Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis

Blood line VEGF, or vascular endothelial growth factor, is the best-characterized inducer of tumour angiogenesis, and the blockade of VEGF has become an important tool in cancer therapy. But VEGF blockade is not effective against all tumours, so the search for alternative approaches continues. Two g...

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Veröffentlicht in:	Nature 2006-12, Vol.444 (7122), p.1083-1087
Hauptverfasser:	Ridgway, John, Zhang, Gu, Wu, Yan, Stawicki, Scott, Liang, Wei-Ching, Chanthery, Yvan, Kowalski, Joe, Watts, Ryan J., Callahan, Christopher, Kasman, Ian, Singh, Mallika, Chien, May, Tan, Christine, Hongo, Jo-Anne S., de Sauvage, Fred, Plowman, Greg, Yan, Minhong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomedical research Cell Differentiation Cell Line Cell Proliferation Cellular biology Endothelium, Vascular - cytology Homeostasis Humanities and Social Sciences Humans Intestine, Small - cytology Intestine, Small - metabolism Intracellular Signaling Peptides and Proteins letter Membrane Proteins - antagonists & inhibitors Membrane Proteins - metabolism Mice multidisciplinary Neoplasms - blood supply Neoplasms - pathology Neovascularization, Pathologic Receptors, Notch - metabolism Science Science (multidisciplinary) Signal Transduction Tumors Vascular Endothelial Growth Factor A - antagonists & inhibitors Vascular Endothelial Growth Factor A - metabolism Veins & arteries
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