Dendrimer-encapsulated camptothecins : Increased solubility, cellular uptake, and cellular retention affords enhanced anticancer activity in vitro
A biocompatible polyester dendrimer composed of the natural metabolites, glycerol and succinic acid, is described for the encapsulation of the antitumor camptothecins, 10-hydroxycamptothecin and 7-butyl-10-aminocamptothecin. The cytotoxicity of the dendrimer-drug complex toward four different human...
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| Veröffentlicht in: | Cancer research (Chicago, Ill.) Ill.), 2006-12, Vol.66 (24), p.11913-11921 |
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| container_title | Cancer research (Chicago, Ill.) |
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| creator | MORGAN, Meredith T NAKANISHI, Yuka KROLL, David J GRISET, Aaron P CARNAHAN, Michael A WATHIER, Michel OBERLIES, Nicholas H MANIKUMAR, Govindarajan WANI, Mansukh C GRINSTAFF, Mark W |
| description | A biocompatible polyester dendrimer composed of the natural metabolites, glycerol and succinic acid, is described for the encapsulation of the antitumor camptothecins, 10-hydroxycamptothecin and 7-butyl-10-aminocamptothecin. The cytotoxicity of the dendrimer-drug complex toward four different human cancer cell lines [human breast adenocarcinoma (MCF-7), colorectal adenocarcinoma (HT-29), non-small cell lung carcinoma (NCI-H460), and glioblastoma (SF-268)] is also reported, and low nmol/L IC(50) values are measured. Cellular uptake and efflux measurements in MCF-7 cells show an increase of 16-fold for cellular uptake and an increase in drug retention within the cell when using the dendrimer vehicle. |
| doi_str_mv | 10.1158/0008-5472.can-06-2066 |
| format | Article |
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Drug treatments ; Solubility ; Tumors</subject><ispartof>Cancer research (Chicago, Ill.), 2006-12, Vol.66 (24), p.11913-11921</ispartof><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c469t-8aebf5cad2785a8fefac6a4a7f529ff9634c2d1496a9e515e6f81a45e4d889fe3</citedby><cites>FETCH-LOGICAL-c469t-8aebf5cad2785a8fefac6a4a7f529ff9634c2d1496a9e515e6f81a45e4d889fe3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3343,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18378405$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17178889$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MORGAN, Meredith T</creatorcontrib><creatorcontrib>NAKANISHI, Yuka</creatorcontrib><creatorcontrib>KROLL, David J</creatorcontrib><creatorcontrib>GRISET, Aaron P</creatorcontrib><creatorcontrib>CARNAHAN, Michael A</creatorcontrib><creatorcontrib>WATHIER, Michel</creatorcontrib><creatorcontrib>OBERLIES, Nicholas H</creatorcontrib><creatorcontrib>MANIKUMAR, Govindarajan</creatorcontrib><creatorcontrib>WANI, Mansukh C</creatorcontrib><creatorcontrib>GRINSTAFF, Mark W</creatorcontrib><title>Dendrimer-encapsulated camptothecins : Increased solubility, cellular uptake, and cellular retention affords enhanced anticancer activity in vitro</title><title>Cancer research (Chicago, Ill.)</title><addtitle>Cancer Res</addtitle><description>A biocompatible polyester dendrimer composed of the natural metabolites, glycerol and succinic acid, is described for the encapsulation of the antitumor camptothecins, 10-hydroxycamptothecin and 7-butyl-10-aminocamptothecin. The cytotoxicity of the dendrimer-drug complex toward four different human cancer cell lines [human breast adenocarcinoma (MCF-7), colorectal adenocarcinoma (HT-29), non-small cell lung carcinoma (NCI-H460), and glioblastoma (SF-268)] is also reported, and low nmol/L IC(50) values are measured. 