Ocular Surface Expression and In Vitro Activity of Antimicrobial Peptides

Purpose: Human ocular surface epithelia express four antimicrobial peptides (APs): β -defensin (hBD) 1-3 and LL-37. Here the expression of additional APs (hBD 4-6, HE2β 1; histatin-1, -3; liver expressed antimicrobial peptide-1, -2; macrophage inflammatory protein (MIP)-3α, and thymosin (T)β -4) was...

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Veröffentlicht in:	Current eye research 2007-01, Vol.32 (7-8), p.595-609
Hauptverfasser:	Huang, Ling C., Jean, Daniele, Proske, Rita J., Reins, Rose Y., McDermott, Alison M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antimicrobial peptides beta-Defensins - genetics beta-Defensins - metabolism beta-Defensins - pharmacology cathelicidin Cell Culture Techniques Chemokine CCL20 Chemokines, CC - genetics Chemokines, CC - metabolism Chemokines, CC - pharmacology Colony Count, Microbial Conjunctiva - drug effects Conjunctiva - metabolism corneal epithelium Epithelial Cells - drug effects Epithelial Cells - metabolism Epithelium, Corneal - drug effects Epithelium, Corneal - metabolism Female Gene Expression - physiology Humans Interleukin-1beta - pharmacology Macrophage Inflammatory Proteins - genetics Macrophage Inflammatory Proteins - metabolism Macrophage Inflammatory Proteins - pharmacology Male Middle Aged MIP-3α/CCL20 ocular surface Pseudomonas aeruginosa Pseudomonas aeruginosa - drug effects Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism Sodium Chloride - pharmacology Staphylococcus aureus Staphylococcus aureus - drug effects Staphylococcus epidermidis - drug effects Tears - physiology Thymosin - genetics Thymosin - metabolism Thymosin - pharmacology thymosin β-4 Tumor Necrosis Factor-alpha - pharmacology β-defensins
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