Human mRNA Export Machinery Recruited to the 5′ End of mRNA

Pre-mRNAs undergo splicing to remove introns, and the spliced mRNA is exported to the cytoplasm for translation. Here we investigated the mechanism for recruitment of the conserved mRNA export machinery (TREX complex) to mRNA. We show that the human TREX complex is recruited to a region near the 5′...

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Veröffentlicht in:	Cell 2006-12, Vol.127 (7), p.1389-1400
Hauptverfasser:	Cheng, Hong, Dufu, Kobina, Lee, Chung-Sheng, Hsu, Jeanne L., Dias, Anusha, Reed, Robin
Format:	Artikel
Sprache:	eng
Schlagworte:	Exons Humans Models, Genetic Nuclear Cap-Binding Protein Complex - metabolism Nuclear Proteins - metabolism RNA Splicing RNA Transport RNA, Messenger - chemistry RNA, Messenger - genetics RNA-Binding Proteins - metabolism Spliceosomes - metabolism Transcription Factors - metabolism
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