Cyclophilin A Protects Peg3 from Hypermethylation and Inactive Histone Modification

Imprinted genes are expressed from only one of the parental alleles and are marked epigenetically by DNA methylation and histone modifications. Disruption of normal imprinting leads to abnormal embryogenesis, certain inherited diseases, and is associated with various cancers. In the context of scree...

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Veröffentlicht in:	The Journal of biological chemistry 2006-12, Vol.281 (51), p.39081-39087
Hauptverfasser:	Lu, Ying-Chun, Song, Jun, Cho, Hee-Yeon, Fan, Guoping, Yokoyama, Kazunari K., Chiu, Robert
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Animals Chromatin Immunoprecipitation CpG Islands Cyclophilin A - chemistry DNA Methylation DNA, Complementary - metabolism Epigenesis, Genetic Gene Silencing Genomic Imprinting Histones - chemistry Humans Kruppel-Like Transcription Factors Lysine - chemistry Mice Protein Kinases - genetics Protein Kinases - physiology Transcription Factors - genetics Transcription Factors - physiology
Online-Zugang:	Volltext
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