Phosphorylation of MCM4 by Cdc7 Kinase Facilitates Its Interaction with Cdc45 on the Chromatin

Cdc7 kinase, conserved from yeasts to human, plays important roles in DNA replication. However, the mechanisms by which it stimulates initiation of DNA replication remain largely unclear. We have analyzed phosphorylation of MCM subunits during cell cycle by examining mobility shift on SDS-PAGE. MCM4...

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Veröffentlicht in:	The Journal of biological chemistry 2006-12, Vol.281 (51), p.39249-39261
Hauptverfasser:	Masai, Hisao, Taniyama, Chika, Ogino, Keiko, Matsui, Etsuko, Kakusho, Naoko, Matsumoto, Seiji, Kim, Jung-Min, Ishii, Ai, Tanaka, Taku, Kobayashi, Toshiko, Tamai, Katsuyuki, Ohtani, Kiyoshi, Arai, Ken-ichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Cell Cycle Proteins - chemistry Cell Cycle Proteins - physiology Chromatin - chemistry DNA Helicases - chemistry DNA Helicases - physiology DNA-Binding Proteins - chemistry DNA-Binding Proteins - physiology Humans Mice Minichromosome Maintenance Complex Component 4 Molecular Sequence Data Nuclear Proteins - chemistry Nuclear Proteins - physiology Phosphorylation Protein Structure, Tertiary Protein-Serine-Threonine Kinases - chemistry Protein-Serine-Threonine Kinases - physiology Sequence Homology, Amino Acid
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