Intrinsic Fluorescence Reports a Global Conformational Change in the N-Lobe of Human Serum Transferrin following Iron Release

Transferrins have been extensively studied in order to understand how they reversibly bind and release iron. Human serum transferrin (hTF) is a single polypeptide chain that folds into two lobes (N- and C-lobe); each lobe binds a single ferric ion. Iron release induces a large conformational change...

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Veröffentlicht in:	Biochemistry (Easton) 2007-09, Vol.46 (37), p.10603-10611
Hauptverfasser:	James, Nicholas G, Berger, Christopher L, Byrne, Shaina L, Smith, Valerie C, MacGillivray, Ross T. A, Mason, Anne B
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorption Crystallography, X-Ray Cystine - metabolism Humans Hydrogen-Ion Concentration Iron - metabolism Kinetics Mutant Proteins - chemistry Oxidation-Reduction Protein Structure, Secondary Spectrometry, Fluorescence Structure-Activity Relationship Transferrin - chemistry Transferrin - metabolism Tryptophan
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