Calmodulin-androgen receptor (AR) interaction : Calcium-dependent, calpain-mediated breakdown of AR in LNCaP prostate cancer cells

Chemotherapy of prostate cancer targets androgen receptor (AR) by androgen ablation or antiandrogens, but unfortunately, it is not curative. Our attack on prostate cancer envisions the proteolytic elimination of AR, which requires a fuller understanding of AR turnover. We showed previously that calm...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2006-12, Vol.66 (24), p.11754-11762
Hauptverfasser:	PELLEY, Ronald P, CHINNAKANNU, Kannagi, MURTHY, Shalini, STRICKLAND, Faith M, MENON, Mani, PING DOU, Q, BARRACK, Evelyn R, REDDY, G. Prem-Veer
Format:	Artikel
Sprache:	eng
Schlagworte:	Androgen Antagonists - therapeutic use Antineoplastic agents Biological and medical sciences Calcimycin - pharmacology Calcium - physiology Calmodulin - isolation & purification Calmodulin - physiology Calpain - metabolism Cell Line, Tumor Cell Nucleus - physiology Chelating Agents - pharmacology Chromatography, Affinity Cytoplasm - physiology Gynecology. Andrology. Obstetrics Humans Ionophores - pharmacology Isoleucine - deficiency Male Male genital diseases Medical sciences Nephrology. Urinary tract diseases Pharmacology. Drug treatments Prostatic Neoplasms - drug therapy Prostatic Neoplasms - pathology Prostatic Neoplasms - physiopathology Receptors, Androgen - physiology Receptors, Androgen - radiation effects Signal Transduction Tumors Tumors of the urinary system Ultraviolet Rays Urinary tract. Prostate gland
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