Amyloid Protofibril is Highly Voluminous and Compressible

We report here results of the first direct measurement of partial volume and compressibility changes of a protein as it forms an amyloid protofibril. We use a high precision density meter and an ultrasonic velocity meter on a solution of intrinsically denatured, disulfide-deficient variant of hen ly...

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Veröffentlicht in:	Biochemistry (Easton) 2007-09, Vol.46 (37), p.10444-10450
Hauptverfasser:	Akasaka, Kazuyuki, Latif, Abdul Raziq Abdul, Nakamura, Akihiro, Matsuo, Koichi, Tachibana, Hideki, Gekko, Kunihiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyloid - chemistry Animals Biomechanical Phenomena Circular Dichroism Kinetics Muramidase - chemistry Time Factors Ultrasonics
Online-Zugang:	Volltext
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