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Drug treatments</subject><subject>Solubility</subject><subject>Tumors</subject><issn>0008-5472</issn><issn>1538-7445</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcFOHSEUhknTpl5tH0HDpl05CjPAMO7Mba0mpm7aNTmXOUR0LjMC08TX8Ill4k3v0tWBw_f_wPkJOebsjHOpzxljupKirc8shIqpqmZKfSArLhtdtULIj2T1nzkghyk9lK3kTH4mB7zlrda6W5GXHxj66LcYKwwWpjQPkLGnFrZTHvM9Wh8SvaA3wUaEVE7SOMwbP_j8fEotDkMRRDpPGR7xlELo982IGUP2Y6Dg3Bj7RDHcQ7DFBErfLstIwWb_r7hRH2ipcfxCPjkYEn7d1SPy9-rnn_V1dXv362Z9eVtZobpcacCNkxb6utUStEMHVoGA1sm6c65TjbB1z0WnoEPJJSqnOQiJoi8_d9gcke9vvlMcn2ZM2Wx9Wh4PAcc5GaVr2XKh3wV5J1nd6K6A8g20cUwpojNTGS3EZ8OZWVIzSyJmScSsL38bpsySWtGd7C6YN1vs96pdTAX4tgMgWRhcLKPzac_pptWCyeYV7BOk6w</recordid><startdate>20061215</startdate><enddate>20061215</enddate><creator>MORGAN, Meredith T</creator><creator>NAKANISHI, Yuka</creator><creator>KROLL, David J</creator><creator>GRISET, Aaron P</creator><creator>CARNAHAN, Michael A</creator><creator>WATHIER, Michel</creator><creator>OBERLIES, Nicholas H</creator><creator>MANIKUMAR, Govindarajan</creator><creator>WANI, Mansukh C</creator><creator>GRINSTAFF, Mark W</creator><general>American Association for Cancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20061215</creationdate><title>Dendrimer-encapsulated camptothecins : Increased solubility, cellular uptake, and cellular retention affords enhanced anticancer activity in vitro</title><author>MORGAN, Meredith T ; NAKANISHI, Yuka ; KROLL, David J ; GRISET, Aaron P ; CARNAHAN, Michael A ; WATHIER, Michel ; OBERLIES, Nicholas H ; MANIKUMAR, Govindarajan ; WANI, Mansukh C ; GRINSTAFF, Mark W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c469t-8aebf5cad2785a8fefac6a4a7f529ff9634c2d1496a9e515e6f81a45e4d889fe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Antineoplastic agents</topic><topic>Antineoplastic Agents, Phytogenic - pharmacokinetics</topic><topic>Antineoplastic Agents, Phytogenic - therapeutic use</topic><topic>Biocompatible Materials</topic><topic>Biological and medical sciences</topic><topic>Biological Transport</topic><topic>Brain Neoplasms</topic><topic>Breast Neoplasms</topic><topic>Camptothecin - pharmacokinetics</topic><topic>Camptothecin - therapeutic use</topic><topic>Capsules</topic><topic>Carcinoma, Non-Small-Cell Lung</topic><topic>Cell Line, Tumor</topic><topic>Colorectal Neoplasms</topic><topic>Dendrimers - pharmacokinetics</topic><topic>Dendrimers - therapeutic use</topic><topic>Female</topic><topic>Glioblastoma</topic><topic>Humans</topic><topic>Lung Neoplasms</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Medical sciences</topic><topic>Pharmacology. 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| ispartof | Cancer research (Chicago, Ill.), 2006-12, Vol.66 (24), p.11913-11921 |
| issn | 0008-5472 1538-7445 |
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| source | MEDLINE; American Association for Cancer Research; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Antineoplastic agents Antineoplastic Agents, Phytogenic - pharmacokinetics Antineoplastic Agents, Phytogenic - therapeutic use Biocompatible Materials Biological and medical sciences Biological Transport Brain Neoplasms Breast Neoplasms Camptothecin - pharmacokinetics Camptothecin - therapeutic use Capsules Carcinoma, Non-Small-Cell Lung Cell Line, Tumor Colorectal Neoplasms Dendrimers - pharmacokinetics Dendrimers - therapeutic use Female Glioblastoma Humans Lung Neoplasms Magnetic Resonance Spectroscopy Medical sciences Pharmacology. Drug treatments Solubility Tumors |
| title | Dendrimer-encapsulated camptothecins : Increased solubility, cellular uptake, and cellular retention affords enhanced anticancer activity in vitro |
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