A case of recurrent renal failure associated with metabolic alkalosis induced by protracted vomiting

We describe a case of recurrent deterioration of renal function in a 54-year-old man who was found to have metabolic alkalosis, with a maximum PaCO(2) of 73.9 mmHg and a bicarbonate concentration of 55.3 mmol/l. He had a gradual exacerbation of nausea and vomiting due to atrophic gastritis, with a s...

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Veröffentlicht in:Clinical and experimental nephrology 2006-12, Vol.10 (4), p.279-283
Hauptverfasser: Akimoto, Tetsu, Saito, Osamu, Kotoda, Atsushi, Nishino, Katsuhiko, Umino, Tetsuo, Muto, Shigeaki, Kusano, Eiji
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container_end_page 283
container_issue 4
container_start_page 279
container_title Clinical and experimental nephrology
container_volume 10
creator Akimoto, Tetsu
Saito, Osamu
Kotoda, Atsushi
Nishino, Katsuhiko
Umino, Tetsuo
Muto, Shigeaki
Kusano, Eiji
description We describe a case of recurrent deterioration of renal function in a 54-year-old man who was found to have metabolic alkalosis, with a maximum PaCO(2) of 73.9 mmHg and a bicarbonate concentration of 55.3 mmol/l. He had a gradual exacerbation of nausea and vomiting due to atrophic gastritis, with a scarred, deformed pyloric part of the stomach and a duodenal bulb secondary to chronic peptic ulcer. His metabolic alkalosis and deteriorated renal function were corrected by intravenous saline with or without potassium chloride. However, his recovered creatinine clearance was at most 60 l/day (41.6 ml/min). A renal biopsy revealed cellular infiltration of mononuclear cells and atrophic change in the tubulointerstitium, suggesting chronic interstitial nephritis. Latent renal insufficiency and dehydration induced by protracted vomiting may easily induce a rapid and recurrent deterioration of renal function, and control of vomiting seemed to be the cardinal measure. Initially, his nausea and vomiting seemed to be successfully controlled by medication, however, they later became persistent and surgical correction of the stomach was carried out. Postoperative recovery was smooth, and the patient's vomiting and recurrent deterioration of renal function finally settled.
doi_str_mv 10.1007/s10157-006-0435-6
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subjects Acid-Base Equilibrium
Alkalosis - etiology
Humans
Male
Middle Aged
Peptic Ulcer - complications
Peptic Ulcer - surgery
Recurrence
Renal Insufficiency - etiology
Stomach - surgery
Vomiting - complications
title A case of recurrent renal failure associated with metabolic alkalosis induced by protracted vomiting
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