><topic>Asians</topic><topic>Associated diseases and complications</topic><topic>Biological and medical sciences</topic><topic>Diabetes</topic><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>Diabetes Mellitus, Type 2 - epidemiology</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Diabetic nephropathies</topic><topic>Diabetic Nephropathies - epidemiology</topic><topic>Diabetic retinopathy</topic><topic>Diabetic Retinopathy - epidemiology</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Hyperglycemia</topic><topic>India - epidemiology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Patients</topic><topic>Prevalence</topic><topic>Regression analysis</topic><topic>Research methodology</topic><topic>Response rates</topic><topic>Risk Factors</topic><topic>Sampling techniques</topic><topic>Studies</topic><topic>Type 2 diabetes</topic><topic>Urban areas</topic><topic>Urban Population</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Unnikrishnan, Ranjit</creatorcontrib><creatorcontrib>Rema, Mohan</creatorcontrib><creatorcontrib>Pradeepa, Rajendra</creatorcontrib><creatorcontrib>Deepa, Mohan</creatorcontrib><creatorcontrib>Shanthirani, Coimbatore Subramaniam</creatorcontrib><creatorcontrib>Deepa, Raj</creatorcontrib><creatorcontrib>Mohan, Viswanathan</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Agricultural Science Database</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>Diabetes care</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Unnikrishnan, Ranjit</au><au>Rema, Mohan</au><au>Pradeepa, Rajendra</au><au>Deepa, Mohan</au><au>Shanthirani, Coimbatore Subramaniam</au><au>Deepa, Raj</au><au>Mohan, Viswanathan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevalence and Risk Factors of Diabetic Nephropathy in an Urban South Indian Population: The Chennai Urban Rural Epidemiology Study (CURES 45)</atitle><jtitle>Diabetes care</jtitle><addtitle>Diabetes Care</addtitle><date>2007-08-01</date><risdate>2007</risdate><volume>30</volume><issue>8</issue><spage>2019</spage><epage>2024</epage><pages>2019-2024</pages><issn>0149-5992</issn><eissn>1935-5548</eissn><coden>DICAD2</coden><abstract>OBJECTIVE:--The aim of this study was to determine the prevalence of diabetic nephropathy among urban Asian-Indian type 2 diabetic subjects. RESEARCH DESIGN AND METHODS--Type 2 diabetic subjects (n = 1,716), inclusive of known diabetic subjects (KD subjects) (1,363 of 1,529; response rate 89.1%) and randomly selected newly diagnosed diabetic subjects (NDD subjects) (n = 353) were selected from the Chennai Urban Rural Epidemiology Study (CURES). Microalbuminuria was estimated by immunoturbidometric assay and diagnosed if albumin excretion was between 30 and 299 μg/mg of creatinine, and overt nephropathy was diagnosed if albumin excretion was >=300 μg/mg of creatinine in the presence of diabetic retinopathy, which was assessed by stereoscopic retinal color photography. RESULTS:--The prevalence of overt nephropathy was 2.2% (95% CI 1.51-2.91). Microalbuminuria was present in 26.9% (24.8-28.9). Compared with the NDD subjects, KD subjects had greater prevalence rates of both microalbuminuria with retinopathy and overt nephropathy (8.4 vs. 1.4%, P < 0.001; and 2.6 vs. 0.8%, P = 0.043, respectively). Logistic regression analysis showed that A1C (odds ratio 1.325 [95% CI 1.256-1.399], P < 0.001), smoking (odds ratio 1.464, P = 0.011), duration of diabetes (1.023, P = 0.046), systolic blood pressure (1.020, P < 0.001), and diastolic blood pressure (1.016, P = 0.022) were associated with microalbuminuria. A1C (1.483, P < 0.0001), duration of diabetes (1.073, P = 0.003), and systolic blood pressure (1.031, P = 0.004) were associated with overt nephropathy. CONCLUSIONS:--The results of the study suggest that in urban Asian Indians, the prevalence of overt nephropathy and microalbuminuria was 2.2 and 26.9%, respectively. Duration of diabetes, A1C, and systolic blood pressure were the common risk factors for overt nephropathy and microalbuminuria.</abstract><cop>Alexandria, VA</cop><pub>American Diabetes Association</pub><pmid>17488949</pmid><doi>10.2337/dc06-2554</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0149-5992 |
| ispartof | Diabetes care, 2007-08, Vol.30 (8), p.2019-2024 |
| issn | 0149-5992 1935-5548 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68270261 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adult Aged Albuminuria - epidemiology Asians Associated diseases and complications Biological and medical sciences Diabetes Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - epidemiology Diabetes. Impaired glucose tolerance Diabetic nephropathies Diabetic Nephropathies - epidemiology Diabetic retinopathy Diabetic Retinopathy - epidemiology Endocrine pancreas. Apud cells (diseases) Endocrinopathies Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology Health aspects Humans Hyperglycemia India - epidemiology Male Medical sciences Middle Aged Patients Prevalence Regression analysis Research methodology Response rates Risk Factors Sampling techniques Studies Type 2 diabetes Urban areas Urban Population Vertebrates: anatomy and physiology, studies on body, several organs or systems Vertebrates: endocrinology |
| title | Prevalence and Risk Factors of Diabetic Nephropathy in an Urban South Indian Population: The Chennai Urban Rural Epidemiology Study (CURES 45) |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T18%3A30%3A29IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Prevalence%20and%20Risk%20Factors%20of%20Diabetic%20Nephropathy%20in%20an%20Urban%20South%20Indian%20Population:%20The%20Chennai%20Urban%20Rural%20Epidemiology%20Study%20(CURES%2045)&rft.jtitle=Diabetes%20care&rft.au=Unnikrishnan,%20Ranjit&rft.date=2007-08-01&rft.volume=30&rft.issue=8&rft.spage=2019&rft.epage=2024&rft.pages=2019-2024&rft.issn=0149-5992&rft.eissn=1935-5548&rft.coden=DICAD2&rft_id=info:doi/10.2337/dc06-2554&rft_dat=%3Cgale_proqu%3EA167625315%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=223038102&rft_id=info:pmid/17488949&rft_galeid=A167625315&rfr_iscdi=true |