Modulation of cyclic nucleotide-regulated HCN channels by PIP(2) and receptors coupled to phospholipase C

Recent results indicate that phosphoinositides, including phosphatidylinositol 4,5-bisphosphate (PI(4,5)P(2)), directly enhance the opening of hyperpolarization-activated, cyclic nucleotide-regulated (HCN) channels by shifting their activation gating to more positive voltages. This contrasts with th...

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Veröffentlicht in:	Pflügers Archiv 2007-10, Vol.455 (1), p.125-145
Hauptverfasser:	Pian, Phillip, Bucchi, Annalisa, Decostanzo, Anthony, Robinson, Richard B, Siegelbaum, Steven A
Format:	Artikel
Sprache:	eng
Schlagworte:	Androstadienes - pharmacology Animals Chromones - pharmacology Cyclic AMP - physiology Cyclic Nucleotide-Gated Cation Channels - drug effects Data Interpretation, Statistical Electrophysiology Enzyme Inhibitors - pharmacology Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels In Vitro Techniques Indicators and Reagents Ion Channel Gating - drug effects Ion Channel Gating - physiology Membrane Potentials - drug effects Morpholines - pharmacology Oocytes - metabolism Patch-Clamp Techniques Phosphatidylinositol 4,5-Diphosphate - pharmacology Potassium Channels - drug effects Rabbits Receptor, Bradykinin B2 - drug effects Type C Phospholipases - metabolism Wortmannin Xenopus
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